TREATMENT OPTIONS FOR TYPE 2 DIABETES IN ADOLESCENTS AND YOUTH (TODAY)

青少年 2 型糖尿病的治疗方案（当今）

• 批准号: 7731316
• 负责人: DAVID M NATHAN
• 金额: $ 0.15万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7731316
• 关键词: Adolescent; Aerobic; Age; Behavior; Beta Cell; Body Composition; Cell physiology; Child; Computer Retrieval of Information on Scientific Projects Database; Diabetic Angiopathies; Family; Functional disorder; Funding; Grant; Individual; Institution; Insulin Resistance; Life Style; Metformin; Non-Insulin-Dependent Diabetes Mellitus; Physical activity; Quality of life; Research; Research Personnel; Resources; Safety; Source; Time; Today; Treatment Failure; Treatment Protocols; United States National Institutes of Health; Upper arm; Weight Gain; base; cardiovascular risk factor; cost effectiveness; fitness; glycemic control; nutrition; programs; psychological outcomes; response; rosiglitazone

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. TODAY will evaluate the safety and efficacy of three treatment regimens -- metformin alone; metformin plus rosiglitazone; and metformin plus a lifestyle program to reduce weight and increase physical activity -- by time to treatment failure based on glycemic control in children age 10-17 with Type 2 diabetes (Ty2DM). Secondary aims: compare and evaluate the arms' safety and cost- effectiveness; evaluate influence of individual and family behaviors on treatment response; and compare the arms' effects on pathophysiology of Ty2DM (beta cell function, insulin resistance, body composition, nutrition, physical activity, aerobic fitness, cardiovascular risk factors, microvascular complications, quality of life and psychological outcomes).

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 今天将评估三种治疗方案的安全性和功效 - 仅二甲双胍；二甲双胍加上罗西列酮；和二甲双胍加上生活方式计划，以减轻体重和增加体育锻炼 - 根据治疗失败的时间，基于2型糖尿病（TY2DM）的10-17岁儿童的血糖控制。次要目的：比较和评估武器的安全性和成本效益；评估个人和家庭行为对治疗反应的影响；并比较对TY2DM病理生理学的影响（β细胞功能，胰岛素抵抗，身体成分，营养，身体活动，有氧运动，心血管危险因素，微血管并发症，生活质量和心理结局）。