A PILOT STUDY OF SALSALATE IN REDUCING SYSTEMIC INFLAMMATION AND IMPROVING EN

水杨酸减少全身炎症和改善 EN 的试点研究

• 批准号: 7717570
• 负责人: SAMIR KUMAR GUPTA
• 金额: $ 0.93万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717570
• 关键词: Academic Medical Centers; Anti-Inflammatory Agents; Anti-inflammatory; C-reactive protein; CD4 Lymphocyte Count; Cardiovascular system; Computer Retrieval of Information on Scientific Projects Database; Enrollment; Functional disorder; Funding; Grant; Immunologics; Indiana; Individual; Inflammation; Institution; Label; Measures; Mediating; Patients; Pharmaceutical Preparations; Pilot Projects; Research; Research Personnel; Resources; Safety; Source; United States National Institutes of Health; Upper arm; Week; antiretroviral therapy; improved; prospective; salicylsalicylic acid

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a prospective, single center, single arm, open-label, pilot study evaluating the potential efficacy and safety of salsalate (SSA), a non-steroidal anti-inflammatory drug (NSAID), in the treatment of endothelial dysfunction in twelve HIV-infected patients seen at the Indiana University Medical Center with high sensitivity C-reactive protein (hsCRP) levels greater than or equal to 2.5mg/L, with CD4 cell counts greater than 350/¿L, and not currently receiving antiretroviral therapy. Enrolled subjects will have their brachial flow-mediated dilation (FMD), a measure of endothelial function, and other cardiovascular and immunologic parameters measured at baseline and again after 4 and 8 weeks of treatment with SSA. Each individual subject will be followed for approximately 10 weeks. The total duration of this study will be approximately 8 months.

该副本是使用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这是调查员的机构。 This is a prospective, single center, single arm, open-label, pilot study evaluating the potential effectiveness and safety of salasalate (SSA), a non-steroidal anti-inflammatory drug (NSAID), in the treatment of endothelial dysfunction in twelve HIV-infected patients see at the Indiana University Medical Center with high sensitivity C-reactive protein (hsCRP) levels greater than or equal to 2.5mg/L，CD4细胞计数大于350/»，目前尚未接受抗逆转录病毒疗法。注册的受试者将具有臂流介导的词典（FMD），对内皮功能的测量以及其他在基线和SSA治疗4和8周后测量的心血管和免疫学参数。每个受试者将遵循大约10周。这项研究的总持续时间约为8个月。