2023 Cell Biology of Megakaryocytes and Platelets Gordon Research Conference and Gordon Research Seminar

2023巨核细胞和血小板细胞生物学戈登研究会议暨戈登研究研讨会

• 批准号: 10608747
• 负责人: ALESSANDRA BALDUINI
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-15 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10608747
• 关键词: Academia; Address; Area; Basic Science; Biogenesis; Biology; Blood Coagulation Disorders; Blood Platelet Disorders; Blood Platelets; Bone Marrow; Cardiovascular Diseases; Cells; Cellular biology; Clinical; Coagulation Process; Collaborations; Communication; Complex; Congenital Disorders; Coupled; Data; Dedications; Development; Devices; Diagnosis; Disease; Disseminated Malignant Neoplasm; Engineering; Enhancers; Environment; Feedback; Fostering; Functional disorder; Future; Goals; Growth; Hematological Disease; Hematopoiesis; Hematopoietic stem cells; Hemorrhage; Hemostatic function; Immunity; Inflammation; Influentials; Inherited; International; Malignant Neoplasms; Megakaryocytes; Mentors; Mission; Molecular; Myeloproliferative disease; Neoplasm Metastasis; Outcome; Pathogenicity; Pathway interactions; Patients; Platelet Count measurement; Play; Prevention; Process; Production; Publications; Recording of previous events; Research; Research Personnel; Risk; Role; Signal Transduction; Stem Cell Development; Surface; Thrombopoiesis; Thrombopoietin; Thrombosis; Update; career; cell type; design; diagnostic tool; experience; hematopoietic stem cell differentiation; improved; leukemia; lymphatic development; meetings; mimetics; new technology; novel; novel therapeutics; platelet function; prevent; receptor function; seal; symposium; therapeutic target; tumor; wound healing

PROJECT SUMMARY / ABSTRACT The biennial Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) on the Cell Biology of Megakaryocytes and Platelets brings together current leaders, junior investigators and trainees working on the development and disorders of the megakaryocyte lineage. It is the premier international meeting in the field. Our scientific mission is to bridge the gap between researchers working on different aspects of the lineage, i.e. hematopoietic stem cells, megakaryocytes and platelets. This mission is more relevant than ever, as the interdependence between each cell type becomes increasingly clear, e.g. the role of megakaryocytes in stem cell development, and the impact of inflammation on megakaryocyte growth and platelet production. The overarching, aim of the GRC is to allow current and emerging leaders of the field to communicate unpublished data, thereby educating colleagues, promoting discussions and fostering collaborations. Specifically, the aims are to: 1. Highlight the extraordinary progress being made in our understanding of platelet function in the context of hemostasis, thrombosis, and inherited/ congenital platelet disorders. Talks will cover the state-of-the-art on platelet surface receptor function and control of coagulation, intracellular signaling, the development of new targets for antiplatelet therapy, and immense progress in diagnosis and treatment of platelet function disorders. 2. Discuss the latest unpublished research on the engineering of devices and approaches to evaluate platelet function and how platelets can be used in therapy and as diagnostic tools. 3. Evaluate newly described mechanisms of megakaryocyte maturation and platelet production. It is increasingly apparent that platelet production is a complex multifactorial process controlled by super enhancers as well as the bone marrow microenvironment. In a dedicated session, we will discuss this unique interplay between the megakaryocyte lineage and other cells in the bone marrow environment. 4. Discuss studies that push the field into new directions, including updates on new regulators of hematopoiesis and thrombopoiesis, new technologies to study platelets on a single cell level and in high throughput functional omics, and a dedicated session to discuss newly identified critically influential roles for platelets in metastatic cancer, and megakaryocytes in leukemias and myeloproliferative disorders. To optimize interaction between researchers, and based on feedback from past conferences, we have designed most sessions so that they feature talks on both platelets and megakaryocytes. We also decided to continue with a new format that was first implemented in 2017, with the incorporation of 11 short talks to be selected from abstracts embedded within each of the main sessions (eliminating the dedicated hot topics session). The strengths of applying cross-disciplinary approaches to research questions will be emphasized throughout the whole meeting, and both basic science and translational aspects of the field will be discussed.

项目摘要 /摘要 双年展戈登研究会议（GRC）和戈登研究研讨会（GRS）关于细胞生物学 巨核细胞和血小板汇集了当前的领导者，初级调查员和受训者 巨核细胞谱系的发展和疾病。这是国际首屈一指的会议 场地。我们的科学任务是弥合研究人员在研究不同方面的研究人员之间的差距 谱系，即造血干细胞，巨核细胞和血小板。这个任务比以往任何时候都更有意义 随着每种细胞类型之间的相互依赖性变得越来越清晰，例如巨核细胞在 干细胞的发育以及炎症对巨核细胞生长和血小板产生的影响。这 总体，GRC的目标是允许该领域的现任和新兴领导者交流未出版的 数据，从而对同事进行教育，促进讨论并促进合作。 具体而言，目的是： 1。强调在我们对血小板功能的理解中所取得的非凡进步 止血，血栓形成和遗传/先天性血小板疾病。会谈将涵盖最新的 血小板表面受体功能和凝结，细胞内信号的控制，新的发展 抗血小板疗法的靶标，以及血小板功能障碍诊断和治疗方面的巨大进展。 2。讨论有关设备和方法评估血小板工程的最新未发表的研究 功能以及如何将血小板用于治疗和诊断工具。 3。评估新描述的巨核细胞成熟和血小板产生的机制。这是 越来越明显的是，血小板的产生是由超级增强剂控制的复杂多因素过程 以及骨髓微环境。在专门的会议中，我们将讨论这个独特的相互作用 在骨髓环境中的巨核细胞谱系和其他细胞之间。 4。讨论将领域推向新方向的研究，包括有关新监管机构的更新 造血和血小板，新技术在单个细胞水平上研究血小板 吞吐量功能轨迹和专门的会议，讨论新发现的重要影响力的角色 转移性癌症中的血小板和白血病和骨髓增生性疾病的巨核细胞。 为了优化研究人员之间的互动，并根据过去会议的反馈，我们有 设计了大多数会议，以便它们在血小板和巨核细胞上都具有演讲。我们还决定 继续采用新的格式，该格式于2017年首次实施，并结合了11次简短谈判 从每个主要会议中嵌入的摘要中选择（消除专用的热门话题 会议）。将强调将跨学科方法应用于研究问题的优势 在整个会议中，将讨论该领域的基础科学和翻译方面。