Function Core - Core C

功能核心-核心C

基本信息

批准号：
10459376
负责人：
Daniel E Michele
金额：
$ 14.57万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-01 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10459376
关键词：
Address Affect Age Animal Disease Models Animal Model Animal Organ Animals Attention Basic Science Biology Biomechanics Biophysics Cartilage Collaborations Communities Complement Data Analyses Data Analytics Disease Disease Outcome Engineering Environment Equipment Experimental Designs Financial Support Fostering Funding Genetic Genomics Goals Growth Health Histology Human Human Development Inbred Strain Individual Injury Knowledge Laboratories Lead Leadership Ligaments Measurement Measures Mechanics Methodology Michigan Molecular Muscle Muscle function Musculoskeletal Musculoskeletal Development Musculoskeletal Diseases Musculoskeletal System Organ Organism Pathogenesis Pathology Pathway interactions Phenotype Physiology Proteomics Reproducibility Research Research Design Research Personnel Research Project Grants Resolution Resources Rodent Scientist Services Specificity Standardization Structure Surgical Models Techniques Technology Tendon structure Testing Time Tissue Banks Tissue imaging Training Universities animal tissue base bone cost experience experimental study improved in vivo innovation multimodal data multimodality neuromuscular function new technology novel pre-clinical assessment pre-clinical research preclinical study response to injury sex soft tissue targeted treatment therapeutic evaluation therapy outcome tissue regeneration tool

项目摘要

Michigan Integrative Musculoskeletal Health Core Center – Core C Project Summary Discovery of new targets and treatments for musculoskeletal diseases requires a deep understanding of the basic biology of musculoskeletal development and function, rigorous research into the fundamental mechanisms of disease pathogenesis, and robust testing of therapeutic targets and therapies aimed at improving disease outcome. Research using animal models is a cornerstone of these efforts enabling the study of organ and integrative organism function, the impact of environment, age, sex, and genetics on disease, and testing therapies and outcomes with disease-relevant measures. The ability to study musculoskeletal phenotypes across a wide-ranging scale of animal models requires considerable expertise and highly specialized training in physiology, biophysics, and engineering, as well as access to costly, high-resolution, state-of-the-art equipment. While occasionally the expertise and equipment for single approaches can be developed in a single laboratory, developing these approaches can be cost prohibitive, redundant, and can lead to proliferation of non-uniform techniques across the field. Rigorous and reproducible basic and preclinical research also requires robust experimental planning that can span multi-modal testing platforms from cellular and organ level function to in vivo physiology testing, in order to provide a fully comprehensive measure of phenotype or disease pathology. In cross-disciplinary research, innovation often arises from collaborations that extend beyond the limits of expertise in individual investigator laboratories alone. The overall long-term goal of the Function Core (Core C) of the Michigan Integrative Musculoskeletal Health Center (MiMHC) is to provide state-of-the-art animal and organ level phenotyping resources at the University of Michigan that can be used by the entire musculoskeletal research community, regardless of individual expertise. The Core brings together the leadership and technical experts in the physiology and biomechanics of the musculoskeletal system to provide fully staffed, specialized laboratory approaches to musculoskeletal biology including whole animal in vivo phenotyping and surgical models of musculoskeletal disease, and state-of-the-art measurements in bone mechanics, muscle function and mechanics, tendon mechanics, and neuromuscular function. Further emphasis on training and sharing of new technologies, standardization, and collaboration will expand the impact of Core C for our users and the broader musculoskeletal research community.

密歇根综合肌肉骨骼健康核心中心 – 核心 C 项目概要发现肌肉骨骼疾病的新靶点和治疗方法需要深入了解肌肉骨骼发育和功能的基础生物学，对基本机制的严格研究疾病发病机制的研究，以及旨在改善疾病的治疗靶点和疗法的稳健测试使用动物模型进行的研究是这些努力的基石，使器官和器官的研究成为可能。综合有机体功能，环境、年龄、性别和遗传对疾病的影响以及测试研究肌肉骨骼表型的能力。跨越大范围的动物模型需要大量的专业知识和高度专业化的培训生理学、生物物理学和工程学，以及昂贵、高分辨率、最先进的设备。虽然有时可以在单个实验室中开发单一方法的专业知识和设备，开发这些方法可能成本过高、多余，并可能导致非统一的扩散严格且可重复的基础和临床前研究也需要强大的技术。实验规划可以跨越从细胞和器官水平功能到内部的多模式测试平台体内生理学测试，以提供表型或疾病病理学的全面综合测量。在跨学科研究中，创新往往源于超越学科界限的合作功能核心（核心 C）的总体长期目标。密歇根综合肌肉骨骼健康中心 (MiMHC) 的目标是提供最先进的动物和密歇根大学的器官水平表型资源可供整个肌肉骨骼系统使用研究社区，无论个人专业知识如何，核心都汇集了领导力和技术。肌肉骨骼系统生理学和生物力学专家，提供人员齐全、专业的肌肉骨骼生物学的实验室方法，包括整个动物体内表型分析和手术肌肉骨骼疾病模型以及骨力学、肌肉功能和骨力学方面最先进的测量力学、肌腱力学、神经肌肉功能进一步强调训练和分享。技术、标准化和协作将扩大 Core C 对我们用户和更广泛领域的影响肌肉骨骼研究团体。