STUDIES OF CUSHING'S DISEASE

库欣病的研究

• 批准号: 7604780
• 负责人: ROY E WEISS
• 金额: $ 1.07万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604780
• 关键词: Adrenal Gland Hyperfunction; Computer Retrieval of Information on Scientific Projects Database; Condition; Corticotropin; Cushing Syndrome; Dexamethasone; Diagnosis; Etiology; Funding; Glucocorticoids; Grant; Hour; Hydrocortisone; Institution; Methods; Obesity; Pituitary-dependent Cushing' s disease; Plasma; Research; Research Personnel; Resources; Salivary; Serum; Sleep; Sleep Apnea Syndromes; Source; Testing; United States National Institutes of Health; improved; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Determination of the underlying etiology of hypercortisolism is extremely challenging due to the nonspecificity of available tests. Consequently, the treatment currently offered for this highly morbid condition is unsuccessful in 20-25% of subjects. We propose that analysis of the 24 hour secretory profile of salivary cortisol, serum cortisol, and plasma ACTH will provide sensitive markers for the correct diagnosis of the etiology of hypercortisolism. In addition, sleep-disordered breathing (SDB) is common in subjects with Cushing s syndrome. It is unclear whether the SDB results from the associated obesity or whether there is a direct effect of the glucocorticoids on sleep centers. We hypothesize that (1) the use of salivary cortisol 24 hour profile as well as salivary response to CRF stimulation with or without dexamethasone is an accurate method of diagnosing Cushing s syndrome and (2) the correction of the hypercortisolism will improve the SDB seen in Cushing s syndrome.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 由于现有测试的非特异性，确定皮质醇增多症的根本病因极具挑战性。因此，目前针对这种高度发病性疾病的治疗对 20-25% 的受试者来说是不成功的。 我们建议，对唾液皮质醇、血清皮质醇和血浆 ACTH 的 24 小时分泌谱进行分析，将为正确诊断皮质醇增多症的病因提供敏感标记。此外，睡眠呼吸障碍（SDB）在库欣综合征患者中很常见。 目前尚不清楚 SDB 是否由相关肥胖引起，或者糖皮质激素是否对睡眠中枢有直接影响。 我们假设 (1) 使用唾液皮质醇 24 小时曲线以及唾液对 CRF 刺激（有或没有地塞米松）的反应是诊断库欣综合征的准确方法，(2) 纠正皮质醇增多症将改善在库欣综合征。