Renewal: Strategies and Methods for Complex Molecule Synthesis

更新：复杂分子合成的策略和方法

• 批准号: 10623851
• 负责人: Richmond Sarpong
• 金额: $ 42.68万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2027-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10623851
• 关键词: Acceleration; Address; Agriculture; Agrochemicals; Biological Process; Carbon; Chemicals; Complex; Dedications; Disease; Goals; Health; Human; Hydrogen; Inflammation; Malignant Neoplasms; Methodology; Methods; Natural Products; Nitrogen; Organic Synthesis; Pain; Pharmaceutical Preparations; Pharmacologic Substance; Preparation; Skeleton; combat; human disease; improved; novel; novel therapeutics; piperidine; programs; secondary metabolite; skeletal; small molecule

Project Summary/Abstract The goal of this program is to develop new strategies and methods for the synthesis of biologically active secondary metabolites (natural products). A significant portion of our efforts will be dedicated to identifying efficient preparations of these complex molecules. These compounds and their unique derivatives will serve as novel small molecules to combat a range of indications associated with cancer as well as inflammation and pain. Our synthetic studies will lead to new applications of C–H, C–C and C–N bond functionalization methodology in organic synthesis as well as advancing the concept of skeletal editing and its application to the preparation of topologically complex molecules. Finally, working with collaborators, we will gain unique entry into the use of natural products and their derivatives to perturb biological function and ultimately provide promising starting points for new therapeutics.

项目概要/摘要 该计划的目标是开发新的策略和方法来合成 生物活性次生代谢物（天然产物）的很大一部分。 我们的努力将致力于确定这些综合体的有效准备工作 这些化合物及其独特的衍生物将作为新型小分子。 对抗一系列与癌症相关的适应症的分子 我们的合成研究将带来 C-H、C-C 的新应用。 有机合成中的C-N键功能化方法以及进展 骨架编辑的概念及其在拓扑制备中的应用 最后，通过与合作者的合作，我们将获得独特的进入途径。 使用天然产物及其衍生物扰乱生物功能和 最终为新疗法提供有希望的起点。