Health, Aging and Body Composition Study

健康、衰老和身体成分研究

• 批准号: 7732406
• 负责人: Tamara B. Harris
• 金额: $ 32.46万
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7732406
• 关键词: African American; Aging; Ancillary Study; Behavioral; Biological Markers; Body Composition; Cardiovascular Diseases; Cardiovascular system; Cessation of life; Condition; Dementia; Diabetes Mellitus; Disease; Disease susceptibility; Elderly; Event; Fatty acid glycerol esters; Fracture; Genetic; Health; Hospitalization; Knee Osteoarthritis; Lung diseases; Malignant Neoplasms; Measurement; Measures; Mental Depression; Metabolic Diseases; Motor Skills; Muscle; Osteoporosis; Outcome; Outcome Study; Parents; Pathway interactions; Pennsylvania; Physical Function; Population; Race; Reporting; Sex Characteristics; Site; Surveys; Telephone; Tennessee; Walking; Weight; Woman; X-Ray Computed Tomography; aged; bone; cognitive function; cohort; design; functional decline; functional disability; loss of function; member; men; muscle strength

The Health, Aging, and Body Composition Study (Health ABC) is a longitudinal cohort of 3,075 men and women, aged 70-79 at baseline in 1997-98, and includes 552 African American men and 729 African American women. At baseline, all cohort members reported no difficulty walking 1/4 mile or up ten steps. The study sites are Memphis, Tennessee and Pittsburgh, Pennsylvania. The study was designed to investigate how changes in body composition (muscle, fat, and bone) act as a common pathway through which weight-related health conditions and behavioral factors contribute to loss of function. Race and gender differences and similarities over the ten years of the study have been key to understanding health trajectories as the cohort has aged. The study measurements include weight-related health conditions such as diabetes and metabolic disorders, osteoporosis, osteoarthritis of the knee, cardiovascular disease, pulmonary disease, and depression. Body composition was repeatedly measured with both dual energy x-ray absorptiometry and computerized tomography. We also assessed muscle strength, and physical function, as well as an extensive set of biomarkers. The major outcome of the study is persistent difficulty walking 1/4 mile or stair climbing reported over a 6-month period. Other outcomes include cardiovascular events, cancers, fractures, dementia, diabetes, hospitalizations, and deaths.

健康，衰老和身体成分研究（健康ABC）是一个由3,075名男女组成的纵向队列，在1997 - 98年的基线为70-79岁，包括552名非裔美国人和729名非裔美国妇女。 在基线时，所有队列成员均报告步行1/4英里或上升十步没有困难。 研究地点是孟菲斯，田纳西州和宾夕法尼亚州匹兹堡。 该研究旨在研究身体成分（肌肉，脂肪和骨骼）的变化如何起到与体重相关的健康状况和行为因素有助于丧失功能的通用途径。 在研究的十年中，种族和性别差异和相似之处是随着队列的老化而了解健康轨迹的关键。 研究的测量包括与体重相关的健康状况，例如糖尿病和代谢性疾病，骨质疏松症，膝盖骨关节炎，心血管疾病，肺部疾病和抑郁症。 通过双能X射线吸收仪和计算机断层扫描反复测量身体成分。 我们还评估了肌肉力量和身体机能，以及广泛的生物标志物。 这项研究的主要结果是在6个月内持续难以行走1/4英里或攀登楼梯攀爬。 其他结果包括心血管事件，癌症，骨折，痴呆，糖尿病，住院和死亡。

项目成果

Estimation of macular pigment optical density in the elderly: test-retest variability and effect of optical blur in pseudophakic subjects.

老年人黄斑色素光密度的估计：人工晶状体受试者的重测变异性和光学模糊的影响。

• DOI: 10.1016/j.visres.2007.01.013
• 发表时间: 2007
• 期刊: Vision research
• 影响因子: 1.8
• 作者: Gallaher,KevinT;Mura,Marco;Todd,WmAndrew;Harris,TarshaL;Kenyon,Emily;Harris,Tamara;Johnson,KarenC;Satterfield,Suzanne;Kritchevsky,StephenB;Iannaccone,Alessandro;HealthABCStudy
• 通讯作者: HealthABCStudy

From bedside to bench: research agenda for frailty.

• DOI: 10.1126/sageke.2005.31.pe24
• 发表时间: 2005-08-03
• 期刊: Science of aging knowledge environment : SAGE KE
• 作者: Fried, Linda P;Hadley, Evan C;Ferrucci, Luigi
• 通讯作者: Ferrucci, Luigi