Heart-brain MRI for the evaluation of hemodynamic coupling in aging and Alzheimer's disease

心脑 MRI 用于评估衰老和阿尔茨海默氏病的血流动力学耦合

• 批准号: 10571411
• 负责人: Kelly Brooke Jarvis
• 金额: $ 12.41万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2027-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10571411
• 关键词: 3-Dimensional; 4D MRI; Abeta clearance; Acceleration; Adult; Affect; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease patient; Alzheimer' s disease related dementia; Aorta; Blood; Blood Flow Velocity; Blood Pressure; Blood Vessels; Blood flow; Brain; Brain imaging; Buffers; Cardiovascular system; Caregivers; Cerebrovascular Disorders; Cerebrum; Chest; Clinical; Cognitive aging; Complex; Coupling; Data; Dedications; Dementia; Development; Elderly; Evaluation; Foundations; Future; Goals; Head and neck structure; Heart; Hypertension; Imaging Techniques; Impairment; Individual; Lead; Link; Magnetic Resonance Imaging; Maps; Measures; Methodology; Methods; Neurons; Pathology; Pattern; Physiologic pulse; Physiological; Pilot Projects; Postdoctoral Fellow; Production; Protocols documentation; Pulsatile Flow; Quality of life; Radiology Specialty; Research; Scanning; Structure; Techniques; Training; White Matter Hyperintensity; brain abnormalities; brain magnetic resonance imaging; cardiovascular imaging; cardiovascular risk factor; cerebral atrophy; cerebrovascular; dementia risk; design; diagnostic tool; doctoral student; hemodynamics; improved; innovation; insight; middle age; modifiable risk; neuroimaging; normal aging; novel; novel strategies; physical inactivity; prevent; programs; tool

Project Summary/Abstract Cardiovascular risk factors have been implicated in Alzheimer's disease and related dementias, however, mechanisms underlying heart-brain hemodynamic coupling are not well understood. Aortic stiffening has been associated with increased dementia risk. In addition to brain changes typically associated with aging, cerebrovascular disease and Alzheimer's disease also affect vascular function and neuronal structure. However, the heart and brain are not usually evaluated in the same MRI exam, rather, in separate scanning sessions with highly specialized protocols focused on either cardiovascular or brain imaging. Recently, our group and others have established advanced MRI techniques to capture measures such as cardio- and cerebrovascular hemodynamics and brain structure in the same MRI exam. Measuring aortic hemodynamics (e.g., pulse wave velocity), together with intracranial pulsatility and brain abnormalities associated with cerebrovascular disease and Alzheimer's disease, will provide critical insights concerning underlying hemodynamic mechanisms. The proposed research will use advanced MRI techniques for comprehensive analysis of heart-brain hemodynamic coupling. This project will leverage new developments in cardiovascular imaging, particularly using 4D flow MRI, that enable full characterization of complex 3D hemodynamics, such as blood flow velocity, reverse flow mapping and aortic pulse wave velocity. Methodological advances in highly accelerated 4D flow MRI enable integration of cardiovascular and intracranial 4D flow MRI with quantitative structural analysis of the brain in a single MRI exam. This combined cardio- and cerebrovascular 4D flow MRI with quantitative brain imaging (i.e. “heart-brain MRI”) will be used to analyze hemodynamic coupling in aging and Alzheimer's disease. The goal of this proposal is to use novel heart-brain MRI to systematically evaluate hemodynamic coupling relationships in normal aging, and hypertension, and apply this technique in a pilot study of Alzheimer's disease. In Aims 1 and 2, heart-brain MRI will be evaluated in healthy adults and those with hypertension at both midlife and later life, to determine relationships between heart-brain MRI measures in normal aging and how hypertension may exacerbate brain changes with aging. In Aim 3, heart-brain MRI will be applied in a pilot study of Alzheimer's disease to examine preliminary relationships and help plan future studies. This K01 will provided training in clinical and neuroimaging aspects of aging and Alzheimer's disease to further the objective of building an independent research program focused on heart-brain hemodynamic coupling in cognitive aging and dementia, including that caused by Alzheimer's disease.

项目概要/摘要 心血管危险因素与阿尔茨海默病和相关痴呆症有关，然而， 主动脉硬化的机制尚不清楚。 除了通常与衰老相关的大脑变化之外， 脑血管疾病和阿尔茨海默病也会影响血管功能和神经结构。 心脏和大脑通常不会在同一次 MRI 检查中进行评估，而是在单独的扫描过程中进行评估 最近，我们的团队和其他人专注于心血管或大脑成像的高度专业化协议。 已经建立了先进的 MRI 技术来捕获心脑血管等指标 在同一 MRI 检查中测量主动脉血流动力学（例如脉搏波）。 速度），以及与脑血管疾病相关的颅内搏动和大脑异常 和阿尔茨海默病，将提供有关潜在血流动力学机制的重要见解。 拟议的研究将使用先进的 MRI 技术来综合分析心脑血流动力学 该项目将利用心血管成像的新发展，特别是使用 4D 流 MRI， 能够全面表征复杂的 3D 血流动力学，例如血流速度、逆流图 和主动脉脉搏波速度的高加速 4D 血流 MRI 方法的进步使得集成成为可能。 心血管和颅内 4D 流 MRI 的分析，并在单个 MRI 中对大脑进行定量结构分析 这项检查将心脑血管 4D 血流 MRI 与定量脑成像（即“心脑”）相结合。 MRI”）将用于分析衰老和阿尔茨海默氏病的血流动力学耦合。该提案的目标。 是利用新型心脑MRI来系统评估正常衰老过程中的血流动力学耦合关系， 和高血压，并将该技术应用于阿尔茨海默病的初步研究，目标 1 和 2，心脑。 将对健康成年人和中年和晚年患有高血压的人进行 MRI 评估，以确定 正常衰老过程中心脑 MRI 测量值与高血压如何使大脑恶化之间的关系 在目标 3 中，心脑 MRI 将应用于阿尔茨海默病的试点研究中进行检查。 建立初步关系并帮助规划未来的研究。该 K01 将提供临床和神经影像学方面的培训。 衰老和阿尔茨海默氏病的各个方面，以进一步实现建立独立研究计划的目标 专注于认知衰老和痴呆症中的心脑血流动力学耦合，包括由 阿尔茨海默病。