EFFECT OF STATIN THERAPY ON WHOLE BODY ENERGY HOMEOSTASIS

他汀类药物治疗对全身能量稳态的影响

• 批准号: 7719468
• 负责人: WILLIAM Read HIATT
• 金额: $ 0.23万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719468
• 关键词: Class; Computer Retrieval of Information on Scientific Projects Database; Fatty Acids; Funding; Glucose; Grant; Homeostasis; Institution; Peripheral arterial disease; Pharmaceutical Preparations; Pilot Projects; Reporting; Research; Research Personnel; Resources; Source; Syndrome; Toxic effect; United States National Institutes of Health; base; design; diabetic; man

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The proposed study will definitively define the effect of statin treatment on whole body fuel homeostasis. Any changes identified will have immediate importance in understanding statin effects in man. More mechanistic studies can be immediately designed and implemented based on the results of this pilot study. Definition of the effects of statins on energy homeostasis has direct implications for understanding both the efficacy and putative toxicity of this important class of drugs. An effect of statins to shift fuel utilization from fatty acids to glucose might also be relevant to statin therapy in diabetics and reports of functional benefits of statins in ischemic syndromes, such as peripheral arterial disease, where glucose would represent a more efficient energy substrate.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 拟议的研究将确定定义他汀类药物治疗对全身燃料稳态的影响。 确定的任何变化将立即在理解人汀类药物的影响方面具有重要意义。 可以根据该试点研究的结果立即设计和实施更多的机械研究。 他汀类药物对能量稳态的影响的定义对理解这一重要类药物的疗效和推定毒性具有直接的影响。 他汀类药物将燃料利用率从脂肪酸转移到葡萄糖的作用也可能与糖尿病患者的他汀类药物治疗有关，并报道了他汀类药物在缺血性综合症（例如外周动脉疾病）中的功能益处，其中葡萄糖将代表更有效的能量底物。