Gene-Environment Interplay in Alcoholism

酗酒中基因与环境的相互作用

基本信息

批准号：
7923059
负责人：
ANDREW C. HEATH
金额：
$ 18.45万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-05 至 2013-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7923059
关键词：
21 year old Address Adolescence Adult Age Age Distribution Age Reporting Alcohol abuse Alcohol consumption Alcohol dependence Alcohol or Other Drugs use Alcoholism Alcohols Antisocial Personality Disorder Anxiety Disorders Area Attention Attention deficit hyperactivity disorder Australia Bayesian Method Behavior Birth Blood Blood specimen Budgets Candidate Disease Gene Child Childhood Chromosome Mapping Cohort Studies Collection Commit Comorbidity Complex DNA Data Data Analyses Data Set Dependence Development Diagnosis Diagnostic Disease Disease remission Divorce Drug usage Drunk driving Early-life trauma Eating Disorders Ensure Environment Environmental Exposure Environmental Risk Factor Epidemiologic Methods Equation Ethnic Origin Etiology Event Factor Analysis Faculty Familiarity Family Fathers Female Frequencies Funding Gender Generations Genes Genetic Genetic Research Genetic Risk Genotype Goals Growth Heavy Drinking Heritability Illicit Drugs Individual Interest Group Interview Intoxication Journals Knowledge Laws Lead Life Literature Longevity Major Depressive Disorder Marital Status Markov Chains Marriage Measures Mediator of activation protein Medical Mentors Methods Missouri Modeling Molecular Epidemiology Mothers Neighborhoods Nursery Schools Obesity Occupational Outcome Panic Disorder Parenting behavior Parents Patient Self-Report Pattern Perception Pharmaceutical Preparations Post-Traumatic Stress Disorders Probability Psychopathology Recording of previous events Recovery Recurrence Reporting Reproduction Request for Applications Research Research Personnel Research Project Grants Residual state Resolution Risk Risk Factors Role Saliva Sample Size Sampling Schools Screening procedure Secondary to Siblings Social Phobia Staging Statistical Methods Substance Use Disorder Surveys Symptoms TNFRSF5 gene Telephone Telephone Interviews Testing Time Tobacco Toddler Trauma Twin Multiple Birth Update Variant Weight Woman Work Workplace age effect alcohol use disorder base cohort college comparison group cost depression design deviant divorce/separation drinking early adolescence early onset emerging adulthood environmental change follow-up gene discovery genetic association genetic epidemiology genetic variant genome wide association study genome-wide high risk human subject improved informant interest next generation offspring pediatric trauma peer problem drinker programs prospective sex simulation skills stressor trait transmission process trend

项目摘要

DESCRIPTION (provided by applicant): This K05 application requests 5 years of support to allow the PI to commit protected time and effort to his research and mentoring program focused on gene-environment interplay and risk-mechanisms in alcoholism, freeing him from the encroachment of administrative responsibilities. The Pi's mentoring will engage 4 junior faculty in the pursuit of independence as NIAAA-funded R01 investigators, in the substantive areas of (i) offspring environmental risks and socioemotional problems associated with parental alcoholism, and comorbidity during the toddler and preschool years, (ii) etiology of very early-onset alcohol and other substance use, with a particular focus on risk-mechanisms associated with parental divorce/never marriage, (iii) transitions in alcohol use and problems from adolescence through young adulthood, particularly the impact of childhood assaultive trauma, and (iv) personal and offspring outcomes, and risk-factors, associated with remission versus recovery of alcohol problems in women with recurrent drunk driving. These diverse research areas are well-matched with the Pi's long-standing interests in (i) alcoholism in women, and (ii) the environmental contexts in which the genetic transmission of alcoholism risk occurs. Additionally, the PI will continue his contributions to the alcoholism field through R01-supported projects which involve (i) follow-up at age 30 of MOAFTS, a birth cohort of female like-sex twin pairs followed from median age 15 to identify mediators and moderators of genetic influences on onset of and recovery from versus persistence in alcohol problems; (ii) continued follow-up of the Australian Children-of-Twins cohorts, contrasting outcomes associated with maternal or paternal alcoholism (high environmental risk, high genetic risk) versus alcoholism only in parent's MZ co-twin (reduced environmental risk, high genetic risk), or DZ co-twin (intermediate genetic risk) and controls; and (iii) methodologic contributions and secondary data-analyses that take advantage of the coordinated assessments, and informativeness about environmental and gene environmental interplay mechanisms, of studies in the Australian twin register and MOAFTS (including the availability of ATR genome-wide association data on 4000 individuals). Understanding environmental contexts for the genetic inheritance of alcoholism should improve both understanding of how to identify and intervene with groups at high-risk for problems, and gene-discovery.

描述（由申请人提供）：该K05申请要求提供5年的支持，以使PI能够为他的研究和指导计划投入受到保护的时间和精力，重点是酒精中毒中的基因 - 环境相互作用和风险机理，从而使他免于侵占行政责任。 PI的指导将与4个初级教师一起追求独立性，作为NIAAA资助的R01调查人员，在（i）后代的环境风险和与父母酒精中毒的后代环境风险和社会情感问题的实质领域，以及在幼儿园和其他早期善用的企业中，（ii）涉及的企业，（ii）与偶然性相关的，（ii）涉及的企业，以及其他企业，（ii）与机器相关的焦点，并与一家人机器相关联，并与一家人机器相关联。离婚/永不结婚，（iii）饮酒和从青春期到成年期的问题，尤其是儿童攻击性创伤的影响，以及（iv）个人和后代结果，以及与缓解与康复相关的妇女与酒精问题相关的妇女问题相关的风险因素。这些多样化的研究领域与PI对妇女的酒精中毒的长期利益相匹配，以及（ii）酒精中毒风险发生的环境传播的环境环境。此外，PI将通过R01支持的项目继续他对酒精中毒领域的贡献，涉及（i）30岁的MoAfts的随访，这是15岁中位数的女性类似于性别的双胞胎对的出生队列，以识别中位数的中位数和遗传影响的调解人，对酒精含量的遗传影响和康复均在酒精问题中恢复；（ii）仅在父母的MZ Co-Twin（降低环境风险，高遗传风险）或DZ Co-Twin（中介遗传风险）和控制症（中间的遗传风险）和控制中，与仅在父母的MZ Co-Twin（降低环境风险，高遗传风险）和对比中的酒精中毒相关的澳大利亚儿童群岛，与母亲或父亲酒精中毒（高环境风险，高遗传风险）相关的结果对比；（iii）利用协调评估的方法学贡献和次要数据 - 纳尔病，以及有关澳大利亚双胞胎登记册和MOAFT的研究的有关环境和基因环境相互作用机制的信息（包括4000个人对全基因组基因组的可用性）。了解酒精中毒的遗传遗传的环境环境应提高人们对高风险问题的识别和干预的理解，以及基因发现。