THE ROLE OF CORTISOL IN GESTATIONAL DIABETES MELLITUS

皮质醇在妊娠糖尿病中的作用

• 批准号: 7378636
• 负责人: ROY E WEISS
• 金额: $ 0.63万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-18 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378636
• 关键词: cortisol; gestational diabetes mellitus; glucose tolerance; hypercortisolism; insulin sensitivity /resistance; role; secretion; tissues

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pregnant Women with gestational diabetes mellitus (GDM) will have an attenuation in their hypothalamic-pituitary-adrenal (H-P-A) axis which results in elevated total and free morning cortisol levels, discrete elevations in cortisol secretion throughout the day, and altered tissue response to cortisol. It is hypothesized that this functional hypercortisolism contributes to the increased insulin resistance seen in pregnant women with GDM versus normal glucose tolerance pregnant women.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。患有妊娠糖尿病 (GDM) 的孕妇的下丘脑 - 垂体 - 肾上腺 (H-P-A) 轴会减弱，导致早晨总皮质醇和游离皮质醇水平升高，全天皮质醇分泌离散升高，并改变组织对皮质醇的反应。据推测，与糖耐量正常的孕妇相比，这种功能性皮质醇增多症会导致 GDM 孕妇的胰岛素抵抗增加。