Cohort Differences in Cognitive Impairment and Alzheimer Disease and Related Dementias: Education Effects and Sex Differences

认知障碍和阿尔茨海默病及相关痴呆症的队列差异：教育影响和性别差异

基本信息

批准号：
10341121
负责人：
Liying Luo
金额：
$ 16.05万
依托单位：
PENNSYLVANIA STATE UNIVERSITY, THE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-02-15 至 2024-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10341121
关键词：
Age Alzheimer disease prevention Alzheimer&apos s disease related dementia Area Award Baby Booms Biological Factors Biosocial Birth Characteristics Cognition Cognitive Cohort Analysis Cohort Effect Data Data Analyses Dementia Demographer Detection Development Diagnosis Disease Education Funding Future Goals Health and Retirement Study Heterogeneity Impaired cognition Incidence Information Distribution Investigation Life Cycle Stages Longitudinal cohort Longitudinal cohort study Methodology Methods Modeling National Longitudinal Survey of Youth Outcome Pathway interactions Pattern Periodicals Population Positioning Attribute Prevalence Prevention Process Public Health Research Research Design Research Personnel Respondent Risk Factors Sampling Schools Sex Differences Social Processes Time Training Variant Woman age related aging population analytical tool base career cognitive development cohort experience improved innovation insight interdisciplinary collaboration longitudinal dataset men novel protective factors sex social social factors trend

项目摘要

Project Summary The prevalence rates of cognitive impairment and Alzheimer's disease and related dementias (ADRD) is projected to rise as the population ages, but the trends may be altered by the demographic process of cohort replacement. Determining the relative contribution of population aging, periodical shift, and cohort process to the overall trend is thus critical for accurate estimation and projection of the prevalence and incidence rates of cognitive impairment and ADRD. However, the field lacks a valid method for assessing the unique effects of cohort membership. The major goal of the proposed research is to develop a novel method and analyze multi-cohort longitudinal datasets to identify cohort variations and sex differences in cognitive impairment and ADRD and how education effects vary between cohorts and sex groups. Aim 1 is to develop a much-needed age-period-cohort model to accurately and reliably estimate cohort differences in cognitive impairment and ADRD. Aim 2 is to determine sex differences in cognitive impairment and ADRD between and within cohorts. The proposed investigation in Aim 2 will help identify a set of risk and protective factors separately for men and women. Aim 3 is to elucidate the degree to which education effects on cognition and ADRD may differ between birth cohorts and between men and women. The proposed research in Aim 3 will provide important clues about how education may interact with age-related changes in cognitive and non-cognitive processes to delay the onset and development of ADRD. The project is innovative in that the methodological development can produce reliable and efficient estimates of cohort-related variations. The estimation accuracy of cohort effects on cognition and ADRD is further improved by leveraging multiple longitudinal cohort studies and by borrowing distribution information for small samples. The proposed research will also analyze two longitudinal datasets for the Baby Boom cohorts to assess their life-course pathways to cognitive impairment and ADRD. The PI has expertise in cohort analysis and demographic process. The co-I is a neuroscientist and specialized in the areas of ADRD-related biosocial factors. The project's interdisciplinary team has necessary methodological and substantive areas of expertise and is thus ideally positioned to accomplish Aims 1-3.

项目概要认知障碍和阿尔茨海默病及相关痴呆 (ADRD) 的患病率预计会随着人口老龄化而上升，但这一趋势可能会因人口变化过程而改变队列替换。确定人口老龄化、周期变化和队列的相对贡献因此，总体趋势的过程对于准确估计和预测患病率和认知障碍和 ADRD 的发生率。然而，该领域缺乏有效的评估方法群体成员资格的独特影响。拟议研究的主要目标是开发一种新颖的方法和分析多队列纵向数据集，以确定队列变异和性别差异认知障碍和 ADRD 以及教育效果在不同群体和性别群体之间的差异。目标1 是开发一个急需的年龄阶段队列模型来准确可靠地估计队列差异认知障碍和ADRD。目标 2 是确定认知障碍的性别差异队列之间和队列内的 ADRD。目标 2 中拟议的调查将有助于识别一系列风险和分别针对男性和女性的保护因素。目标 3 是阐明教育的程度对认知和 ADRD 的影响可能因出生队列以及男性和女性而异。这目标 3 中拟议的研究将为教育如何与年龄相关的相互作用提供重要线索认知和非认知过程的改变可延缓 ADRD 的发生和发展。该项目的创新之处在于方法的开发可以产生可靠和高效的结果队列相关变化的估计。队列效应对认知和 ADRD 的估计准确度为通过利用多个纵向队列研究和借用分布信息进一步改进对于小样品。拟议的研究还将分析婴儿潮的两个纵向数据集队列来评估他们的认知障碍和 ADRD 的生命历程路径。 PI 拥有队列分析和人口统计过程方面的专业知识。同事是一位神经科学家专门研究ADRD相关的生物社会因素领域。该项目的跨学科团队拥有必要的方法论和实质性专业领域，因此非常适合完成目标 1-3。