Modernization and Expansion of the University of Illinois at Chicago Animal-Based Research Program

伊利诺伊大学芝加哥分校动物研究项目的现代化和扩展

• 批准号: 10374588
• 负责人: Joanna Louise Groden
• 金额: $ 674.91万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-20 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10374588
• 关键词: Air Conditioning; Animal Experimentation; Animals; Area; Biological; Cancer Center; Cancer Patient; Cardiovascular Diseases; Caring; Chicago; Clinical; Clinical Research; Clinical Sciences; Communities; Disease; Elements; Entrepreneurship; Funding; Growth; Heating; Hospitals; Housing; Illinois; Institutes; Institution; Laboratories; Laboratory Animal Production and Facilities; Laboratory Animals; Link; Malignant Neoplasms; Metabolic; Metabolic Diseases; Mission; Modeling; Modernization; Mus; Organoids; Patients; Population Heterogeneity; Population Research; Pre-Clinical Model; Research; Resources; Sampling; Strategic Planning; System; Translational Research; United States National Institutes of Health; Universities; Xenograft Model; animal facility; base; clinical center; drug discovery; health disparity; human disease; human model; minority health; novel therapeutics; patient population; precision medicine; programs; treatment disparity; ventilation

Abstract The University of Illinois at Chicago (UIC) has developed highly recognized programs in health disparity research and is a national leader among urban, public institutions that provide care for diverse patient populations through its hospital and community-based clinical systems. Our UIC research programs have developed around our diverse populations and communities with a focus on understanding disease mechanisms, developing novel therapeutics and refining clinical approaches that have relevance to our patient base. Our preclinical modeling capability and laboratory animal research facilities now require expansion to link our research opportunities with the capability to generate and characterize models of human disease that support our core mission areas. UIC proposes to modernize and expand its animal-based research programs by performing critical renovations to the Biologic Resources Laboratory (BRL), the institution’s centralized animal facility. The project will comprise renovations and upgrades to essential elements of the heating ventilation and air conditioning (HVAC) and electrical systems in the BRL to increase housing capacity and accommodate growth in the institution’s murine- based cancer and metabolic research programs. These include a patient-derived organoid and xenograft modeling core that uses samples from underrepresented cancer patient populations and a new Metabolic Disease Core to model health disparities in the treatment of cardiovascular and metabolic diseases. Such modernization will also result in significant energy efficiencies. Overall, UIC BRL improvements will support animal-based research and permit the expansion of our translational and clinical research programs in health disparities and drug discovery. The long-term impact of the UIC BRL expansion will sustain our programs of translational excellence in health disparities research and drug discovery while permitting the growth of our NIH- funded population-based research programs (All of Us within the Illinois Precision Medicine Consortium, UIC Institute for Minority Health Research, and our CTSA-supported Center for Clinical and Translational Sciences) and our UI Cancer Center. This expansion will also impact the research programs of our regional partners who rely upon our facilities, cores and capability in animal research. Finally, our entrepreneurship-based strategic plan and for-profit partnerships to drive drug discovery initiatives have also compelled the expansion of our animal-based preclinical modeling capabilities.

抽象的 伊利诺伊大学芝加哥分校 (UIC) 在健康差异研究方面开发了备受认可的项目 并且是城市公共机构中的全国领导者，通过以下方式为不同的患者群体提供护理 我们的 UIC 研究项目是围绕我们的医院和社区临床系统开发的。 不同的人群和社区，重点是了解疾病机制、开发新的 与我们的患者基础相关的治疗方法和改进的临床方法。 现在需要扩大能力和实验动物研究设施，以将我们的研究机会与 能够生成和表征支持我们核心任务领域的人类疾病模型。 提议通过对 该项目将包括生物资源实验室（BRL），该机构的集中动物设施。 对供暖、通风和空调 (HVAC) 的基本要素进行翻新和升级，以及 BRL 中的电力系统，以增加住房容量并适应该机构小鼠的增长 这些包括基于患者的类器官和异种移植物。 建模核心使用代表性不足的癌症患者群体的样本和新的代谢 疾病核心，用于模拟心血管和代谢疾病治疗中的健康差异。 总体而言，UIC BRL 的改进将支持现代化改造，从而显着提高能源效率。 基于动物的研究，并允许扩展我们在健康方面的转化和临床研究项目 UIC BRL 扩张的长期影响将维持我们的项目。 健康差异研究和药物发现方面的卓越转化，同时允许我们的 NIH 发展 资助的基于人群的研究项目（伊利诺伊州精准医学联盟内的所有人，UIC 少数族裔健康研究所和 CTSA 支持的临床和转化科学中心） 以及我们的爱荷华大学癌症中心的扩建也将影响我们区域合作伙伴的研究项目。 最后，依靠我们在动物研究方面的设施、核心和能力。 推动药物发现计划的计划和营利性合作伙伴关系也迫使我们扩大 基于动物的临床前建模能力。