Strategies and Methods for Complex Molecule Synthesis

复杂分子合成的策略和方法

• 批准号: 10387754
• 负责人: Richmond Sarpong
• 金额: $ 7万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10387754
• 关键词: Address; Agriculture; Award; Biological; Biological Process; Carbon; Collaborations; Complex; Disease; Goals; Health; Human; Inflammation; Lead; Malignant Neoplasms; Methodology; Methods; Molecular; Natural Products; Pain; Pharmaceutical Preparations; Preparation; Pyrones; Reaction; Work; combat; cycloaddition; halogenation; novel; novel therapeutics; programs; small molecule

Summary of Current MIRA Award (R35GM130345) The goal of this program is to develop new strategies and methods for the synthesis of biologically active secondary metabolites (natural products). A significant portion of our efforts is dedicated to identifying efficient preparations of compounds, which, along with their unique derivatives, will serve as novel small molecules to combat a range of indications associated with cancer, inflammation, and pain. Our synthetic studies are focused on C–C bond cleavage methodology, novel enantioselective halogenation and cycloaddition reactions, as well other methods for molecular editing. Our current work also highlights new directions for the use of carvone and pyrone as a sustainable starting material for enantioselective and enantiospecific syntheses. Finally, through collaborations, we will gain unique entry into the use of natural products and their derivatives to perturb biological function and ultimately provide promising starting points for new therapeutics.

当前MIRA奖的摘要（R35GM130345） 该计划的目的是制定合成的新策略和方法 生物活性的二级代谢产物（天然产物）。我们的很大一部分 努力致力于确定化合物的有效制剂，这些化合物以及 它们独特的衍生物将充当新型的小分子，以对抗一系列 与癌症，感染和疼痛相关的适应症。我们的合成研究是 专注于C – C键裂解方法，新型对映选择性卤化和 环加成反应以及分子编辑的其他方法。我们目前的工作 还重点介绍了使用Carvone和Pyrone作为可持续性的新方向 对映选择性和对映体合成的起始材料。最后，通过 合作，我们将获得独特的天然产品及其使用 衍生品的生物学功能，并最终提供有望的起点 用于新疗法。