Emory/Georgia TB Research Advancement Center (TRAC)

埃默里/佐治亚州结核病研究促进中心 (TRAC)

• 批准号: 10596180
• 负责人: Cheryl Liane Day
• 金额: $ 20.07万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-23 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10596180
• 关键词: Acquired Immunodeficiency Syndrome; Address; Animal Model; Animals; Archives; Area; Award; Basic Science; Biological; Biological Assay; Cell Culture Techniques; Cells; Cessation of life; Clinical; Collaborations; Consultations; Control Animal; Data; Data Analyses; Databases; Development; Disease; Doctor of Philosophy; Electronics; Environment; Experimental Designs; Extramural Activities; Faculty; Flow Cytometry; Foundations; Funding; Goals; HIV; HIV/TB; Health; Human; Immunity; Immunologics; Immunology; In Vitro; Infection; Institution; Knowledge; Laboratories; Lead; Leadership; Link; Methods; Microbiology; Mission; Modeling; Mycobacterium Infections; Mycobacterium tuberculosis; Pathogenesis; Primates; Research; Research Personnel; Resources; Rodent; SIV; Series; Services; Sorting; Specimen; Surveys; Talents; Training; Translational Research; Tuberculosis; Universities; Vaccination; Vaccines; Veterinary Medicine; assay development; biobank; co-infection; cohort; college; combat; community center; high dimensionality; human model; innovation; instrument; laboratory equipment; member; multidisciplinary; mycobacterial; nonhuman primate; novel strategies; pandemic disease; programs; protocol development; repository; tool; transmission process; tuberculosis immunity; vaccination against tuberculosis; vaccine trial

The Basic & Translational Science (Basic Science) Core of the Emory/Georgia TRAC will provide expertise and resources to facilitate TRAC investigator-led studies of mycobacterial pathogenesis, transmission, and host immunity in both human and animal models of Mycobacterium tuberculosis (Mtb) infection. The Basic Science Core will capitalize on a unique set of resources available to the TRAC community, including the Yerkes National Primate Research Center with capacity to conduct Mtb studies in rodents and nonhuman primates, and the University of Georgia Animal Health Research Center with extensive animal BSL3 lab space and capacity to conduct mycobacterial infection and vaccination studies in a variety of large, medium, and small animals. The overall mission of the Basic Science Core is to provide laboratory expertise, training, and resources to catalyze opportunities for innovative multidisciplinary and highly collaborative TB research programs engaging Basic Science Core faculty, early-stage investigators, and established investigators who are new to the TB field. The Core will achieve these goals by providing training, consultation, and services with state-of-the-art laboratory equipment, facilities, and methods, including the newest immunological and microbiological assays and animal Mtb infection models, in addition to providing a quality-controlled central repository of materials for the TRAC community. In Aim 1, consultation in experimental design and laboratory assay approaches will be provided to investigators who are planning basic and translational science studies of Mtb. Specific training areas will include Mtb culture and in vitro infection; Mtb infection of animals; and lab assay training, data interpretation, and protocol development. In Aim 2, the Core will provide support to TRAC investigators to generate preliminary laboratory-based data for internal and external funding applications; conduct laboratory assays and animal Mtb infection and vaccination studies in support of TRAC-series Developmental awards and other funded projects; and support the development of new microbiology and immunology laboratory-based assays. In Aim 3, a biorepository and electronic database will be established for archiving clinical specimens and isolates from human cohorts across a range of Mtb infection and disease states; specimens from Mtb-infected and control animals; and common Mtb laboratory strains for use by TRAC investigators. In summary, the Basic Science Core will provide value-added activities in training, services, and materials to Emory/Georgia TRAC investigators, with the overall goal of supporting TRAC investigators to successfully establish and expand innovative research programs filling critical knowledge gaps in TB pathogenesis, transmission, and immunity to more effectively combat the global TB pandemic.

Emory/Georgia Trac的基础与翻译科学（基础科学）将提供专业知识 和资源以促进TRAC研究者主导的分枝杆菌发病机理，传播和 结核分枝杆菌（MTB）感染的人类和动物模型中的宿主免疫。基本 科学核心将利用TRAC社区可用的独特资源，包括 Yerkes国家灵长类动物研究中心具有在啮齿动物和非人类中进行MTB研究的能力 灵长类动物和佐治亚大学动物健康研究中心具有广泛的动物BSL3实验室空间 以及在各种大型，中和 小动物。基础科学核心的总体使命是提供实验室专业知识，培训和 为创新的多学科和高度协作的结核病研究催化机会的资源 与基础科学核心教师，早期调查人员和成熟的调查员有关的计划 是结核病领域的新手。核心将通过提供培训，咨询和服务来实现这些目标 最先进的实验室设备，设施和方法，包括最新的免疫学和 微生物学测定和动物MTB感染模型，除了提供质量控制的中央 TRAC社区的材料存储库。在AIM 1中，在实验设计和实验室进行咨询 测定方法将提供给正在计划基础和转化科学研究的调查人员 MTB。特定的培训领域将包括MTB培养和体外感染； MTB感染动物；和实验室 测定培训，数据解释和协议开发。在AIM 2中，核心将为TRAC提供支持 研究人员为内部和外部资助应用程序生成初步的实验室数据； 进行实验室测定和动物MTB感染和疫苗接种研究，以支持Trac系列 发展奖和其他资助的项目；并支持新的微生物学和 免疫学实验室测定法。在AIM 3中，将建立一个生物座和电子数据库 归档临床标本和来自人类人群中MTB感染和疾病的分离株 国家来自MTB感染和控制动物的标本；和常见的MTB实验室应变供TRAC使用 调查人员。总而言之，基础科学核心将在培训，服务和 Emory/Georgia Trac调查人员的材料，其总体目标是支持TRAC研究人员 成功建立和扩展创新的研究计划，以填补结核病的关键知识差距 发病机理，传播和免疫力更有效地打击全球结核大流行。