Exploring otoacoustic emissions with intracochlear pressure and motion measuremen

通过耳蜗内压力和运动测量探索耳声发射

• 批准号: 8607842
• 负责人: Wei Dong
• 金额: $ 20.7万
• 依托单位: LOMA LINDA VETERANS ASSN RESEARCH & EDUC
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-01 至 2017-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8607842
• 关键词: Amplifiers; Auditory; Back; Basilar Membrane; Cells; Characteristics; Clinic; Cochlea; Diagnostic; External auditory canal; Foundations; Frequencies; Generations; Gerbils; Goals; Hearing; Human; Image; Impairment; Laboratories; Lasers; Lead; Light; Link; Liquid substance; Maps; Measurement; Measures; Mechanics; Modeling; Motion; Outer Hair Cells; Physiology; Principal Investigator; Process; Research; Rest; Rodent; Role; Scala Tympani; Sensory; Shapes; Signal Transduction; Site; Source; Stapes; Techniques; Testing; Travel; Work; base; clinical application; design; hearing screening; in vivo; middle ear; operation; otoacoustic emission; pressure; programs; research study; response; sensor; signal processing; sound; theories; tool; transmission process

DESCRIPTION (provided by applicant): The experiments proposed in the current application use well-established micro-pressure-sensor and laser Doppler vibrometer techniques to probe underlying cochlear mechanics relating to otoacoustic emissions (OAEs). This application aims to provide direct intracochlear observation in vivo to further understand the fundamental questions in OAE generation, propagation and cochlear signal processing in reverse transmission. The first aim will explore the cochlear active process in reverse transmission and the rest of the aims will continue and extend our previous work on the generation and propagation of distortion product OAEs (DPOAEs) in the cochlea. OAEs are sounds generated within the cochlea and being detected in the ear canal, carrying the information about the mechanisms that generate and shape them, thus providing a noninvasive view into cochlear mechanics. However, how to relate OAE to cochlea mechanics is a big challenge in OAE research. In the forward direction, sound causes a traveling wave along the cochlear partition, which is boosted by the outer hair cells' activity (cochlear amplifier). However, the role of cochlear amplifier and cochlear fluid in cochlear reverse transmission is not clear. With simultaneous intracochlear (the basilar membrane velocity and intracochlear pressure) and ear canal pressure measurements, aim one studies the generation sites of OAE in the cochlea and further explore multiple tones suppression in active cochleae; aim two is designed to quantify the traveling wave and compression wave pressures in both forward and reverse transmissions; aim three explores the cochlear active process in reverse transmission. Thus the results will provide fundamental intracochlear observations, test the OAE generation theories and form the foundation for developing three-dimensional cochlear model. Finally, results from the current application will lead to more efficient OAE hearing screening program used in research and clinic.

描述（由申请人提供）：当前申请中提出的实验使用成熟的微压力传感器和激光多普勒振动计技术来探测与耳声发射（OAE）相关的潜在耳蜗力学。该应用旨在提供直接的体内耳蜗内观察，以进一步了解反向传输中 OAE 产生、传播和耳蜗信号处理的基本问题。第一个目标将探索反向传输中的耳蜗主动过程，其余目标将继续并扩展我们之前关于耳蜗中畸变产物 OAE (DPOAE) 的生成和传播的工作。 OAE 是耳蜗内产生并在耳道中检测到的声音，携带有关产生和塑造它们的机制的信息，从而提供耳蜗力学的非侵入性视图。然而，如何将OAE与耳蜗力学联系起来是OAE研究的一大挑战。在向前的方向上，声音沿着耳蜗分区产生行波，该行波由外毛细胞的活动（耳蜗放大器）增强。然而，耳蜗放大器和耳蜗液在耳蜗反向传递中的作用尚不清楚。通过同时进行耳蜗内（基底膜速度和耳蜗内压力）和耳道压力测量，目的一是研究耳蜗中 OAE 的产生部位，并进一步探索活跃耳蜗中的多音抑制；目标二旨在量化正向和反向传输中的行波和压缩波压力；目标三探讨逆向传输中的耳蜗主动过程。因此，研究结果将提供基本的耳蜗内观察结果，检验 OAE 生成理论，并为开发三维耳蜗模型奠定基础。最后，当前应用的结果将导致在研究和临床中使用更有效的 OAE 听力筛查程序。