COMBINED PHOTODYNAMIC AND PULSED DYE LASER TREATMENT OF PORT WINE STAINS

光动力和脉冲染料激光相结合处理波特酒污渍

• 批准号: 7725011
• 负责人: KRISTEN M KELLY
• 金额: $ 0.09万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7725011
• 关键词: Appearance; Blood Vessels; Caliber; Caring; Chemicals; Cicatrix; Clinical; Computer Retrieval of Information on Scientific Projects Database; Depth; Dyes; Funding; Grant; Institution; Lasers; Lesion; Light; Methods; Patients; Photochemotherapy; Photosensitivity; Photosensitizing Agents; Physiologic pulse; Port-Wine Stain; Pulse taking; Reactive Oxygen Species; Research; Research Personnel; Resources; Singlet Oxygen; Skin; Source; Standards of Weights and Measures; Tissues; United States; United States National Institutes of Health; day; experience; malformation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Port wine stains (PWS) are congenital vascular malformations of the skin present in 1.5 million patients in the United States. The pulsed dye laser (PDL) is the standard of care for treatment of these lesions and by selectively targeting tissue vasculature, lightens these lesions in some PWS patients. However, few patients (< 10%) achieve complete blanching of their lesion and multiple treatments (5 -30 or more) are generally required (1). One primary factor limiting PWS lesion blanching for many patients is the limited ability of the PDL to remove small (less than 20 m diameter) superficial vessels, which contribute significantly to the clinical appearance of these birthmarks (2). Another highly effective method for selectively targeting tissue vasculature is photodynamic therapy (PDT), which utilizes a chemical photosensitizer and light to generate singlet oxygen radicals (3). PDT using red light and vascular specific photosensitizers has been implemented in a few small trials for PWS treatment (4,5,6). Impressive lesion lightening was noted; however, mild scarring also occurred in some cases as a result of total and deep vascular destruction induced by the use of long wavelength red light. Further, patients experienced prolonged photosensitivity (30 days).

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 港口葡萄酒污渍（PWS）是美国150万患者的皮肤的先天性血管畸形。 脉冲染料激光器（PDL）是治疗这些病变的护理标准，通过选择性靶向组织脉管系统，在某些PWS患者中减轻了这些病变。 但是，很少有患者（<10％）获得病变的完全毛病，通常需要多种治疗（5-30或更多）（1）。 对于许多患者来说，限制PWS病变的一个主要因素是PDL去除小（小于20 m）浅表血管的能力有限，这对这些胎记的临床表现产生了显着贡献（2）。 选择性靶向组织脉管系统的另一种高效方法是光动力疗法（PDT），它利用化学光敏剂和光产生单重氧自由基（3）。 使用红光和血管特异性光敏剂的PDT已在一些小型PWS治疗中实施（4,5,6）。 注意到了令人印象深刻的病变照明。然而，在某些情况下，由于使用长波长红光引起的全部和深血管破坏而导致轻度疤痕。 此外，患者经历了长时间的光敏性（30天）。