Phase 2 Enhancement of Outdoor Group Housing for U42 SPF 9 Rhesus Macaques

U42 SPF 9 恒河猴户外群舍第二期强化工程

• 批准号: 10360780
• 负责人: Michael K Axthelm
• 金额: $ 50万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10360780
• 关键词: AIDS vaccine development; AIDS-Related Opportunistic Infections; Acquired Immunodeficiency Syndrome; Address; Adult; Adult Children; Animal Husbandry; Animal Welfare; Animals; Area; Breeding; Clinical; Development; Environmental Protection; Female; Floor; Funding; Genetic; Goals; Health Sciences; Housing; Individual; Infant; Infrastructure; Lymphocryptovirus; Macaca; Macaca mulatta; Modification; Oregon; Phase; Population; Primates; Procedures; Production; Request for Applications; Research; Shelter facility; Social Welfare; Solid; Source; Structure; Universities; Viral; Water; Weather; animal breeding; animal care; design; flexibility; improved; male; man; mature animal; offspring; prevent; recruit; seroconversion; social; social group; square foot; symposium; transmission process; vector vaccine

PROJECT SUMMARY The Oregon National Primate Research Center (ONPRC) Expanded SPF (ESPF) Rhesus Macaque Breeding Colony is a highly specialized breeding colony that provides unique and essential macaques with an expanded SPF definition for AIDS research. This colony is critical for AIDS-related opportunistic infection research and vaccine vector development using opportunistic viral agents as vaccine vectors. In order to provide a sufficient number of appropriate animals, the breeding colony must produce 30 surplus animals annually. Concurrently, it is necessary to isolate lymphocryptovirus (LCV) free animals and re-derive LCV-free offspring from LCV seroconverted females in the colony and recruit additional LCV-free infants from Center's convention SPF colony. A critical shortage of appropriate ESPF social housing severely constrain both our efforts to increase the size of the breeding colony to meet project demand and our endeavors to eliminate LCV from the colony. The application proposes to complete modifications of the existing southwest outdoor sheltered housing structure providing an additional four 500 sq. ft. social housing units. The proposed modifications would expand the total number of outdoor ESPF breeding animals housed in social groups permitting increased production, facilitate genetic management by providing smaller housing units that are more appropriate for housing 7-10 females and a male and offspring, provide sufficient separation between individual housing units to prevent transmission of agents between groups, and improve animal welfare through social housing.

项目摘要 俄勒冈州国家灵长类动物研究中心（ONPRC）扩大了SPF（ESPF）恒河猕猴育种 殖民地是一个高度专业化的繁殖殖民 SPF定义艾滋病研究。这个殖民地对于与艾滋病相关的机会感染研究至关重要 使用机会性病毒剂作为疫苗载体的疫苗载体开发。为了提供足够的 适当的动物数量，繁殖菌落必须每年产生30个盈余动物。同时，它 分离淋巴结病毒（LCV）的无动物和从LCV中重新启发LCV的后代是必要的 殖民地中的血清转化女性，并从中心大会SPF招募其他无LCV婴儿 殖民地。适当的ESPF社会住房的严重短缺严重限制了我们增加的努力 满足项目需求的繁殖殖民地的规模以及我们从殖民地消除LCV的努力。 该申请建议完成现有西南户外庇护所住房的修改 结构提供了另外四个500平方英尺的社会住房单位。拟议的修改将 扩大社会群体中容纳的室外ESPF繁殖动物的总数，允许增加 生产，通过提供更适合的较小的住房单元来促进遗传管理 住房7-10位女性和一个男性和后代，在单个住房单位之间提供足够的分离 防止群体之间的代理商传播，并通过社会住房改善动物福利。