Measurement Of Interleukin 6 And C Reactive Protein In S

S 中白细胞介素 6 和 C 反应蛋白的测定

• 批准号: 6674334
• 负责人: Tamara B. Harris
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6674334
• 关键词: acute phase protein; aging; clinical research; cortisol; human subject; inflammation; interleukin 6; longitudinal human study; outcomes research

Summary of Work: The MacArthur Study of Successful Aging represents a unique opportunity to assess the relationship between interleukin-6 (IL-6) and cortisol and to examine whether the IL-6-health outcome risks would be modified by cortisol over a longer follow-up period. Follow-up on the MacArthur cohort now extends through 1996 and of the original cohort, approximately one-quarter have now died. We measured IL-6 and C-reactive protein (CRP) on frozen plasma samples. We investigated the cross-sectional relationship of urinary cortisol to IL-6 and CRP and found that there was no association. Both IL-6 and CRP were related to all-cause mortality and urinary cortisol did not modify this association. The data have been used to evaluate the relationship of albumin and IL-6 and also to examine the association of IL-6 with cognitive decline. In addition, we examined the cross-sectional and longitudinal association with performance and found a relationship only with change in walking speed. We are seeking collaborative associations with other scientists to examine the relationship with uric acid and also to group the MacArthur data with other data resources to examine infections, smoking and other variables of interest. Analysis of these data continues. Several papers have been submitted by Dr. David Reuben and Dr. Teresa Seeman from their work with the cytokine data.

工作摘要：成功衰老的麦克阿瑟研究代表了评估白介素6（IL-6）和皮质醇之间关系的独特机会，并检查较长的随访期间，皮质醇是否会通过皮质醇来修改IL-6健康结果风险。麦克阿瑟队列的后续行动现在一直延续到1996年，最初的队列中，大约四分之一的人已经死亡。我们在冷冻血浆样品上测量了IL-6和C反应蛋白（CRP）。我们研究了尿皮质醇与IL-6和CRP的横截面关系，发现没有关联。 IL-6和CRP都与全因死亡率有关，尿皮质醇没有改变这种关联。该数据已用于评估白蛋白和IL-6的关系，并检查IL-6与认知能力下降的关联。此外，我们研究了与性能的横截面和纵向关联，并发现仅与步行速度变化的关系。我们正在寻求与其他科学家的合作关联，以检查与尿酸的关系，并将MacArthur数据与其他数据资源分组，以检查感染，吸烟和其他感兴趣的变量。这些数据的分析仍在继续。 David Reuben博士和Teresa Seeman博士通过Cytokine数据提交了几篇论文。