Heterogeneous Effects of Education on Alzheimers Disease and Related Dementia among Demographic Groups: A Multigenerational and Multilevel Study

教育对人口群体中阿尔茨海默病和相关痴呆症的异质性影响：一项多代、多层次的研究

• 批准号: 10512877
• 负责人: Liying Luo
• 金额: $ 36.23万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10512877
• 关键词: Address; Adult; Affect; Alzheimer' s disease related dementia; Baby Booms; Biosocial; Birth; Black Populations; Characteristics; Child; Cohort Analysis; County; Data; Data Set; Data Sources; Disadvantaged; Education; Ethnic group; Exposure to; Family; Family member; Future; Generations; Goals; Health and Retirement Study; Hispanic Populations; Impaired cognition; Individual; Inequality; Longitudinal Studies; Measures; Mediating; Mediation; Mediator of activation protein; Methodology; Not Hispanic or Latino; Parents; Pathway interactions; Pattern; Population; Population Process; Public Health; Research; Research Design; Research Personnel; Resources; Respondent; Risk Factors; Role; Schools; Social Environment; Time; cohort; college; contextual factors; dementia risk; disparity reduction; ethnic difference; ethnic minority population; health data; improved; innovation; insight; intergenerational; novel; novel strategies; population health; protective effect; racial and ethnic; racial and ethnic disparities; racism; sociodemographic disparity; sociodemographic factors; socioeconomics; supportive environment; tool

PROJECT SUMMARY The protective effect of education against Alzheimer’s disease and related dementias (ADRD) is found to be smaller for racial/ethnic minority individuals than for non-Hispanic White individuals. Identifying factors that modify or mediate the education-ADRD relationship presents a unique opportunity to address the racial/ethnic disparities in ADRD and ultimately improve population health. However, most research relies on respondents’ education to assess the education-ADRD relationship, failing to consider the roles of other family member’s education or the social context and environment in which education occurs and affects ADRD. The major goal of the proposed research is to develop a novel framework that incorporates multigenerational education and multidomain contextual measures and use it to clarify the heterogeneous effects of education on ADRD risk among racial/ethnic groups by analyzing nationally representative longitudinal data. We propose to achieve this goal through three specific aims. In Aim 1, we will develop a multigenerational framework and use it to estimate the effect of multigenerational education on the respondent’s ADRD risk and the racial/ethnic disparities. Aim 2 is to construct multidomain contextual measures of structural inequality and racism and estimate their effects on individual’s ADRD risk and the racial/ethnic disparities. To provide historical and population contexts for understanding results from Aims 1 and 2, in Aim 3 we will estimate how education effects on ADRD risk may differ across four birth cohorts. The proposed research is significant because it will help reduce racial/ethnic disparities in cognitive impairment and ADRD risk by clarifying multigenerational pathways and identifying mediators and modifiers of the heterogeneous education-ADRD relationships among demographic groups. The proposed research is innovative because it will develop a new multigenerational and multilevel mediation approach to understanding why the education-ADRD risk relationship differs among racial/ethnic groups. It will also contribute new contextual data to a nationally representative data set.

项目概要 研究发现，教育对阿尔茨海默病和相关痴呆症 (ADRD) 的保护作用是 少数族裔/族裔个体的影响小于非西班牙裔白人个体的影响因素。 修改或调解教育-ADRD 关系为解决种族/族裔问题提供了独特的机会 ADRD 的差异并最终改善人口健康然而，大多数研究依赖于受访者的情况。 教育来评估教育与ADRD关系，没有考虑其他家庭成员的角色 教育或教育发生并影响 ADRD 的社会背景和环境 主要目标。 拟议研究的目的是开发一个新颖的框架，将多代教育和 多领域背景测量，并用它来阐明教育对 ADRD 风险的异质影响 我们建议通过分析具有全国代表性的纵向数据来实现这一目标。 在目标 1 中，我们将开发一个多代框架并用它来估计。 多代教育对受访者 ADRD 风险和种族/民族差异的影响 目标 2。 是构建结构性不平等和种族主义的多领域背景衡量标准，并评估其对 个人的 ADRD 风险和种族/民族差异 提供历史和人口背景。 了解目标 1 和 2 的结果后，在目标 3 中，我们将估计教育对 ADRD 风险的影响如何 四个出生队列之间存在差异。 拟议的研究意义重大，因为它将有助于减少认知障碍方面的种族/民族差异 和 ADRD 风险，通过阐明多代途径并确定调节因素和调节因素 人口群体之间的异质教育-ADRD 关系。 创新，因为它将开发一种新的多代和多层次的调解方法来理解 为什么教育与 ADRD 风险关系在种族/族裔群体中存在差异，这也将带来新的贡献。 将上下文数据转换为具有全国代表性的数据集。