HIV-RELATED PROTEINURIA AND ENDOTHELIAL DYSFUNCTION

HIV 相关蛋白尿和内皮功能障碍

• 批准号: 7606412
• 负责人: SAMIR KUMAR GUPTA
• 金额: $ 1.14万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606412
• 关键词: Adult; Aspirin; Blood Tests; Body Image; Cholesterol; Computer Retrieval of Information on Scientific Projects Database; Diabetes Mellitus; Enrollment; Exercise; Functional disorder; Funding; Grant; High Blood Pressure; Individual; Institution; Measurement; Mediating; Observational Study; Participant; Pharmaceutical Preparations; Procedures; Proteinuria; Questionnaires; Research; Research Personnel; Resources; Source; Ultrasonography; United States National Institutes of Health; Urine; brachial artery; cardiovascular risk factor; day; prospective

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This prospective observational study will evaluate the associations between proteinuria and existing and progressive endothelial dysfunction in adult, HIV-infected individuals. Subjects with and without proteinuria will have their brachial-flow mediated dilation and other cardiovascular risk factors compared at baseline and again 24 months later. A total of 72 subjects, 36 subjects with persistent proteinuria and 36 non-proteinuric subjects, are expected to enroll in the study and be followed for approximately thirty months. Study procedures will include vital sign measurements, anthropometrics, urine and blood tests, and brachial artery ultrasound measurements. Subjects will be asked to complete questionnaires about their exercise activities and body image. Participants will be asked to stop taking any aspirin or aspirin like medications, diabetes medications, high blood pressure medications, and high cholesterol medications for five days before each of the ultrasound measurements.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项前瞻性观察性研究将评估蛋白尿与成人感染HIV的个体中现有和进行性内皮功能障碍的关联。 在基线和24个月后，患有和没有蛋白尿的受试者将具有臂流介导的扩张和其他心血管危险因素。 总共有72名受试者，36名患有持续性蛋白尿的受试者和36名非蛋白尿受试者将参与研究，并遵循大约30个月。 研究程序将包括生命体征测量，拟人化，尿液和血液检查以及臂动脉超声测量。 将要求受试者填写有关其运动活动和身体形象的问卷。 将要求参与者停止服用任何阿司匹林或阿司匹林，例如药物，糖尿病药物，高血压药物和高胆固醇药物，直到每种超声测量。