Measurement of IL-6 & Mediators of Inflamation in the CHS and WHAS

IL-6的测定

• 批准号: 6431501
• 负责人: Tamara B. Harris
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6431501
• 关键词: blood coagulation; cardiovascular disorder; cardiovascular function; cell adhesion molecules; clinical research; cytoskeletal proteins; dimer; epidemiology; human mortality; human subject; inflammation; interleukin 6; outcomes research; plasmin; vascular endothelium

To continue our work on inflammation, we contracted with Dr. Russell Tracey to measure IL-6, D-dimer, Plasmin-alpha-2-antiplasmin, and ICAM-1, in the Cardiovascular Health Study (CHS) on subjects who died of causes other than cardiovascular disease. The CHS has a major case/cohort study to examine the association of IL-6 and the above analytes with cardiovascular outcomes. We have contracted with the Cardiovascular Health Study Coordinating Center to analyze all-cause mortality, both cardiovascular and non-cardiovascular mortality to see if similar factors predict other mortality, particularly cancer related mortality and to see if this association is mediated by markers of endothelial dysfunction and activation of coagulation available in CHS.Analysis should begin on about October 1, 2000.

为了继续进行炎症，我们与罗素·特雷西（Russell Tracey）博士签约，以测量心血管卫生研究（CHS）对死于心血管疾病以外的病因的受试者的IL-6，d-二聚，质蛋白-Alpha-2-抗血清素和ICAM-1。 CHS有一项主要的病例/队列研究，用于检查IL-6和上述分析物与心血管结局的关联。我们已经与心血管健康研究中心签约，以分析心血管和非心血管死亡率的全因死亡率，以查看类似的因素是否预测了其他死亡率，尤其是与癌症相关的死亡率，并查看这种关联是否是由内皮功能障碍和凝结型在Chs.analsisy中可用的辅助症的标记介导的。