ESTABLISHMENT OF SPECIFIC PATHOGEN FREE RHESUS AND PIGTA: AIDS GENOME

无特定病原体的恒河猴和 PIGTA 的建立：艾滋病基因组

• 批准号: 8173373
• 负责人: Michael K Axthelm
• 金额: $ 13.34万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173373
• 关键词: AIDS Vaccines; AIDS-Related Opportunistic Infections; Animal Model; Breeding; Computer Retrieval of Information on Scientific Projects Database; Development; Disease; Environment; Funding; Future; Genetic; Genome; Grant; Housing; Human Virus; Immunocompromised Host; Institution; Lentivirus Infections; Macaca; Macaca mulatta; Pathogenesis; Research; Research Personnel; Resources; Source; Specific Pathogen Frees; United States National Institutes of Health; Viral; germ free condition; meetings; programs; AIDS Vaccines; AIDS-Related Opportunistic Infections; Animal Model; Breeding; Computer Retrieval of Information on Scientific Projects Database; Development; Disease; Environment; Funding; Future; Genetic; Genome; Grant; Housing; Human Virus; Immunocompromised Host; Institution; Lentivirus Infections; Macaca; Macaca mulatta; Pathogenesis; Research; Research Personnel; Resources; Source; Specific Pathogen Frees; United States National Institutes of Health; Viral; germ free condition; meetings; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (Provided by applicant): Opportunistic human viruses and their simian counterparts are similar in their genetic makeup and induce a similar spectrum of diseases in their immunosuppressed hosts. Experimental lentivirus infections in rhesus macaques are wildly recognized as the most import animal model for AIDS-related research and there is an urgent need to expand breeding programs to meet future AIDS vaccine and pathogenesis research program needs. Development of an Indian rhesus macaque breeding colony free of opportunistic viral agents is proposed to enhance the usefulness of this unique resource for studies focused on AIDS-related opportunistic infections. Housing space is proposed to provide a protected environment for this unique Expanded Specific Pathogen Free (ESPF) macaque resource and to facilitate enhanced macaque breeding efforts.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 描述（由申请人提供）：机会主义的人类病毒及其基因组成相似，并在其免疫抑制宿主中引起类似的疾病范围。 恒河猕猴中的实验性慢病毒感染被广泛认为是与艾滋病相关研究的最进口动物模型，并且迫切需要扩大育种计划，以满足未来的艾滋病疫苗和发病机理研究计划的需求。 提出了不含机会性病毒剂的印度恒河猕猴育种菌落的发展，以增强这种独特的资源对侧重于与艾滋病相关的机会性感染的研究的实用性。 提议住房空间为这种独特的扩展特定病原体（ESPF）猕猴资源提供受保护的环境，并促进增强的猕猴育种工作。