FASEB SRC: The Protein Phosphatases Conference

FASEB SRC：蛋白质磷酸酶会议

基本信息

批准号：
10468584
负责人：
Nunzio Bottini
金额：
$ 1.45万
依托单位：
FEDERATION OF AMER SOC FOR EXPER BIOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-01 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10468584
关键词：
Academia Achievement Affect American Area Attention Award Basic Science Biochemistry Biology COVID-19 pandemic California Cardiovascular Diseases Cell physiology Cellular biology Chemicals Clinical Trials Collaborations Communities Complement Development Drug Targeting Entrepreneurship Environment Enzymes Equilibrium Etiology Event Faculty Family Financial Support Fostering Funding Goals Grant Health Human Human Pathology Immune System Diseases Immune system Industrialization Industry International Investigation Japanese Japanese American Joints Knowledge Life Link Malignant Neoplasms Mediating Metabolic syndrome Minority Multienzyme Complexes Nervous system structure Nobel Prize North America Organ Participant Pathogenesis Pathologic Pharmaceutical Preparations Pharmacologic Substance Phosphoric Monoester Hydrolases Phosphorylation Postdoctoral Fellow Protein Kinase Protein phosphatase Regulation Request for Applications Research Research Personnel Resort Role Schedule Scientist Series Signal Transduction Societies Structure System Systems Biology Time Tissues Transferable Skills Translational Research Validation Woman Work career career networking cohort design early experience falls graduate student human disease improved insight interest lectures meetings minority scientist nervous system disorder new therapeutic target novel novel strategies posters protein function social stigma summer research symposium therapeutic target

项目摘要

ABSTRACT This application requests support for the 2022 edition of the Federation of American Societies for Experimental Biology (FASEB) Summer Research Conference on Protein Phosphatases. This conference will be the 16th edition of a recurring series of bi-annual meetings, the sole meeting in North America on this topic held continuously since 1990. Its 2020 edition had been awarded funding from NCI through R13 CA247237 (scored 26) but unfortunately the conference had to be cancelled because of the COVID-19 pandemic and the grant was returned to the NCI. We are planning now to re-organize it in 2022 as the first merger between the two longest-standing world phosphatase conferences: the FASEB protein phosphatase and the Japanese Association for Protein Phosphatase Research (JAPPR) Conference (at its 15th edition in 2022). The conference will provide an intense yet collegial environment for researchers to discuss and explore cutting-edge areas of current research on protein phosphatases and their roles in cellular biology and human pathology. The 2022 conference aims to 1) present the most current work on the structure, regulation and function of the protein phosphatases with particular attention to their roles in human disease; 2) highlight major achievements and new approaches, generate conduits to integrate them with other fields of research, and fuel interest in phosphatases as drug targets; and 3) to renew and refresh the community of phosphatase researchers engaging new and junior scientists and facilitating ties and collaboration between the FASEB and JAPPR phosphatase research communities. To achieve this, the 2022 conference is designed to cover the whole range of phosphatase science from basic to translational. Several scientific sessions are focused on the biochemistry and cell biology of some of the more than 1000 forms of these complex enzymes. Sessions dedicated to the role of protein phosphatases in diverse systems and organs—e.g. the nervous and immune systems- provide ideal platforms for cross- discussion of findings in normal vs pathological tissues and organs. Cancer will be a cross-cutting theme of the conference and will also be especially featured in two sessions and in the keynote lectures. Recent novel approaches have been progressively improving druggability of phosphatases, with multiple agents now in advanced clinical trials. Thus, another cross-cutting theme will be therapeutic targeting of phosphatases. Speakers will include experts from academia and industry, and talks on late-breaking advances and short talks selected from submitted abstracts will be given by new investigators, graduate students, post-doctoral fellows, and those from outside the field with a goal of increasing representation by women and minority scientists. The Omni Resort in Palm Springs provides a secluded venue that fosters informal interaction, discussion, and collaboration between the expected 150 participants. Altogether, the impact of the 2022 FASEB Conference on Protein Phosphatases will be to augment our understanding of fundamental protein phosphatase biology and pave the way for development of new therapies targeting phosphatases to improve human health.

抽象的本申请请求支持美国实验协会联合会 2022 年版生物学 (FASEB) 蛋白质磷酸酶夏季研究会议本次会议将是第 16 届。每年两次定期举行的系列会议的版本，这是北美就该主题举行的唯一会议自 1990 年以来一直持续。其 2020 年版通过 R13 CA247237 获得了 NCI 的资助（得分 26）但不幸的是，由于 COVID-19 大流行和我们现在计划在 2022 年对其进行重组，作为两者之间的首次合并。两个历史最悠久的世界磷酸酶会议：FASEB 蛋白磷酸酶会议和日本蛋白磷酸酶研究协会 (JAPPR) 会议（2022 年第 15 届）。会议将为研究人员提供一个激烈而学术的环境来讨论和探索前沿技术当前蛋白质磷酸酶的研究领域及其在细胞生物学和人类病理学中的作用。 2022 年会议的目标是 1) 展示有关蛋白质结构、调控和功能的最新工作磷酸酶，特别关注其在人类疾病中的作用；2）突出重大成就和新成果；方法，形成将其与其他研究领域相结合的渠道，并激发人们对磷酸酶的兴趣作为药物靶标；3) 更新和更新磷酸酶研究人员社区，吸引新的和青年科学家并促进 FASEB 和 JAPPR 磷酸酶研究之间的联系和合作为了实现这一目标，2022 年会议旨在涵盖磷酸酶科学的整个范围。从基础到转化，一些科学会议的重点是生物化学和细胞生物学。这些复杂酶的 1000 多种形式致力于蛋白质磷酸酶的作用。在不同的系统和器官中，例如神经和免疫系统，为跨系统提供了理想的平台。正常与病理组织和器官的研究结果的讨论将是该会议的一个交叉主题。会议，并将在两次会议和最近的小说主题演讲中特别突出。方法已逐步提高磷酸酶的成药性，目前有多种药物因此，另一个交叉主题将是磷酸酶的治疗靶向。演讲者将包括来自学术界和工业界的专家，并就最新进展进行演讲并进行简短的演讲从提交的摘要中选出的内容将由新研究人员、研究生、博士后研究员、以及来自该领域之外的人员，其目标是增加女性和少数族裔科学家的代表性。棕榈泉 Omni 度假村提供了一个僻静的场所，可促进非正式的互动、讨论和交流。预计 150 名参与者之间的合作，2022 年 FASEB 会议的影响。蛋白磷酸酶将增强我们对基本蛋白磷酸酶生物学的理解为开发针对磷酸酶的新疗法以改善人类健康铺平道路。