SPF INDIAN RHESUS MONKEY COLONY FOR AIDS RESEARCH: HIV VACCINE DVMT

SPF 印度恒河猴艾滋病研究群体：HIV 疫苗 DVMT

• 批准号: 7724639
• 负责人: JAMES L BLANCHARD
• 金额: $ 25.29万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7724639
• 关键词: Acquired Immunodeficiency Syndrome; Animals; Artificial Insemination; Assisted Reproductive Techniques; Biological Assay; Computer Retrieval of Information on Scientific Projects Database; Contracts; Female; Funding; Genetic Variation; Grant; HIV vaccine; Housing; Institution; Laboratories; Macaca mulatta; Monitor; Monkeys; Productivity; Research; Research Personnel; Resources; SIV; Screening procedure; Simian Retroviruses; Source; Surface; Testing; Time; United States National Institutes of Health; Validation; Virus; germ free condition; male; pathogen; simian virus; social group; trait

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The specific aim of this application is to establish a colony of Indian rhesus monkeys, free of Simian Immunodeficiency Virus (SIV), simian retrovirus (SRV), herpes b virus, and simian t-lymphotrophic virus (STLV1). This will be accomplished by recruitment of 100 specific pathogen free (SPF) female rhesus monkeys and 15 SPF males in the first year. An additional 50 SPF females and 10 males will be added to the founding colony in each of the subsequent 4 years. We project that by the end of the grant period the colony will have 625 animals. Monkeys will be screened for the presence of the specific pathogens 4 times in the first two years and twice a year after. Social groups will be kept small, 5 to 7 females, and the monkeys will be housed outdoors, in 20ft x 20ft enclosures on natural surfaces. Screening for the presence of the specific pathogens will be done at the Center with validation of assays utilizing commercial labs and NIH funded testing centers. We will incorporate assisted reproductive techniques such as artificial insemination to maximize the productivity of the colony. In addition, we have contracted with established laboratories to genetically monitor the colony for genetic diversity and to identify specific traits that are currently valuable in AIDS research.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该应用的具体目的是建立一个印度恒河猴的菌落，该猴子不含邻氨酸免疫缺陷病毒（SIV），猿猴逆转录病毒（SRV），疱疹病毒和猿猴T-淋巴营养性病毒（STLV1）。这将通过在第一年招募100个特定病原体（SPF）雌性恒河猴和15位SPF雄性来实现。在随后的4年中，将增加50名SPF女性和10名男性。我们预测，到赠款期结束时，殖民地将有625只动物。猴子将在头两年且一年后两次筛查特定病原体的存在4次。社会群体将保持小5至7名女性，猴子将在户外安置在20英尺x 20英尺的自然表面上。筛查特定病原体的存在将在中心进行，并使用商业实验室和NIH资助的测试中心进行验证。我们将结合辅助生殖技术，例如人工授精，以最大化菌落的生产力。此外，我们还与已建立的实验室签约，以基因监测遗传多样性的菌落，并确定目前在艾滋病研究中有价值的特定特征。