Visualsonics Vevo 3100 Ultrasound Imaging

Visualsonics Vevo 3100 超声成像

• 批准号: 10417498
• 负责人: Daniel E Michele
• 金额: $ 32.16万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10417498
• 关键词: 3-Dimensional; 4D Imaging; Aging; Anatomy; Aneurysm; Animal Model; Animals; Atherosclerosis; Blood Pressure; Blood Vessels; Cardiac; Cardiovascular Diseases; Color; Computer software; Disease; Disease model; Drug Delivery Systems; Electrocardiogram; Embryo; Equipment; Frequencies; Functional Imaging; Funding; Genetic Engineering; Heart; Image; Laboratory Animals; Longevity; Magnetic Resonance Imaging; Mechanics; Michigan; Modality; Mus; Neoplasms in Vascular Tissue; Oryctolagus cuniculus; Outcome; Pathogenesis; Phenotype; Physiological; Physiology; Preclinical Testing; Protocols documentation; Rattus; Request for Applications; Research Personnel; Resolution; Respiration; Rodent; Series; Services; Structure; Surgical Models; Telemetry; Three-Dimensional Imaging; Thrombosis; Time; Transducers; Tumor Volume; Ultrasonography; United States National Institutes of Health; Universities; Vascular Diseases; cost; end of life; experience; heart imaging; human disease; image reconstruction; imaging system; novel; novel therapeutics; operation; pre-clinical research; preclinical study; repaired; tool; ultrasound

Abstract Rodent animal models, including genetically engineered animals, surgical models, and naturally occurring disease models, remain the cornerstone of preclinical research, and are routinely used to study the mechanisms and pathogenesis of human disease and develop new therapies. High resolution ultrasound imaging is an essential phenotyping tool to be able to study internal animal anatomy and physiology non- invasively across the animal’s lifespan, during disease pathogenesis, and before or after preclinical testing of treatments. This SIG application requests funds to purchase a Visualsonics Vevo3100 Ultrasound Imaging System. This new imaging system will be essential to the operations of the Physiology Phenotyping Core, which has almost two decades of experience in providing ultrasound imaging to NIH funded investigators across the University of Michigan Campus. The new Vevo3100 will replace an aging Vevo 2100 that has reached its end of supported lifespan and routinely requires costly repairs. The Vevo3100 utilizes very high frequency linear array MX-series transducers that provide the highest resolution 2D and 3D imaging of small animal heart structure and function available, and also allow for quantitative, functional imaging of blood vessels and tumor volumes in animals as small as mouse embryos and up to large rats and rabbits. EKG and respiration gating and EKV Software provide unparalleled cine loop image reconstruction during the cardiac cycle at up to 10,000 frames per second, and enables a novel 4D Imaging Mode (3D + time) to capture 3D imaging of the heart during the cardiac cycle at near MRI levels of resolution but at a fraction of the time and cost. In addition, the VevoVasc imaging analysis and high-resolution color Doppler imaging provides a capability of analyzing consequences of vascular disease including aneurysms, atherosclerosis and the physiological effects of thrombosis. Importantly, the Vevo3100 will be incorporated into a robust, fully functional animal phenotyping core with expert ultrasound technical staff, an efficient recharge mechanism, standing animal protocols, procedural space, and laboratory animal support to ease access to novice or expert users across the university. The core also provides users access to surgical models of cardiovascular disease, telemetry recording, blood pressure, drug delivery and other phenotyping modalities which provide a pipeline for preclinical studies from disease models to experimental outcomes. For example, when combined with the blood pressure telemetry services available in the Physiology Phenotyping Core, VevoVasc allows for real-time non-invasive analysis of vascular wall mechanics. Overall, the Vevo3100 will allow the Physiology Phenotyping Core to provide new state of the art modes of functional ultrasound imaging to NIH funded users, and by replacing aging end-of-life equipment will allow the core to continue to provide ultrasound services to users into the next decade.

抽象的 啮齿类动物模型，包括基因工程动物、手术模型和自然发生的动物模型 疾病模型仍然是临床前研究的基石，并且通常用于研究 人类疾病的机制和发病机制并开发新的疗法。 成像是一种重要的表型分析工具，能够研究动物内部解剖学和生理学非 在动物的整个生命周期、疾病发病过程中以及临床前测试之前或之后 此 SIG 申请需要资金购买 Visualsonics Vevo3100 超声成像。 这种新的成像系统对于生理表型核心的运行至关重要， 在为 NIH 资助的研究人员提供超声成像方面拥有近二十年的经验 全新 Vevo3100 将取代老化的 Vevo 2100。 Vevo3100 已达到其支持的使用寿命，并且通常需要昂贵的维修费用。 频率线性阵列 MX 系列传感器，可提供小型物体的最高分辨率 2D 和 3D 成像 提供动物心脏结构和功能，并且还可以对血液进行定量、功能成像 小至小鼠胚胎，大至大鼠和兔子的血管和肿瘤体积。 呼吸门控和 EKV 软件在心脏骤停期间提供无与伦比的电影循环图像重建 以高达每秒 10,000 帧的速度循环，并启用新颖的 4D 成像模式（3D + 时间）来捕获 3D 在心动周期期间以接近 MRI 水平的分辨率对心脏进行成像，但所需时间仅为其一小部分 此外，VevoVasc 成像分析和高分辨率彩色多普勒成像提供了成本。 分析血管疾病后果的能力，包括动脉瘤、动脉粥样硬化和 重要的是，Vevo3100 将被纳入一个强大、全面的系统中。 功能性动物表型核心，专家超声技术人员，高效的充电机制， 常设动物方案、程序空间和实验动物支持，以方便新手或专家的接触 该核心还为整个大学的用户提供了心血管疾病的手术模型， 遥测记录、血压、药物输送和其他表型分析方式提供了管道 例如，与疾病模型和实验结果相结合的临床前研究。 生理学表型核心中提供的血压遥测服务，VevoVasc 允许实时 总体而言，Vevo3100 将允许生理学分析。 表型核心为 NIH 资助的用户提供最先进的功能性超声成像新模式， 通过更换老化的报废设备，核心将能够继续为以下人员提供超声服务： 用户进入下一个十年。