Improving Cardiorespiratory Fitness and Cardiometabolic Health among Children with Physical Disabilities through Movement-to-Music Telehealth with Arm-based Sprint-Intensity Interval Training

通过运动音乐远程医疗和基于手臂的冲刺强度间歇训练，改善身体残疾儿童的心肺健康和心脏代谢健康

• 批准号: 10645848
• 负责人: Byron Lai
• 金额: $ 22.28万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10645848
• 关键词: Address; Adherence; Adolescent; Adult; Adverse event; Aerobic; Aerobic Exercise; Age; Behavior; Behavioral; Blood; Blood Pressure; Body Composition; Body Weight; Body measure procedure; C-reactive protein; Cardiovascular Diseases; Cerebral Palsy; Child; Child Welfare; Cholesterol; Community Networks; Control Groups; Development; Disabled Children; Doctor of Philosophy; Dryness; Dual-Energy X-Ray Absorptiometry; Enrollment; Ensure; Equipment; Exercise; Exercise Physiology; Exercise Test; Fatty acid glycerol esters; Fingers; General Population; Glycosylated hemoglobin A; Health; Health Benefit; Health Professional; Home; Impairment; Insulin; Internet; Interval training; Intervention; Knowledge; Leg; Literature; Longevity; Measures; Metabolic; Metabolic syndrome; Methods; Modality; Modeling; Modification; Monitor; Movement; Music; Outcome; Oxygen Consumption; Participant; Pediatric Hospitals; Persons; Physical Education; Physical activity; Pilot Projects; Procedures; Process; Program Appropriateness; Random Allocation; Randomized; Randomized, Controlled Trials; Recovery; Research; Research Personnel; Rest; Roentgen Rays; Running; Safety; Sample Size; Schools; Site; Sphygmomanometers; Spirometry; Sports; Spottings; Supervision; Techniques; Testing; Thinness; Time; Tissues; Training Programs; Translating; Transportation; Triglycerides; Underserved Population; Video Recording; Visual; Waiting Lists; Walking; Wheelchairs; Work; aged; arm; cardiometabolic risk; cardiometabolism; cardiorespiratory fitness; cardiovascular disorder risk; cardiovascular fitness; cloud based; cohort; community organizations; coronavirus pandemic; design; disability; effectiveness trial; efficacy study; efficacy/implementation trial; empowerment; evidence base; exercise program; experience; fitness intervention; follow-up; functional disability; high risk; improved; innovation; mortality; mortality risk; novel; participant safety; physical inactivity; physically handicapped; portability; post intervention; pressure; prevent; programs; recruit; scale up; telehealth; telemonitoring

Byron Lai, PhD – R21 Project Summary/Abstract Due to alarmingly low rates of exercise participation, children with physical disabilities are at substantially high risk for cardiovascular disease (CVD), related conditions, and CVD mortality as they age into adulthood. Regular participation in aerobic exercise is an effective non-pharmaceutical method for preventing cardiovascular disease and metabolic syndrome, but effective modalities such as walking, running, and cycling are often not suitable for children with disabilities, who have impaired mobility. The growing availability of internet access and acceptance of telehealth (due to the coronavirus pandemic) create an unprecedented opportunity to engage large, underserved groups of children with disabilities in exercise behavior. However, ensuring that they maintain regular participation over periods of time that are necessary to elicit changes in cardiometabolic health will require enjoyable, accessible, and age-appropriate programs. This application proposes a pilot project that builds upon our recent feasibility work. The project will pilot an evidence-based, scale-up movement-to-music (M2M) program that has been newly revised for children with cerebral palsy who have functional impairments. The program includes three novel components: 1) pre-recorded videos that are stylized with visual graphics and enjoyable music to themes (e.g., superheroes, sports, pop music) that were requested by our feasibility participants; 2) arm-based routines with sprint-intensity interval training (SIT), based on principles from the latest exercise physiology research in the general population; and 3) replicable cloud-based tele-monitoring procedures. Participants will be recruited from a children’s hospital and network of community organizations. A total of 50 children with cerebral palsy will be randomized to one of two groups: 12 weeks of SIT-M2M or 12-week waitlist control that undergoes habitual activity before receiving SIT-M2M. The SIT prescription will include 3 sessions per week of 30 repeated sequences of 4-s of maximal arm exercise, with active recovery periods (~20-min sessions with a warm-up and cool down period). This study will compare changes between groups in outcomes related to cardiovascular fitness and core indicators of cardiometabolic health, namely, body composition, body weight, high sensitivity C-reactive protein, hemoglobin A1c, triglycerides, cholesterol, and blood pressure. Additionally, the study will record implementation metrics that will inform the design of a follow-up trial. Study findings will inform the development of a convenient telehealth efficacy trial for implementation across various sites and settings to improve the health and well- being of children with disabilities who cannot walk or stand for prolonged periods of time.

拜伦·莱（Byron Lai）博士 - R21 项目摘要/摘要 由于运动率令人震惊，身体疾病的儿童处于明显的高度 随着年龄的增长，心血管疾病（CVD），相关状况和CVD死亡率的风险。 定期参加有氧运动是一种有效的非药物方法 心血管疾病和代谢综合征，但有效的方式，例如步行，跑步和骑自行车 通常不适合流动性障碍的残疾儿童。日益增长的可用性 远程医疗的互联网访问和接受（由于冠状病毒大流行）创造了前所未有的 有机会让大型，服务不足的残疾儿童参与运动行为。然而， 确保他们在引起变化所必需的时间内保持定期参与 心脏代谢健康将需要愉快，可访问且适合年龄的程序。此应用程序 提案是一个基于我们最近的可行性工作的试点项目。该项目将试行一个基于证据的项目， 扩大运动到音乐（M2M）计划，该计划已针对患有脑瘫儿童的新修订 有功能障碍。该程序包括三个新颖组成部分：1）预录的视频 用视觉图形和愉快的音乐风格为主题（例如超级英雄，体育，流行音乐） 我们的可行性参与者要求； 2）基于Sprint强度间隔训练（SIT）的基于ARM的例程， 基于一般人群最新的运动生理研究原则； 3）可复制 基于云的远程监控过程。参与者将从儿童医院和网络招募 社区组织。共有50名脑瘫儿童将被随机分为两组之一： 在接受SIT-M2M之前，进行了12周的SIT-M2M或12周的候补控制列表控制。 SIT处方将包括每周3个会话，包括30个重复序列的4-S最大臂的序列 锻炼，有积极的恢复期（约20分钟的疗程，有热身和冷却期）。这项研究会 比较小组之间在与心血管健康相关的结果和核心指标的变化 心脏代谢健康，即身体成分，体重，高灵敏度C反应蛋白，血红蛋白 A1C，甘油三酸酯，胆固醇和血压。此外，该研究将记录实施指标 这将为您的后续试验设计。研究结果将为您提供方便的发展信息 远程医疗效率试验，用于在各种站点和环境中实施，以改善健康和良好的健康 是残疾儿童，他们不能长时间走路或站立。