PREVENTION OF ORAL CANCER BY TEA

通过茶预防口腔癌

• 批准号: 7719058
• 负责人: FUNG-LUNG CHUNG
• 金额: $ 57.69万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719058
• 关键词: Biological; Black Tea; Blood; Cells; Class; Clinic Visits; Computer Retrieval of Information on Scientific Projects Database; Control Groups; DNA Damage; Fatty Liver; Funding; Goals; Grant; Green tea; Incidence; Institution; Light; Malignant neoplasm of liver; Obesity; Oral; Participant; Placebos; Polyunsaturated Fatty Acids; Research; Research Personnel; Resources; Risk Factors; Role; Running; Sampling; Smoker; Source; Tea; United States National Institutes of Health; Urine; Water; Week; adduct; drinking; healthy volunteer; non-smoker; oral cancer prevention; oxidation; research clinical testing; treatment duration

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is for healthy volunteers. Participants will be divided into two groups: current smokers and a control group of non-smokers. In both groups, green tea and black tea, caffeinated water and water (placebo) will be drunk for 4 weeks each treatment with an initial 3-week run-in and 2-week "washout" period. During these treatment periods, oral cells will be collected weekly, urine samples weekly, and blood will be collected bi-weekly. Clinical evaluation of participants will be performed initially, then monthly. Participants will be required to visit the clinic once each week. The study will last, including treatments, 25 weeks. Our goal is to investigate the specific biological roles of one class of DNA damage formed by oxidation of polyunsaturated fatty acids called cyclic adducts in causing liver cancer. Incidences of liver cancer are on the rise in the U.S., and evidence indicates that obesity and fatty livers are potential risk factors. Therefore, our long-term goal is to generate information in order to shed light on possible mechanisms of obesity in liver cancer.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究是针对健康志愿者的。参与者将分为两组：当前的吸烟者和一组非吸烟者。在这两组中，绿茶和红茶，含咖啡因的水和水（安慰剂）将在每次治疗中醉酒4周，最初的3周磨合和2周的“洗手”期。在这些治疗期间，每周将每周收集口腔细胞，每周每两周收集血液。最初将对参与者进行临床评估，然后每月进行。参与者将每周一次去诊所。该研究将持续使用，包括治疗25周。 我们的目标是研究一类DNA损伤的特定生物学作用，该DNA损伤是由称为循环加合物的多不饱和脂肪酸氧化在引起肝癌中的。在美国，肝癌的发生率正在增加，证据表明肥胖和脂肪肝是潜在的危险因素。因此，我们的长期目标是生成信息，以阐明肝癌肥胖的可能机制。