Expanded SPF Rhesus Macaque Breeding Colony for AIDS Research

扩大 SPF 恒河猴繁殖群以进行艾滋病研究

• 批准号: 9536982
• 负责人: Michael K Axthelm
• 金额: $ 37.18万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9536982
• 关键词: Acquired Immunodeficiency Syndrome; Adult; Animal Model; Animals; Breeding; Communicable Diseases; Development; Disease; Female; Funding; Genetic; Genotype; HIV Infections; Health Sciences; Homologous Gene; Human; Immune response; Immunity; Immunological Models; Immunology; Infectious Diseases Research; Macaca; Macaca mulatta; Major Histocompatibility Complex; Microbial Genetics; Modeling; Opportunistic Infections; Oregon; Pathogenesis; Primates; Production; Request for Applications; Research; Resistance; Resources; SIV; Target Populations; Universities; Vaccine Research; Viral; Viral Vaccines; Virus; Zoonoses; base; design; enzootic; germ free condition; improved; offspring; pre-clinical; simian human immunodeficiency virus; vaccine development; vector vaccine

OVERALL PROJECT SUMMARY “Expanded SPF Rhesus Macaque Breeding Colony for AIDS Research” The Indian rhesus macaque (Macaca mulatta) develops a disease that closely mimics human acquired immunodeficiency syndrome (AIDS) when infected by simian immunodeficiency virus (SIV) or chimeric simian- human immunodeficiency viruses (SHIV), and represents the best animal model for HIV infection. Preclinical vaccine development is heavily dependent on the SIV and SHIV rhesus macaque models. The value and utility of the model are markedly enhanced by improving the level of microbial and genetic characterization. Macaques free of ubiquitous viruses that are homologues of human viruses responsible for opportunistic infections are essential for a growing number of AIDS-related opportunistic infection models and for viral vaccine vector development based on these agents. The utility of macaque models for immunological research has been hindered by the unprecedented complexity of their major histocompatibility complexes. Comprehensive MHC genotyping has the potential to revolutionize the use of macaques in infectious disease research and to guide functional immunology studies. MHC-restricted cellular immune responses are key in protective immunity and resistance to infectious diseases. The comprehensive objective of this application is to increase the capacity of the ONPRC AIDS Research Expanded SPF Breeding Colony to provide genetically characterized Indian-origin rhesus macaques free of a broad number of enzootic and zoonotic agents to enhance the usefulness of the resource for cutting edge opportunistic agent and vaccine research.

总体项目摘要 “扩大的SPF恒河猕猴育种菌落用于艾滋病研究” 印度恒河猕猴（Macaca Mulatta）开发了一种紧密模仿人类的疾病 免疫缺陷综合征（AIDS）被猿猴免疫缺陷病毒（SIV）或嵌合替代物感染时 人类免疫缺陷病毒（SHIV），代表了HIV感染的最佳动物模型。临床前 疫苗开发在很大程度上取决于SIV和SHIV恒河猴模型。价值和效用 通过提高微生物和遗传表征水平，可以显着增强该模型的模型。 没有无处不在的病毒的猕猴，这些病毒是人类病毒的同源物 感染对于越来越多的与艾滋病相关的机会感染模型和病毒至关重要 疫苗载体基于这些药物的开发。猕猴模型用于免疫学研究 其主要的组织相容性复合物的前所未有的复杂性阻碍了。 全面的MHC基因分型有可能改变猕猴在传染病中的使用 研究并指导功能免疫学研究。 MHC限制的细胞免疫调查是关键 保护性免疫学和对传染病的抵抗。 该应用程序的全面目标是提高ONPRC AIDS研究的能力 扩大的SPF育种菌落提供了普遍的特征性印度 - 原始恒河猕猴 广泛的enzootic和人畜共患剂，以增强资源对最前沿的实用性 机会主义和疫苗研究。