Novel Caging and Equipment to Enhance Social Interaction and Animal Wellbeing in U42 SPF9 Rhesus Macaques.

新型笼具和设备可增强 U42 SPF9 恒河猴的社交互动和动物福祉。

• 批准号: 10404873
• 负责人: Michael K Axthelm
• 金额: $ 49.98万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10404873
• 关键词: AIDS vaccine development; AIDS-Related Opportunistic Infections; Acquired Immunodeficiency Syndrome; Animal Housing; Animal Welfare; Animals; Area; Attention; Award; Breeding; Clinic; Custom; Development; Devices; Equipment; Female; Funding; Goals; Health; Health Sciences; Height; Housing; Infant; Infrastructure; Lymphocryptovirus; Macaca; Macaca mulatta; Oregon; Parents; Personal Satisfaction; Phase; Population; Primates; Problem behavior; Procedures; Production; Productivity; Request for Applications; Research; Resources; Shelter facility; Social Interaction; Social support; Socialization; Structure; Support Groups; System; Universities; Vaccine Research; Viral; Zoonoses; animal breeding; design; enzootic; improved; innovation; novel; offspring; prevent; recruit; research and development; risk minimization; social; square foot; transmission process; vector vaccine; welfare

PROJECT SUMMARY The Oregon National Primate Research Center (ONPRC) Expanded SPF (ESPF) Rhesus Macaque Breeding Colony is a highly specialized breeding colony that provides unique and essential macaques with an expanded SPF definition for AIDS research. This colony is critical for AIDS-related opportunistic infection research and vaccine vector development using opportunistic viral agents as vaccine vectors. In order to provide a sufficient number of appropriate animals, the breeding colony must produce 30 surplus animals annually. Concurrently, it is necessary to isolate lymphocryptovirus (LCV) free animals and re-derive LCV-free offspring from LCV seroconverted females in the colony and recruit additional LCV-free infants from Center's conventional SPF colony. A critical shortage of appropriate ESPF social housing severely constrain both our efforts to increase the size of the breeding colony to meet project demand and our endeavors to eliminate LCV from the colony. The application proposes to purchase novel caging and a tunnel to increase the colonies infrastructure for housing multiple cage-housed animals in the ESPF barrier housing facility. Enhancing social housing opportunities will benefit animals with existing behavioral problems, provide better developmental trajectories for infants recruited to the colony, and promote positive animal welfare and health, all while providing an avenue for ESPF population expansion to keep pace with demand. The application also proposes to purchase a storage shed for storing enrichment devices and animals transfer boxes. These items are dedicated for the exclusive support of ESPF macaques to minimize the risk of inadvertently compromising the animals ESPF status.

项目摘要 俄勒冈州国家灵长类动物研究中心（ONPRC）扩大了SPF（ESPF）恒河猕猴育种 殖民地是一个高度专业化的繁殖殖民 SPF定义艾滋病研究。这个殖民地对于与艾滋病相关的机会感染研究至关重要 使用机会性病毒剂作为疫苗载体的疫苗载体开发。为了提供足够的 适当的动物数量，繁殖菌落必须每年产生30个盈余动物。同时，它 分离淋巴结病毒（LCV）的无动物和从LCV中重新启发LCV的后代是必要的 菌落中的血清转化女性，并从中心的常规SPF招募其他无LCV婴儿 殖民地。适当的ESPF社会住房的严重短缺严重限制了我们增加的努力 满足项目需求的繁殖殖民地的规模以及我们从殖民地消除LCV的努力。 该申请建议购买新颖的笼子和隧道，以增加殖民地基础设施 在ESPF屏障住房设施中，在ESPF屏障设施中居住多个笼子。增强社会住房 机会将使现有行为问题的动物受益，提供更好的发展轨迹 对于招募到殖民地的婴儿，并促进积极的动物福利和健康，同时提供 ESPF人口扩展的途径可以跟上需求的步伐。该申请还建议购买 用于存储富集设备和动物的储物​​棚传输盒子。这些项目专门用于 ESPF猕猴的独家支持，以最大程度地减少无意中损害动物ESPF的风险 地位。