Viral Testing

病毒检测

• 批准号: 10647888
• 负责人: CARLOS A SARIOL
• 金额: $ 82.18万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10647888
• 关键词: Adolescent; Algorithms; Animals; Biochemistry; Biological Assay; Biological Markers; Biological Models; Biological Sciences; Biomedical Research; Breeding; Caribbean region; Caring; Collaborations; Communities; Data; Disease; Funding; Genetic; Geographic Locations; Goals; HIV; HIV/AIDS; Human; Human Resources; Individual; Institution; International; Intuition; Island; Macaca mulatta; Maintenance; Medical; Methodology; Modeling; Modification; Monkeys; Occupational Health; Peer Group; Physiology; Primates; Protocols documentation; Research; Resources; Risk; SIV; STLV-3; Safety; Science; Simian Retroviruses; Source; Testing; United States National Institutes of Health; Viral; Virus; arm; diagnostic algorithm; driving force; germ free condition; improved; nonhuman primate; operation; programs; research and development; therapeutic development; virology

PROJECT SUMMARY/ABSTRACT: The major goal of this application is to sustain the Specific Pathogen Free (SPF) program at the Caribbean Primate Research Center's (CPRC) through support of operations, administration, veterinary care, virological and MHC typing and by the improvement of our comprehensive genetic management plan. A unique feature of CPRC animals in favoring a successful establishment and sustainable of SPF colony are that these animals are naturally free of SIV and SRV-D, two of the four viruses to be tested for. Nevertheless, for safety and as required for the SPF Program, we continue systematically testing for all four viruses (B virus, STLV, SIV and SRV-D). The Program provides unadmixed Indian-origin rhesus monkeys with defined genetic and virological background. The primary purpose of the virology testing arm of CPRC-SPF breeding program is to assure that its Indian- origin rhesus macaque colony, supporting NIH-sponsored research specially on HIV/AIDS, is free of the above- mentioned viruses. An advantage of this program is that it has been closed to external individuals since 2015. Certainly, this aspect substantially decreases the risks of the re-introduction of any of the four tested viruses from an external source.

项目概要/摘要： 此应用程序的主要目标是维持加勒比海地区的无特定病原体 (SPF) 计划 灵长类动物研究中心 (CPRC) 通过运营、管理、兽医护理、病毒学支持 MHC 分型以及我们综合遗传管理计划的改进。一个独特的特点是 CPRC 动物有利于 SPF 群体的成功建立和可持续发展，因为这些动物是 天然不含 SIV 和 SRV-D（待检测的四种病毒中的两种）。尽管如此，为了安全并根据需要 对于 SPF 计划，我们继续对所有四种病毒（B 病毒、STLV、SIV 和 SRV-D）进行系统测试。这 该计划提供具有明确遗传和病毒学背景的纯印度产恒河猴。 CPRC-SPF 育种计划病毒学检测部门的主要目的是确保其印度- 支持美国国立卫生研究院资助的专门针对艾滋病毒/艾滋病的研究的原产地恒河猴群体不存在上述情况： 提到的病毒。该计划的一个优点是自 2015 年以来一直不对外部个人开放。 当然，这方面大大降低了重新引入四种测试病毒中任何一种的风险。 外部来源。