NONINSULIN DEPENDENT DIABETES MELLITUS EFFECT ON RESPIRATORY EXCHANGE RATIO

非胰岛素依赖性糖尿病对呼吸交换比的影响

• 批准号: 6275344
• 负责人: WILLIAM Read HIATT
• 金额: $ 3.14万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6275344
• 关键词: clinical research; exercise; female; human subject; noninsulin dependent diabetes mellitus; oxygen consumption; respiratory oxygenation; women's health

Exercise performance is impaired both at maximal and sumaximal levels in persons with niddm, especially women, even in the absence of complications. One finding in particular was that vo2/work load was lower in niddm compared to control during exercise, a finding which in certain cardiorespiratory disease states has been interpreted to suggest impaired oxygen delivery. In addition, we found that the respiratory exchange radio was higher in niddm than in nondiabetics for submaximal work loads. We propose to extend our studies of the vo2/work load relationship in niddm by measuring vo2 kinetics and heart rate kinetics (descriptors of cardiopulmonary responses to exercise) and respiratory exchange ratio during bouts of constant load exercise on the bicycle ergometer. In addition, we will evaluate the effects of three months of exercise training on these parameters. Patients will include 10 premenopausal women with uncomplicated niddm. 10 Weight and age matched nondiabetic women and 10 lean age matched nondiabetic women (to control for effects of obesity). Slowed vo2 kinetics with slowed heart rate kinetics would suggest an impairment in oxygen delivery in niddm. The importance of these studies is 1. To use measurements of the rate of rise in oxygen consumption and heart rate with exercise (oxygen uptake kinetics) to determine whether there is a difference between persons with niddm and controls in terms of the adequacy with which oxygen is supplied to exercise cardiovascular function during exercise both at baseline and after modification by exercise training.

运动表现在最大和umaximal水平上受到损害 即使在没有NIDDM的人，尤其是女性的人 并发症。 特别是发现VO2/工作负载较低 在NIDDM中与锻炼过程中的对照相比，这一发现在某些发现 心肺疾病状态已被解释为表明受损 氧递送。此外，我们发现呼吸交换无线电 对于次最大工作负荷，NIDDM的NIDDM高于非糖尿病。我们 建议扩展我们对NIDDM中VO2/工作负荷关系的研究 通过测量VO2动力学和心率动力学（描述符 对运动的心肺反应）和呼吸道交换比率 在自行车测量计的恒定负载练习期间。 在 此外，我们将评估三个月运动的影响 对这些参数进行培训。 患者将包括10个绝经前 NIDDM简单的妇女。 10重量和年龄匹配的非糖尿病 妇女和10个瘦年与非糖尿病妇女相匹配（控制 肥胖）。 心率动力学减慢的VO2动力学减慢了 建议在NIDDM中的氧递送受损。这些的重要性 研究是1。使用氧气升高速率的测量值 运动（氧气吸收动力学）的消费和心率 确定NIDDM和 从提供氧气的充分性方面的控制 在基线和运动期间运动期间的心血管功能 通过运动训练进行修改。