Influence of Adipose Tissue on Adjacent Muscle

脂肪组织对邻近肌肉的影响

• 批准号: 7592103
• 负责人: Tamara B. Harris
• 金额: $ 20.69万
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7592103
• 关键词: Adipose tissue; Age; Back; Biometry; Biopsy; Body Composition; Demography; Epidemiology; Fatty acid glycerol esters; Gender; Gene Expression; Goals; Laboratories; Maintenance; Muscle; Muscle function; Obesity; Population; Population Study; Procedures; Protocols documentation; Purpose; Race; Time; Tissues; Visceral; Work; disability; medically necessary care; muscle strength; wasting

There are many unanswered questions regarding maintenance of muscle and muscle function in old age. The Laboratory of Epidemiology, Demography and Biometry has organized several large population studies targeted to understanding, on a population level, factors that influence the relationship between body composition, particularly muscle, and strength over time. These studies have been successful in allowing identification of new hypotheses regarding factors that might influence the course of disability, including the observation that fat infiltrates into muscle, both in obesity and in disuse. Further population work has shown that the amount of muscle fat may vary by gender and race and that muscle fat increases with age, but at a later age than visceral fat. However, little is known about how fat actually influences muscle, especially with regard to gene expression. The purpose of this project is to establish a study to obtain fat from the muscles of the back.

关于老年肌肉和肌肉功能的维持有许多未解决的问题。 流行病学，人口统计学和生物特征的实验室已经组织了一些大型人群研究，该研究旨在理解人群水平，这些因素会影响身体成分，尤其是肌肉和随着时间的推移力量之间的关系。 这些研究已经成功地允许鉴定有关可能影响残疾进程的因素的新假设，包括观察到脂肪渗入肌肉，无论是在肥胖还是在失败中。 进一步的人口工作表明，肌肉脂肪的量可能因性别和种族而异，并且肌肉脂肪随着年龄的增长而增加，但比内脏脂肪更晚。 然而，关于脂肪实际影响肌肉的知之甚少，尤其是在基因表达方面。 该项目的目的是建立一项研究，以从背部的肌肉中获取脂肪。