MAINTAINANCE OF AN SPF MACAQUE BREEDING COLONY FOR AIDS RESEARCH: AIDS

维持 SPF 猕猴繁殖群以进行艾滋病研究：艾滋病

• 批准号: 8356919
• 负责人: JAMES L BLANCHARD
• 金额: $ 100.36万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8356919
• 关键词: Acquired Immunodeficiency Syndrome; Animals; Award; Breeding; Country; Funding; Goals; Grant; Income; Infant; Macaca; Macaca mulatta; Monitor; Monkeys; National Center for Research Resources; Primates; Principal Investigator; Process; Production; Protocols documentation; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Sales; Source; Specific Pathogen Frees; United States National Institutes of Health; Viral; cost; germ free condition; meetings; programs; success

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): Tulane National Primate Center (TNPRC) has one of the largest rhesus monkey breeding colonies in the US. This resource has provided animals for NIH funded research projects for several decades and is a critical component of the Center's successful research program. Because over half of all projects at TNPRC are initiated by outside investigators, this resource is also essential to the success of many NIH-funded investigators throughout the country. Several years ago TNPRC established the goal of having only specific pathogen free (SPF) monkeys at the Center. A major step toward that goal was the award of this U42 grant in 2001 to provide funds to establish an SPF Indian-origin rhesus monkey colony at TNPRC to provide monkeys for NIH-funded AIDS research. Approximately 800 animals were recruited into the U42 funded SPF colony in the first four years. The colony is expected to increase in number to 1,000 animals by the end of the last year of the current grant, meeting the goal of the original application. The objective of this application is to request funds to support an average of 900 SPF rhesus monkeys and to continue to monitor the viral status of the colony for the next 5 years. The plan is to maintain the colony at a level that will allow production of at least 300 infants each year. This will provide at least 150 animals for assignment to NIH-funded AIDS research protocols and 150 for replacement breeders. Beginning in year 2, revenue from animal sales will be returned to the grant as program income. This will begin the process of transition to a self-sustaining colony, which will be achieved by the end of the grant period.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 描述（由申请人提供）：杜兰国家灵长类动物中心（TNPRC）是美国最大的恒河猴繁殖殖民地之一。该资源为NIH资助的研究项目提供了数十年的动物，并且是该中心成功研究计划的关键组成部分。由于TNPRC的所有项目中有一半以上是由外部调查人员启动的，因此该资源对于全国许多NIH资助的研究人员的成功也至关重要。几年前，TNPRC确定了仅在中心拥有特定病原体（SPF）猴子的目标。朝着该目标迈出的主要一步是在2001年获得这项U42赠款，旨在提供资金，以在TNPRC建立一个SPF印度 - 印度恒河猴猴子殖民地，为NIH资助的艾滋病研究提供猴子。在头四年中，将大约800只动物招募到U42资助的SPF菌落中。预计到当前赠款的最后一年结束时，该殖民地将增加到1,000只动物，达到了原始申请的目标。本申请的目的是要求资金平均支持900个SPF恒河猴，并继续监测未来5年殖民地的病毒状况。该计划是将殖民地保持在每年至少生产300名婴儿的水平。这将至少提供150只动物，用于分配NIH资助的艾滋病研究方案，150种用于替代育种者。从第二年开始，动物销售的收入将退还给赠款作为计划收入。这将开始过渡到自我维持的殖民地的过程，这将在赠款期结束之前实现。