ESTABLISHMENT AND EXPANSION OF A SPF RHESUS COLONY: AIDS, GENOME

SPF 恒河猴群体的建立和扩展：艾滋病、基因组

• 批准号: 8173357
• 负责人: RUDOLF Paul BOHM
• 金额: $ 41.18万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173357
• 关键词: Acquired Immunodeficiency Syndrome; Address; Animals; Behavioral; Breeding; Censuses; Computer Retrieval of Information on Scientific Projects Database; Disease; Funding; Future; Gastrointestinal Agents; Gastrointestinal Diseases; Genetic Variation; Genome; Grant; Institution; Investigation; Macaca mulatta; Morbidity - disease rate; Opportunistic Infections; Population; Prevention; Primates; Production; Research; Research Personnel; Research Project Grants; Resources; Role; Screening procedure; Source; Specific Pathogen Frees; United States National Institutes of Health; Viral; biomedical resource; gene therapy; germ free condition; meetings; mortality; offspring; programs; social group; treatment strategy; vaccine development

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): Over the past five years the Tulane National Primate Research Center (TNPRC) has successfully developed and expanded its specific pathogen free (SPF) rhesus monkey breeding colony. By the end of the current funding period the U24 SPF colony will have grown from a population of zero animals in Year 1 to greater than 1000 animals at the end of Year 5. The colony was completely derived from the TNPRC conventional colony and has matured to the point that production over the next five years will create a self sustaining population allowing assignment of approximately 150 animals per year to NIH funded AIDS research programs. The entire TNPRC SPF colony supported by U24 and U42 grants is the largest in the NCRR/OAR funded program comprising 36 percent of the total animals reflected in the current program census. Over half of the animal allocations from the TNPRC SPF colony over the past five years have been to affiliate (outside) investigators demonstrating our commitment as a national biomedical resource. The further characterization and expansion of the SPF colony proposed in this application will be accomplished using several strategies. Funds have been requested to provide support for the founder SPF breeding stock and their offspring until assignment to AIDS research projects occurs. Funds for viral screening of animals have been requested. The expanded SPF9 (super clean) colony will continue to be grown to meet the needs of specialized AIDS studies including gene therapy, vaccine development and the investigation of opportunistic infections. Because gastrointestinal disease is the leading cause of morbidity and mortality in the TNPRC SPF breeding colonies, we plan to screen animals for selected gastrointestinal agents to further clarify their roles in disease and develop prevention and possible treatment strategies. Behavioral studies will be performed to address specific issues related to the formation of social groups of unrelated animals which has been required to maintain genetic diversity and maintain SPF status. For the colony that is supported by this grant, it is anticipated that 1000 rhesus monkeys will be maintained into the future. The size of the entire TNPRC SPF colony (support from all sources) will be over 3200 animals. Continued support of the TNPRC SPF colony will assist in alleviating the critical national shortage of well characterized rhesus monkeys for the AIDS research effort.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 描述（由申请人提供）：在过去的五年中，杜兰国家灵长类动物研究中心（TNPRC）已成功开发并扩展了其特定的无病原体（SPF）恒河猴猴育种殖民地。到当前资金期结束时，U24 SPF菌落将从1年级的零动物种群中发展到第5年底的1000多种动物。该殖民地完全源自TNPRC的传统殖民地，并已成熟，并已成熟到未来五年的生产将创造自我维持的人口，从而使每年的150个动物分配了大约150个动物的NIH AIDS AIDS AIDS AIDS AIDS AIDS AIDS AIDS AIDS AIDS AIDS分配。 U24和U42赠款支持的整个TNPRC SPF菌落是NCRR/OAR资助的计划中最大的TNPRC SPF菌落，占当前计划人口普查中反映的动物的36％。在过去五年中，TNPRC SPF殖民地的动物分配中有一半以上是分支机构（外部）调查人员证明了我们作为国家生物医学资源的承诺。 本应用程序中提出的SPF菌落的进一步表征和扩展将使用多种策略来实现。已要求资金为创始人的SPF育种股票及其后代提供支持，直到发生艾滋病研究项目为止。已要求进行病毒筛查的资金。扩大的SPF9（超级清洁）菌落将继续种植，以满足特殊艾滋病研究的需求，包括基因疗法，疫苗开发和机会性感染的研究。由于胃肠道疾病是TNPRC SPF繁殖菌落中发病率和死亡率的主要原因，因此我们计划筛选动物作为选定的胃肠道剂，以进一步阐明其在疾病中的作用，并制定预防和可能的治疗策略。将进行行为研究，以解决与保持遗传多样性并维持SPF状态所必需的与社会群体形成有关的特定问题。 对于这笔赠款支持的殖民地，预计将维持1000只恒河猴。整个TNPRC SPF菌落（所有来源的支持）的大小将超过3200只动物。 TNPRC SPF殖民地的持续支持将有助于减轻全国范围内对艾滋病研究工作的恒河猴的严重短缺。