Husbandry and Management Core

畜牧与管理核心

• 批准号: 10373933
• 负责人: Kamm Prongay
• 金额: $ 14.75万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10373933
• 关键词: AIDS-Related Opportunistic Infections; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adult; Animal Model; Animals; Anti-Retroviral Agents; Artificial Insemination; Behavioral; Breeding; Development; Disease; Disease Surveillance; Female; Functional disorder; Genetic Variation; Goals; Grant; HIV; HIV Infections; HIV vaccine; Health; Herpesvirus 1; Immune response; Infant; Infection; Macaca mulatta; Modeling; Monitor; Mycobacterium tuberculosis; Outcome; Pathogenesis; Persons; Pharmaceutical Preparations; Practice Management; Preventive care; Research; Resources; Risk; SIV; Serology test; Simian Retroviruses; Target Populations; Therapy Evaluation; Vaccine Research; Vaccines; Virus; Weight maintenance regimen; Zoonoses; animal breeding; antiretroviral therapy; base; clinical care; enzootic; fight against; germ free condition; innovation; nonhuman primate; preservation; programs; psychologic; screening; social

PROJECT SUMMARY, Core A: Husbandry and Management Core The U42 SPF 4 Rhesus macaque breeding colony for AIDS research produces MHC class-1 typed rhesus macaques (Macaca mulatta) who are negative to simian immunodeficiency virus (SIV), simian T-lymphotropic virus (STLV-1), simian retrovirus (type D restrovirus or SRV), and macacine herpesvirus-1 (BV). SPF4 Indian origin rhesus macaques are the premier animal model for HIV/AIDS research, including studies of HIV pathogenesis, AIDS-related opportunistic infections, and the development of HIV treatments and vaccines. Demand for this resource continues to grow, and is projected to increase over the grant cycle. A predictable supply of disease-free, genetically characterized nonhuman primates is critical in the fight against HIV/AIDs. The overall aim of the Husbandry and Management Core is to maintain the ONPRC Specific Pathogen Free (SPF) rhesus macaque breeding colony for AIDS research at a targeted population of 175 adult breeder females capable of producing at least 120 surplus animals annually for research use. To achieve this we will provide innovative team based management practices including new social monitoring strategies, a weight management program for at-risk infants, serologic assays for Mycobacterium tuberculosis screening, and introduction of an artificial insemination program to expand genetic diversity.

项目摘要，核心A：饲养和管理核心 艾滋病研究的U42 SPF 4恒河猕猴育种菌落产生MHC Class-1键入恒河猴 猕猴（Macaca mulatta），抗邻肌免疫缺陷病毒（SIV），猿猴T-淋巴细胞体 病毒（STLV-1），猿猴逆转录病毒（D型约束病毒或SRV）和大氨酸疱疹病毒-1（BV）。 SPF4印度 起源恒河猕猴是艾滋病毒/艾滋病研究的主要动物模型，包括艾滋病毒的研究 发病机理，与艾滋病相关的机会感染以及艾滋病毒治疗和疫苗的发展。 对该资源的需求不断增长，预计将在整个赠款周期中增加。可预测的 无疾病，遗传特征的非人类灵长类动物的供应对于与艾滋病毒/艾滋病的斗争至关重要。 饲养和管理核心的总体目的是维持无ONPRC特定病原体 （SPF）在175个成年育种者的目标人群中，用于艾滋病研究的恒河猴猕猴育种菌落 能够每年至少生产120种剩余动物的女性进行研究。为了实现这一目标，我们将 提供创新的团队管理实践，包括新的社会监控策略，重量 高危婴儿的管理计划，结核分枝杆菌筛查的血清学测定和 引入人工授精计划以扩大遗传多样性。