Muscle Attentuation in Training and Detraining of Older Adults

老年人训练和停止训练时的肌肉衰减

• 批准号: 7732407
• 负责人: Tamara B. Harris
• 金额: $ 5.6万
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7732407
• 关键词: Age; Australia; Biometry; Body Composition; Clinical; Contract Services; Demography; Elderly; Epidemiology; Exercise; Fatty acid glycerol esters; Floor; Gender; Goals; Image; Infiltration; Intervention; Laboratories; Leg; Maintenance; Measurement; Measures; Methods; Movement; Muscle; Muscle function; Obesity; Pattern; Population; Population Study; Protocols documentation; Purpose; Queensland; Race; Resistance; Scanning; Secondary to; Testing; Thigh structure; Time; Training; Universities; Upper arm; Visceral; Walking; Work; X-Ray Computed Tomography; attenuation; bone; disability; muscle hypertrophy; muscle strength; performance tests; response

There are many unanswered questions regarding maintenance of muscle and muscle function in old age. The Laboratory of Epidemiology, Demography and Biometry has organized several large population studies targeted to understanding, on a population level, factors that influence the relationship between body composition, particularly muscle, and strength over time. These studies have been successful in allowing identification of new hypotheses regarding factors that might influence the course of disability, including the observation that fat infiltrates into muscle, both in obesity and in disuse. Further population work has shown that the amount of muscle fat may vary by gender and race and that muscle fat increases with age, but at a later age than visceral fat. However, little is known about how fat actually influences muscle. The purpose of this professional services contract is to obtain computerized tomography scans of the muscle, bone and fat in the arms and leg at three points in time in a clinical intervention: at the time of maximum muscle hypertrophy secondary to intervention, at the end of a period of deconditioning, and at the end of a period of intensive reconditioning. Dr. Dennis Taaffe of the University of Queensland,Brisbane, Australia, and his colleagues have established a protocol to test the hypothesis that a high-velocity progressive resistance training will increase measures of muscle function to a greater extent than a conventional progressive resistance training protocol. The protocol established contains extensive measurements of muscle response to interventions as is indicated below: dynamic muscle strength using the one repetition maximum (1RM) method, muscle endurance at 70% of 1RM, peak and average muscle power as well as velocity of movement, and a battery of physical performance tests (floor rise to standing, stair climb, 6-m backwards walk, 6-m usual and fast walk, chair rise, 400-m walk, and functional reach). Dr. Harris's project adds a CT imaging protocol to Dr. Taeffe's study for 20 subjects at three time points during the course of the study. Through imaging of muscle mass we will quantify muscle hypertrophy and assess the extent to which the exercise interventions might influence muscle attenuation and muscle fat.

关于老年肌肉和肌肉功能的维持有许多未解决的问题。 流行病学，人口统计学和生物特征的实验室已经组织了一些大型人群研究，该研究旨在理解人群水平，这些因素会影响身体成分，尤其是肌肉和随着时间的推移力量之间的关系。 这些研究已经成功地允许鉴定有关可能影响残疾进程的因素的新假设，包括观察到脂肪渗入肌肉，无论是在肥胖还是在失败中。 进一步的人口工作表明，肌肉脂肪的量可能因性别和种族而异，并且肌肉脂肪随着年龄的增长而增加，但比内脏脂肪更晚。 但是，关于脂肪实际影响肌肉的了解知之甚少。 该专业服务合同的目的是在临床干预下以三个时间点在手臂和腿部的肌肉，骨骼和脂肪中获得计算机化的层析成像扫描：在经过干预的最大最大肌肉肥大时，在对条件的结束期结束时，以及一段密集的重新调节时期。 澳大利亚昆士兰州昆士兰州大学的丹尼斯·塔夫（Dennis Taaffe）博士及其同事建立了一项协议，以检验以下假设：高速渐进性渐进性训练将在更大程度上提高肌肉功能的衡量标准，而不是传统的渐进抵抗训练方案。 The protocol established contains extensive measurements of muscle response to interventions as is indicated below: dynamic muscle strength using the one repetition maximum (1RM) method, muscle endurance at 70% of 1RM, peak and average muscle power as well as velocity of movement, and a battery of physical performance tests (floor rise to standing, stair climb, 6-m backwards walk, 6-m usual and fast walk, chair rise, 400-m walk, and functional 抵达）。 在研究过程中，哈里斯博士的项目在Taeff博士的研究中为20个受试者的研究增加了CT成像方案。 通过肌肉质量的成像，我们将量化肌肉肥大，并评估运动干预可能影响肌肉衰减和肌肉脂肪的程度。

项目成果

Alterations in muscle attenuation following detraining and retraining in resistance-trained older adults.

• DOI: 10.1159/000182084
• 发表时间: 2009
• 期刊: Gerontology
• 影响因子: 3.5
• 作者: Taaffe DR;Henwood TR;Nalls MA;Walker DG;Lang TF;Harris TB
• 通讯作者: Harris TB