ICBG: "Training, Conservation and Drug Discovery using Panamanian Microorganisms

ICBG：“利用巴拿马微生物进行培训、保护和药物发现

• 批准号: 7685329
• 负责人: William Henry Gerwick
• 金额: $ 62.18万
• 依托单位: SMITHSONIAN INSTITUTION
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-27 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7685329
• 关键词: Address; Agriculture; Agrochemicals; Algae; Area; Bacteria; Biodiversity; Biological; Biological Assay; Biomedical Research; Cancer cell line; Central Nervous System Diseases; Chagas Disease; Collaborations; Collection; Community Outreach; Computers; Contracts; Country; Cyanobacterium; Data; Databases; Developed Countries; Developing Countries; Development; Economics; Equipment and supply inventories; Fostering; Goals; Habitats; High Pressure Liquid Chromatography; Human Resources; Insecta; Institutes; Intellectual Property; Island; Lead; Leishmania; Leishmaniasis; Malaria; Malignant Neoplasms; Marines; Medicine; Methods; Neuraxis; Panama; Panamanian; Participant; Plants; Process; Property Rights; Research; Research Infrastructure; Sampling; Screening procedure; Site; Staging; Structure; Systems Biology; Taxonomy; Techniques; Therapeutic; Training; Transcription Factor AP-2 Alpha; Tropical Disease; Work; base; benefit sharing; cancer therapy; drug discovery; endophytic fungi; fungus; infrastructure development; innovation; microorganism; programs

DESCRIPTION (provided by applicant): DESCRIPTION (provided by applicant): The over-arching goal of this work is to discover new lead compounds from Panamanian microorganisms for the treatment of cancer, CNS disorders, tropical diseases, and agricultural pests, employing a spectrum of innovative as well as traditional bioassays. This pursuit will be inextricably connected to the development of scientific training and capacity building in a biodiversity-rich yet economically-developing country, and will foster tangible results in biodiversity conservation and infrastructure development. The specific aims of this proposal which will allow us to reach these goals are: 1) Use ecological concepts to guide the collection and culture of endophytic fungi, cyanobacteria and other heterotrophic bacteria within the biodiversity-rich country of Panama, 2) Produce extracts of these collected and cultured materials and prefractionate these by appropriate techniques to produce reduced complexity screening units which have active ingredients in increased titer, 3) Through efforts of personnel in AP2 plus our collaborators, to perform biological screens of extracts, prefractionated extracts, and pure compounds in the following therapeutic areas: Cancer, Central Nervous System biology, Agriculture, and Tropical diseases (malaria, leishmania and Chagas' disease), 4) Utilize an integrated approach of taxonomy, computer databases, and LC-MS data to rapidly and efficiently dereplicate known and nuisance compounds at early stages in the discovery process, 5) Isolate active compounds identified in the above assay areas using bioassay-guided approaches, and to characterize these substances using efficient and modern spectroscopic methods, 6) Inventory the biodiversity of terrestrial plants and marine algae in Panama, and to continue to build the permanent floral collections in Panama, 7) Evolve and maintain the formal contracts between all of the participants in this program to address intellectual property rights, promote equitable sharing of benefits, and to facilitate broad access to the data and results of these research endeavors, 8) Help build the scientific infrastructure and expertise necessary to support a sustainable drug discovery program based in Panama, and 9) Integrate our drug discovery and conservation efforts to develop innovative new economic products from the biodiverse marine and terrestrial habitats of Panama. This proposal seeks to discover new medicines from Panama's rich biodiversity of terrestrial and marine microorganisms. The focus of our discovery efforts are new treatments for cancer, CNS disorders, and tropical diseases as well as agricultural chemicals.

描述（由申请人提供）：描述（由申请人提供）：这项工作的整个目标是发现来自巴拿马微生物的新铅化合物，用于治疗癌症，中枢神经系统疾病，热带疾病和农业害虫，以创新的生物体和传统的生物群。这种追求将与生物多样性丰富但经济发展的国家的科学培训和能力建设的发展密不可分，并将促进生物多样性保护和基础设施发展的切实成果。该提案的具体目的将使我们实现这些目标：1）使用生态概念来指导和文化的收集和文化，内生真菌，蓝细菌和其他异育细菌在富裕的巴拿马的富裕国家内，2）在这些材料中产生这些材料和预先培养的精力，从而产生这些材料的提取物，从而产生这些材料，从而产生能力促进这些材料，从而产生能力，从而产生能力，从而产生能力，从而产生能力，从而产生能力，从而产生能力，从而产生一个良好的成分。 AP2中的人员加上我们的合作者，在以下治疗领域中进行提取物，预分离提取物和纯化合物的生物学筛查：癌症，中枢神经系统生物学，农业和农业疾病和热带疾病（疟疾，利什曼尼亚和柴c的疾病）在发现过程的早期阶段的滋扰化合物，5）使用生物测定指导的方法在上述测定区域中鉴定出的活性化合物，并使用高效和现代的光谱方法来表征这些物质，6）清点占领了Panama和Panmane的正式植物的生物多样性，以在Panama和Panmane中建立7份的正式植物，并在PANAMA中保持着7份的持久性，并在PANAMA中保持了7份，并在PANAMA中保持了7份，并在PANAMA中保持了7份的生物多样性。该计划的参与者旨在解决知识产权，促进公平分享利益，并促进广泛访问这些研究工作的数据和结果，8）帮助建立科学基础设施和专业知识，以支持基于巴拿马的可持续药物发现计划，以及9）9）综合我们的药物发现和保护努力，从而融入了我们从事新经济生产的习惯，以开发新的经济习惯。该建议旨在从巴拿马丰富的陆地和海洋微生物生物多样性中发现新药物。我们发现工作的重点是针对癌症，中枢神经系统疾病和热带疾病以及农业化学物质的新疗法。