ESTABLISHMENT OF A SPF RHESUS MACAQUE COLONY

SPF 恒河猴群体的建立

• 批准号: 8172641
• 负责人: Larry Bill Cummins
• 金额: $ 47.65万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172641
• 关键词: Air; Animals; Award; Cercopithecine Herpesvirus 1; Computer Retrieval of Information on Scientific Projects Database; Funding; Goals; Grant; Harvest; Housing; Institution; Macaca mulatta; Primates; Production; Research; Research Personnel; Resources; SIV; Schedule; Simian T-lymphotropic virus 1; Source; Specific Pathogen Frees; United States; United States National Institutes of Health; base; germ free condition

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this project is to increase the nation's capacity to produce Indian-origin rhesus monkeys (Macaca mulatta) that are specific pathogen-free (SPF) for herpes B virus, SIV, SRV, and STLV-1. The colony will continue to produce high quality genetically characterized animals for use I AIDS-related research by NIH grantees based at the Southwest National Primate Research Center (SNPRC) and at other research institutions in the southwestern region of the United States. Most of the founding stock of the SNPRC colony was obtained through acquisition of an existing SPF colony from the U.S. Air Force (USAF) to the Primate Center. A C06 grant (RR-01-130, SPF Rhesus Macaque Facility for SNPRC) was awarded to the SNPRC for the construction of new housing. The proposed production and acquisition schedule will result in increasing the colony size to achieve a steady state of 430 animals. This target colony size will allow an annual harvesting of 70 animals per year beginning in Year 06 to fulfill critical needs in AIDS-related research and research needs of the USAF.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该项目的目标是提高国家生产印度原产恒河猴（Macaca mulatta）的能力，这些恒河猴对 B 型疱疹病毒、SIV、SRV 和 STLV-1 无特定病原体 (SPF)。 该群体将继续生产高质量的基因特征动物，供美国国立卫生研究院西南国家灵长类动物研究中心 (SNPRC) 和美国西南部地区其他研究机构的受资助者进行艾滋病相关研究。 SNPRC 群体的大部分创始种群是通过从美国空军 (USAF) 向灵长类动物中心收购现有的 SPF 群体而获得的。 SNPRC 获得了 C06 拨款（RR-01-130，SNPRC SPF 恒河猴设施），用于建造新住房。 拟议的生产和收购计划将导致群体规模增加，以达到 430 只动物的稳定状态。 从 06 年开始，这一目标群体规模将允许每年收获 70 只动物，以满足艾滋病相关研究和美国空军的研究需求。