Training Program in Translational Cardiovascular Research and Entrepreneurship

转化心血管研究和创业培训计划

基本信息

批准号：
10642864
负责人：
Daniel E Michele
金额：
$ 23.4万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10642864
关键词：
Cardiovascular system Entrepreneurship Research Training Programs

项目摘要

Abstract This renewal proposal seeks continued funding for the Training program in Translational Cardiovascular Research and Entrepreneurship (CVRE) at the University of Michigan. Cardiovascular disease is the leading cause of death worldwide. The mission of this program is to train the next generation of PhD scientists seeking careers in cardiovascular research in the ethical development and application of research results from the laboratory to the bedside, with the ultimate goal of improving therapy for patients. The proposed training program is intentionally designed to address the gap in training of young basic scientists and pre-doctoral students in key areas of translational cardiovascular research such as preclinical research design, drug discovery, device/therapy development, optimization and testing, research entrepreneurship, and regulatory compliance. The interdisciplinary and internationally recognized faculty of this program provides an outstanding training environment that includes state of the art facilities and techniques spanning genetic, molecular, cellular, systems, engineering and clinical investigation of both vascular and cardiac diseases. By capitalizing on the existing strengths of our faculty in basic, preclinical, and translational cardiovascular research, and unique academic resources at the University of Michigan, we will train students not only in state of the art biomedical research, but also in applying systems biology for preclinical testing, navigating regulatory compliance, and the process and challenges of research entrepreneurship. Therefore, this program offers students a unique comprehensive and immersive educational experience in translational research training. The added benefit is that the program will also prepare students for the diversity of scientific careers available to and often pursued by young scientists including academic research, start-up companies, biotechnology and large pharmaceutical and device companies. The Translational CVRE program will attract trainees at the PhD Candidate level from laboratories across the Frankel Cardiovascular Center faculty membership, from exceptionally strong graduate programs in the medical school wide Program in Biomedical Sciences, and the College of Engineering and School of Pharmacy. Funds are requested for 5 trainee slots per year, and students may be reappointed for a second year by competitive renewal. The key program features are 1) strong, fundamental basic research training on translationally relevant research topics under the NHLBI mission 2) training in preclinical research design and phenotypic testing 3) didactic and experiential learning on research entrepreneurship along with career path relevant skills development. By placing students at the interface between basic cardiovascular research, biomedical engineering, and cardiovascular medicine, we hope to better prepare the next generation of PhD scientists to be leaders at taking basic research discoveries and being capable of directing their path to the clinic.

抽象的该更新提案寻求持续资助转化心血管培训计划密歇根大学研究与创业（CVRE）。心血管疾病是首要全世界的死亡原因。该计划的使命是培养下一代博士科学家寻求心血管研究的职业发展以及研究成果的应用实验室到床边，最终目标是改善患者的治疗。拟议的培训该计划旨在解决年轻基础科学家和博士前培训方面的差距转化心血管研究关键领域的学生，如临床前研究设计、药物发现、设备/疗法开发、优化和测试、研究创业和监管遵守。该项目的跨学科和国际认可的教师提供了出色的培训环境，包括最先进的设施和技术，涵盖遗传、血管和心脏病的分子、细胞、系统、工程和临床研究。经过利用我们教师在基础、临床前和转化心血管方面的现有优势密歇根大学的研究和独特的学术资源，我们不仅在州内培养学生艺术生物医学研究，而且还应用系统生物学进行临床前测试，引导监管合规性，以及研究创业的过程和挑战。因此，该计划提供学生在转化研究培训中获得独特的全面和身临其境的教育体验。额外的好处是，该计划还将帮助学生为多样化的科学职业做好准备年轻科学家经常追求的目标，包括学术研究、初创公司、生物技术和大型制药和设备公司。转化型 CVRE 项目将吸引博士生来自弗兰克尔心血管中心教职人员实验室的候选级别，来自医学院生物医学科学项目中非常强大的研究生项目，以及工程学院和药学院。每年需要为 5 个实习生名额申请资金，并且学生可以通过竞争性续约获得第二年的连任。程序的主要特点是 1) 强有力的、基础性的基础研究培训，涉及转化相关的研究主题 NHLBI 任务 2) 临床前研究设计和表型测试培训 3) 教学和研究创业以及职业道路相关技能的体验式学习发展。通过将学生置于基础心血管研究、生物医学研究之间的交叉点工程和心血管医学，我们希望更好地准备下一代博士科学家成为基础研究发现的领导者，并能够指导其走向临床。

项目成果

期刊论文数量（31）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Sarcolemma wounding activates dynamin-dependent endocytosis in striated muscle.

肌膜损伤激活横纹肌中动力依赖的内吞作用。

DOI：
发表时间：
2021-01
期刊：
影响因子：
0
作者：
McDade, Joel R;Naylor, Molly T;Michele, Daniel E
通讯作者：
Michele, Daniel E

Development of activated endothelial targeted high-density lipoprotein nanoparticles.

开发活化内皮靶向高密度脂蛋白纳米颗粒。

DOI：
发表时间：
2022
期刊：
影响因子：
0
作者：
Yu, Minzhi;Hong, Kristen;Adili, Reheman;Mei, Ling;Liu, Lisha;He, Hongliang;Guo, Yanhong;Chen, Y Eugene;Holinstat, Michael;Schwendeman, Anna
通讯作者：
Schwendeman, Anna

HDL in Endocrine Carcinomas: Biomarker, Drug Carrier, and Potential Therapeutic.

内分泌癌中的 HDL：生物标志物、药物载体和潜在治疗。