NONINSULIN DEPENDENT DIABETES MELLITUS EFFECT ON RESPIRATORY EXCHANGE RATIO

非胰岛素依赖性糖尿病对呼吸交换比的影响

• 批准号: 6114109
• 负责人: WILLIAM Read HIATT
• 金额: $ 3.22万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6114109
• 关键词: clinical research; exercise; female; human subject; noninsulin dependent diabetes mellitus; oxygen consumption; respiratory oxygenation; women's health

Exercise performance is impaired both at maximal and submaximal levels in persons with NIDDM, especially women, even in the absence of complications. One finding in particular was that VO2/work load was lower in NIDDM compared to control during exercise, a finding which in certain cardiorespiratory disease states has been interpreted to suggest impaired oxygen delivery. We propose to extend our studies of the VO2/work load relationship in NIDDM by measuring VO2 kinetics and heart rate kinetics (descriptors of cardiopulmonary responses to exercise) during bouts of constant load exercise on the bicycle ergometer. In addition, we will evaluate the effects of three months of exercise training on these parameters. Patients will include 10 premenopausal women with uncomplicated NIDDM, 10 weight and age matched nondiabetic women and 10 lean age matched nondiabetic women (to control for effects of obesity). Slowed VO2 kinetics with slowed heart rate kinetics would suggest an impairment in oxygen delivery in NIDDM. The importance of these studies is 1) to use measurements of the rate of rise in oxygen consumption and heart rate with exercise(oxygen uptake kinetics) to determine whether there is a difference between persons with NIDDM and controls in terms of the adequacy with which oxygen is supplied to exercising muscle, and 2) to further understand the effects of NIDDM on cardiovascular function during exercise both at baseline and after modification by exercise training.

在没有并发症的情况下，即使在没有并发症的情况下，运动表现在最大和次最大的水平上都受到损害。特别是发现，NIDDM中的VO2/工作负荷与运动过程中的对照相比，这一发现在某些心脏呼吸系统疾病状态中被解释为表明氧气递送受损。我们建议通过测量在自行车测量机上持续载荷运动的过程中测量VO2动力学和心率动力学（心肺反应的描述符（心肺反应的描述符），以扩展NIDDM中VO2/工作负荷关系的研究。此外，我们将评估三个月的运动训练对这些参数的影响。患者将包括10名单纯NIDDM，10个体重和年龄与非糖尿病妇女和10个瘦年相匹配的非糖尿病妇女（以控制肥胖症的影响）的年绝经前女性。心脏速率动力学减慢的VO2动力学放慢速度会表明NIDDM中氧气递送的损害。这些研究的重要性是1）使用锻炼（氧气吸收动力学）使用氧气消耗和心率上升速率的测量，以确定NIDDM的人与控制的人之间是否存在差异，以锻炼肌肉的锻炼以及2）在锻炼中锻炼的效果以及在锻炼中的效果，以进一步锻炼，并在锻炼中均具有差异。