ALCOHOL USE DISORDER IN YOUNG WOMEN: GENETIC EPIDEMIOLOGY: MOAFTS WAVE 7

年轻女性酒精使用障碍:遗传流行病学:MOAFTS 第 7 波

基本信息

  • 批准号:
    8137324
  • 负责人:
  • 金额:
    $ 63.35万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-09-30 至 2014-08-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): We propose a wave seven telephone diagnostic interview follow-up of the MOAFTS (Missouri Adolescent Female Twin Study) young cohorts A and B (target N=2100 twin interviews), and for some participants who have not yet provided samples, saliva sample collection (target N=840) for genotyping for zygosity confirmation. MOAFTS is a prospective study of a birth cohort of female like-sex twin pairs (N=370 African- American pairs, N=1999 European/Other Ancestry pairs) identified from birth records and first assessed in adolescence, at median age 16. Goals of the project are to characterize, in a broadly representative general population female twin cohort, gene-environment interplay in alcoholism and associated substance use disorders, focusing on (i) parental alcoholism and its associated twin offspring environmental risk-exposures and outcomes, and (ii) the development and course of female drinking and alcohol-related problems, as well as other substance use and problems (particularly tobacco use and dependence), through adolescence into young adulthood, emphasizing precursors/mediators and moderators of genetic and environmental effects on both onset of and recovery from problems. In the most recent data-collection, interviews were completed with approximately 3500 respondents at ages 21-30. Wave seven will provide a further follow-up of alcohol and other substance use and problems, and proximal environmental exposures, so that most twins are through their period of greatest risk for onset of alcohol problems, and the sample will be old enough to be informative about the predictors of remission versus persistence of alcohol problems and heavy drinking (target N=700 assessed at age 30, N=1400 assessed at age 28/N=100 new dependence cases). Our research is motivated by the concern that the genetic transmission of risks of alcohol and other substance use disorders frequently occurs in the context of high-risk environmental exposures commonly associated with parental alcoholism - including interpersonal conflict and divorce or never-cohabitation, step-parent presence, childhood assaultive trauma, family socioeconomic disadvantage - risks that need not be reduced by the departure of an alcoholic parent from the home. Through completion of the wave seven data-collection and data-analyses, our goals are to understand how these early environmental exposures, in combination with genetic effects, influence onset and course of heavy drinking and alcohol problems, either directly, or through effects on timing of onset of alcohol use and on comorbid substance use, and effects on subsequent adult role changes of the twins (early or delayed parenting; relationship formation, conflict and dissolution; education completion, employment, and adult peer relationships); and to identify other variables (history of childhood or adolescent-onset psychopathology, other substance use disorders) that may mediate or moderate these relationships. Current understanding of the genetic epidemiology of female alcohol use disorders is based largely on either retrospective or underpowered studies - a gap that the MOAFTS cohort will help to fill. PUBLIC HEALTH RELEVANCE: Alcohol misuse by young women is associated with significant impairments including difficulties in forming and maintaining stable romantic relationships, delayed reproduction, and impaired parenting, as well as risks associated with hazardous use. Better understanding of risk-mechanisms leading to the onset and persistence versus remission of female alcohol misuse in adolescence and young adulthood will have important implications for motivating and better targeting prevention and intervention efforts for young women and, in some cases, mitigating risks to their children.
描述(由申请人提供):我们提出了七个电话诊断访谈的随访(密苏里州青少年女性双胞胎研究)年轻同伙A和B(目标n = 2100个双胞胎访谈),对于一些尚未提供样本样本的参与者,saliva样本收集(目标n = 840)用于Zygusity的基因分类。 MoAfts是一项对女性类似性的双胞胎对出生队列的前瞻性研究(n = 370个非洲裔美国对,n = 1999年欧洲/其他祖先对),从出生记录中确定并在青春期首次评估,在中位数16岁时。关于(i)父母酒精中毒及其相关的双子后代环境风险曝光和结果,以及(ii)女性饮酒和与酒精有关的问题的发展和过程,以及其他物质的使用和问题(尤其是烟草使用和依赖性),通过青春期进入年轻人的青春期,强调前卫者/中世纪和环境的效果和环境的效果,并强调了对杂志和环境的效果的效果和环境的效果。在最新的数据收集中,访谈与21-30岁的大约3500名受访者完成了访谈。 Wave seven will provide a further follow-up of alcohol and other substance use and problems, and proximal environmental exposures, so that most twins are through their period of greatest risk for onset of alcohol problems, and the sample will be old enough to be informative about the predictors of remission versus persistence of alcohol problems and heavy drinking (target N=700 assessed at age 30, N=1400 assessed at age 28/N=100 new dependence cases).我们的研究的激励是,人们担心酒精和其他物质使用障碍的遗传传播经常发生在通常与父母酒精中毒相关的高风险环境暴露范围内,包括人际冲突和离婚或从未离婚,离婚,离婚,儿童攻击,儿童攻击,社会经济性偏见的风险不受家庭经验的风险 - 不适合造成的风险。通过完成浪潮七个数据收集和数据 - 数据,我们的目标是了解这些早期的环境暴露如何与遗传效应结合,重大饮酒和酒精问题的影响和过程,或通过对酒精使用时间的影响以及对合并症的效果以及对共生毒品的使用以及对成人的成年人的作用以及对成人的成人作用的影响(以及对成人的成年人的关系)的影响(同伴关系);并确定可能介导或调节这些关系的其他变量(儿童期或青少年发作的精神病理学,其他药物使用障碍)。当前对女性酒精使用障碍遗传流行病学的理解主要基于回顾性或能力不足的研究 - MoAfts队列将有助于填补这一空白。公共卫生相关性:年轻妇女滥用酗酒与重大障碍有关,包括在形成和维持稳定的浪漫关系,延迟繁殖和育儿受损以及与危险使用相关的风险方面遇到困难。更好地了解导致青春期和成年年轻人滥用女性酒精滥用的风险机制将对激励和更好地针对年轻妇女的预防和干预工作具有重要意义,在某些情况下,减轻了对孩子的风险。

项目成果

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ANDREW C. HEATH其他文献

ANDREW C. HEATH的其他文献

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{{ truncateString('ANDREW C. HEATH', 18)}}的其他基金

Enriching Alcoholism Cohort and Population Studies
丰富酗酒队列和人口研究
  • 批准号:
    8933925
  • 财政年份:
    2016
  • 资助金额:
    $ 63.35万
  • 项目类别:
Enriching Alcoholism Cohort and Population Studies
丰富酗酒队列和人口研究
  • 批准号:
    9756247
  • 财政年份:
    2016
  • 资助金额:
    $ 63.35万
  • 项目类别:
Enriching Alcoholism Cohort and Population Studies
丰富酗酒队列和人口研究
  • 批准号:
    9338111
  • 财政年份:
    2016
  • 资助金额:
    $ 63.35万
  • 项目类别:
NEIGHBORHOOD, FAMILY AND INDIVIDUAL FACTORS IN ADOLESCENT DRINKING
青少年饮酒的邻里、家庭和个人因素
  • 批准号:
    8506595
  • 财政年份:
    2013
  • 资助金额:
    $ 63.35万
  • 项目类别:
NEIGHBORHOOD, FAMILY AND INDIVIDUAL FACTORS IN ADOLESCENT DRINKING
青少年饮酒的邻里、家庭和个人因素
  • 批准号:
    8728703
  • 财政年份:
    2013
  • 资助金额:
    $ 63.35万
  • 项目类别:
ALCOHOL USE DISORDER IN YOUNG WOMEN: GENETIC EPIDEMIOLOGY: MOAFTS WAVE 7
年轻女性酒精使用障碍:遗传流行病学:MOAFTS 第 7 波
  • 批准号:
    7730499
  • 财政年份:
    2009
  • 资助金额:
    $ 63.35万
  • 项目类别:
ALCOHOL USE DISORDER IN YOUNG WOMEN: GENETIC EPIDEMIOLOGY: MOAFTS WAVE 7
年轻女性酒精使用障碍:遗传流行病学:MOAFTS 第 7 波
  • 批准号:
    7939575
  • 财政年份:
    2009
  • 资助金额:
    $ 63.35万
  • 项目类别:
ALCOHOL USE DISORDER IN YOUNG WOMEN: GENETIC EPIDEMIOLOGY: MOAFTS WAVE 7
年轻女性酒精使用障碍:遗传流行病学:MOAFTS 第 7 波
  • 批准号:
    8317639
  • 财政年份:
    2009
  • 资助金额:
    $ 63.35万
  • 项目类别:
ALCOHOL USE DISORDER IN YOUNG WOMEN: GENETIC EPIDEMIOLOGY: MOAFTS WAVE 7
年轻女性酒精使用障碍:遗传流行病学:MOAFTS 第 7 波
  • 批准号:
    8527625
  • 财政年份:
    2009
  • 资助金额:
    $ 63.35万
  • 项目类别:
GENE-ENVIRONMENT INTERPLAY IN ALCOHOLISM
酗酒中的基因与环境相互作用
  • 批准号:
    8581767
  • 财政年份:
    2008
  • 资助金额:
    $ 63.35万
  • 项目类别:

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