Absolute Measurement of Cerebral Blood Flow Using Diffuse Optics

使用漫射光学器件绝对测量脑血流量

• 批准号: 7477238
• 负责人: Turgut Durduran
• 金额: $ 22.36万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7477238
• 关键词: Acetazolamide; Address; Adult; Agreement; Algorithms; Area; Arteries; Beds; Biological; Blood; Brain; Breathing; Caffeine; Calibration; Carbon Dioxide; Cations; Central Nervous System Diseases; Cerebrovascular Circulation; Cerebrum; Classification; Clinical; Clinical Management; Clinical Research; Clinical Trials; Complex; Computer Simulation; Computer software; Condition; Congenital Heart Defects; Contrast Media; Craniocerebral Trauma; Data; Development; Diagnostic; Diffuse; Diffusion; Disease; Disease Management; Doppler Ultrasound; Equation; Generic Drugs; Goals; Head; Hemoglobin; Hemorrhage; Heterogeneity; Human; Individual; Intake; Intensive Care; Intervention; Invasive; Libraries; Localized; MRI Scans; Magnetic Resonance Imaging; Measurement; Measures; Medical; Methods; Modality; Modeling; Near-Infrared Spectroscopy; Neuraxis; Numbers; Optics; Organ; Patients; Photons; Physiological; Positron-Emission Tomography; Procedures; Property; Range; Recruitment Activity; Regulation; Relative (related person); Reproducibility; Research; Scheme; Side; Signal Transduction; Simulate; Source; Spectrum Analysis; Spin Labels; Standards of Weights and Measures; Stroke; Techniques; Technology; Testing; Time; Tissues; Training; Urination; Xenon; acute stroke; base; clinical application; cohort; day; design; design and construction; detector; experience; improved; in vivo; instrument; instrumentation; man; neonate; programs; research study; tissue phantom; tool

DESCRIPTION (provided by applicant): Clinical interventions in central nervous system (CNS) disease management base decisions on primarily deductions from a variety of secondary information and on the individual or collective experience of clinicians rather than direct measurements of brain function, and in particular cerebral blood flow (CBF). A non-invasive, continuous, bed-side instrument for measurement of CBF in the micro-vasculature would, in fact, be highly desirable for management of a variety of CNS disorders such as stroke, hemorrhage, and head trauma. Diagnostics in current use have limitations. For example, available modalities deliver either insufficient information (e.g. transcranial Doppler Ultrasound measurement of velocity within selected arteries) or are relatively inaccessible (Xenon inhalation CT, arterial spin labeling MRI, PET). The premise of this proposal is that a newly developed optical technique can be used to measure absolute CBF. Diffuse correlation spectroscopy (DCS) offers new, non-invasive medical diagnostic tools whose capabilities for relative measurements have recently been demonstrated in functional activation studies of intact human brain. Further developments in DCS are expected to have a clinical impact. To that end, this proposal addresses the shortcomings of DCS in a systematic way. Questions such as; ``What is the biological origin of the signal?'', ``Which tissue volume is being probed?'' and ``Can the absolute, cortical CBF be estimated?'' are addressed via computer simulations, experiments on tissue simulating phantoms and via in vivo studies. If successful, pilot clinical trials and further development of the instrumentation will follow. We expect that in a short time period, the clinical utility of this technology will be established. Another side-benefit of this project will be that other clinical applications in other diseases and organs will be feasible. Clinical interventions in central nervous system (CNS) disease management base decisions on primarily deductions from a variety of secondary information and experience of clinicians rather than direct measurements of cerebral blood flow (CBF). A non-invasive, continuous, bed-side instrument for measurement of CBF in the micro-vasculature would be highly desirable for management of a variety of CNS disorders such as stroke, hemorrhage, and head trauma. The proposed optical technique will take a big step towards fullfiling this void.

描述（由申请人提供）：中枢神经系统（CNS）疾病管理的临床干预措施主要从各种二次信息以及临床医生的个体或集体经验中扣除，而不是直接测量大脑功能，尤其是脑血流（CBF）。实际上，一种用于测量CBF的无创，连续的床位仪器实际上是高度可取的，可用于管理各种中枢神经系统疾病，例如中风，出血和头部创伤。当前使用中的诊断有局限性。例如，可用的模态提供不足的信息（例如，所选动脉内速度的经颅多普勒超声测量）或相对无法访问（Xenon吸入CT，动脉自旋标记MRI，PET，PET）。该提案的前提是一种新开发的光学技术可用于测量绝对CBF。弥漫性相关光谱（DC）提供了新的非侵入性医学诊断工具，这些工具最近在完整的人脑的功能激活研究中证明了相对测量的能力。 DC的进一步发展有望产生临床影响。为此，该提案以系统的方式解决了DC的缺点。诸如； ``信号的生物学起源是什么？''，``正在探测哪些组织体积？''和``可以通过计算机模拟，模拟幻象和通过Vivo研究进行实验来解决绝对的皮质CBF？''。如果成功，将随后进行试验临床试验和进一步的仪器开发。我们预计将在短时间内建立该技术的临床实用性。该项目的另一个副效力将是其他疾病和器官中的其他临床应用是可行的。中枢神经系统（CNS）疾病管理基础决定的临床干预措施主要是从临床医生的各种二级信息和经验中扣除的决定，而不是直接测量大脑血流（CBF）。用于测量微脉管系统中CBF的无创，连续的床位仪器对于管理各种CNS疾病（例如中风，出血和头部创伤）非常需要。提出的光学技术将迈出重大空白的一步。