Ventilated Rodent Caging for the University of Delaware Life Science Research Facility

特拉华大学生命科学研究设施的通风啮齿动物笼舍

• 批准号: 10730651
• 负责人: Gwen Talham
• 金额: $ 33.95万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2024-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10730651
• 关键词: Air; Allergens; Alzheimer' s Disease; Ammonia; Animal Experimentation; Animal Housing; Animal Model; Animals; Area; Asthma; Award; Biological Sciences; Biology; Biomedical Engineering; Biomedical Research; Brain imaging; Cardiovascular Diseases; Caring; Centers of Research Excellence; Circulation; Core Facility; Delaware; Development; Disease; Equipment; Eye diseases; Faculty; Fire - disasters; Funding; Future; Genes; Grant; Growth; Health; House mice; Housing; Human Resources; Hypersensitivity; Institution; Joints; Language Disorders; Mus; Musculoskeletal; Musculoskeletal Diseases; Neurologic; Neurosciences; Neurosciences Research; Personal Satisfaction; Physics; Principal Investigator; Psychology; Rattus; Reproducibility; Research; Research Project Grants; Risk; Rodent; Secure; Source; Speech Disorders; Stress; System; Therapeutic; United States National Institutes of Health; Universities; Urine; biomedical imaging; cardiovascular health; cost; faculty support; improved; novel therapeutics; pathogen exposure; prairie vole; prevent; programs; research facility; research study; square foot; ventilation

Abstract/Project Summary The Life Science Research Facility (LSRF) at the University of Delaware is a 29,000 sq ft vivarium, which houses mice, rats and prairie voles. This facility currently supports the biomedical research of 31 different Principal Investigators (PIs) and is a core facility for the NIH-funded IdeA Network of Biomedical Research Excellence (INBRE). Two partner institutions in INBRE, Delaware State University and Christiana Care Gene Editing Institute, also house animals in the LSRF. Most recently the COBRE-funded Delaware Center for Musculoskeletal Research was established in 2021, and the Center has an animal model core incorporated within the LSRF. PIs that have used the facility since 2020 have secured a total of $50M in research awards (total award dollars, all sources) including a $13M NIH Center for Biomedical Research Excellence (COBRE), $5M State of Delaware match to INBRE, etc. There have been significant increases in faculty hiring at the University over the last decade, including strategic efforts to grow in areas that leverage the LSRF. Areas include biomedical engineering, biological sciences, speech and language disorders, and neuroscience. The average numbers of mice and prairie voles housed in the facility has increased by approximately 62% over the last 5 years. It is projected that this growth will continue, and the current rodent housing is nearing capacity. This grant request is for additional ventilated rodent caging to increase the rodent housing capacity of the LSRF so that lack of rodent housing space will not negatively impact the growing research programs of the University of Delaware. Not only will the proposed expansion of ventilated rodent caging make more efficient use of space than the older microisolator caging, it will improve the health and well-being of the animals. Ventilated caging improves rodent health and research reproducibility by decreasing the exposure of animals to ammonia derived from urine due to increased air circulation and decreases the risk of the animals to pathogen exposure as the air is HEPA purified. Ventilated caging also decreases animal stress (and risk of such stress confounding research results) as animals are handled less because cages need less frequent changing. As a byproduct, this decreases exposure of personnel to allergens and decreases operational costs as more animals can be cared for by each animal caretaker.

摘要/项目摘要 特拉华大学的生命科学研究设施（LSRF）是29,000平方英尺的Vivarium， 房屋老鼠，老鼠和草原田鼠。该设施目前支持31种不同的生物医学研究 首席研究人员（PIS），是NIH资助的生物医学研究思想网络的核心设施 卓越（ybre）。 inbre，特拉华州立大学和克里斯蒂安娜护理基因的两个合作伙伴机构 编辑学院，也是LSRF的动物。最近是毛茸茸资助的特拉华州中心 肌肉骨骼研究成立于2021年，该中心具有动物模型核心融合 在LSRF中。自2020年以来使用该设施的PI已获得了5000万美元的研究奖 （奖励总计，所有来源），包括1300万美元的NIH生物医学研究中心（Cobre）， 500万美元的特拉华州与inbre等等。等等。 在过去的十年中，大学，包括在利用LSRF的领域发展的战略努力。区域 包括生物医学工程，生物科学，言语和语言障碍以及神经科学。这 该设施中容纳的小鼠和草原田鼠的平均数量比该设施增加了约62％ 最近5年。预计这种增长将继续，目前的啮齿动物住房接近能力。 该赠款请求是额外的通风啮齿动物笼，以提高啮齿动物的住房能力 LSRF因此缺乏啮齿动物住房空间不会对不断增长的研究计划产生负面影响 特拉华大学。拟议的通风啮齿动物笼的膨胀不仅会提高效率 使用空间比较旧的微型固定笼，它将改善动物的健康和福祉。 通风笼可以通过减少动物的暴露来改善啮齿动物的健康和研究的可重复性 由于空气循环增加而衍生出尿液的氨，并降低了动物的风险 病原体暴露在空气中被HEPA纯化。通风笼还减轻了动物的压力（以及 这种压力混淆的研究结果）由于笼子所需的频率较低，因此动物的处理较少 更改。作为副产品，这减少了人员接触过敏原并降低了操作成本 因为每个动物看守可以照顾更多动物。