ESTABLISHMENT OF SPECIFIC PATHOGEN FREE RHESUS AND PIGTA: AIDS GENOME

无特定病原体的恒河猴和 PIGTA 的建立：艾滋病基因组

• 批准号: 8173373
• 负责人: Michael K Axthelm
• 金额: $ 13.34万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173373
• 关键词: AIDS Vaccines; AIDS-Related Opportunistic Infections; Animal Model; Breeding; Computer Retrieval of Information on Scientific Projects Database; Development; Disease; Environment; Funding; Future; Genetic; Genome; Grant; Housing; Human Virus; Immunocompromised Host; Institution; Lentivirus Infections; Macaca; Macaca mulatta; Pathogenesis; Research; Research Personnel; Resources; Source; Specific Pathogen Frees; United States National Institutes of Health; Viral; germ free condition; meetings; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (Provided by applicant): Opportunistic human viruses and their simian counterparts are similar in their genetic makeup and induce a similar spectrum of diseases in their immunosuppressed hosts. Experimental lentivirus infections in rhesus macaques are wildly recognized as the most import animal model for AIDS-related research and there is an urgent need to expand breeding programs to meet future AIDS vaccine and pathogenesis research program needs. Development of an Indian rhesus macaque breeding colony free of opportunistic viral agents is proposed to enhance the usefulness of this unique resource for studies focused on AIDS-related opportunistic infections. Housing space is proposed to provide a protected environment for this unique Expanded Specific Pathogen Free (ESPF) macaque resource and to facilitate enhanced macaque breeding efforts.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 描述（由申请人提供）：机会性人类病毒与其对应的猿猴病毒在基因组成上相似，并在其免疫抑制宿主中诱发相似的疾病谱。 恒河猴的实验性慢病毒感染被广泛认为是艾滋病相关研究最重要的动物模型，迫切需要扩大育种计划以满足未来艾滋病疫苗和发病机制研究计划的需求。 建议开发一个不含机会性病毒因子的印度恒河猴繁殖群，以增强这一独特资源在艾滋病相关机会性感染研究中的实用性。 住房空间旨在为这种独特的扩展无特定病原体（ESPF）猕猴资源提供受保护的环境，并促进加强猕猴繁殖工作。