ICOS IN ATOPY

过敏症中的ICOS

• 批准号: 7604760
• 负责人: Anne I. Sperling
• 金额: $ 0.25万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604760
• 关键词: Adult; Age; Asthma; Blood; Breathing; Cells; Chemicals; Code; Computer Retrieval of Information on Scientific Projects Database; Condition; DNA; Disease; Family; Funding; Generations; Genes; Genetic; Grant; Hypersensitivity; Individual; Inflammation; Inflammatory; Institution; Lung; Names; Predisposition; Purpose; Research; Research Personnel; Resources; Source; Surface; T-Lymphocyte; Tube; United States National Institutes of Health; Work; atopy; interest; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to determine what influences allergy and asthma, a breathing disorder caused by inflammation in the breathing tubes of the lungs. This study is being done because we are interested in the genetics of allergy and asthma how asthma and allergy may be passed down in families through generations. Asthma and allergy are inflammatory diseases, and we are interested in how certain chemicals that regulate this inflammation are genetically controlled. One such chemical is named "ICOS" that is made on the surface of a cell in your blood, called "T lymphocytes" or simply "T cells"-. ICOS helps to control how these T cells respond to inflammation. We have found there are genetic differences in the on/off switch for the ICOS gene (a piece of DNA that has the code to make ICOS) in certain individuals and the genetic differences are associated with the predisposition to allergy. The major hypothesis is that people have genetic differences in the ICOS gene and these differences influence the chemicals their T cells make. As a result they are predisposed to asthma and allergy. We will be studying adults, ages 18 to 54, with allergy and asthma compared to people without either condition. The major questions that are being asked in this research study are 1) how do genetic differences in the on/off switch for ICOS change how much of this chemical is made in T cells, and 2) do these genetic differences change the way that the T cells work in people with allergy and asthma?

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的目的是确定什么影响过敏和哮喘，这是肺呼吸管中的炎症引起的呼吸障碍。这项研究之所以完成，是因为我们对过敏和哮喘的遗传学感兴趣，如何通过几代人在家庭中传播哮喘和过敏。哮喘和过敏是炎症性疾病，我们对某些调节这种炎症的化学物质如何受到遗传控制感兴趣。一种这样的化学物质被称为“ ICO”，它是在您的血液中细胞表面制成的，称为“ T淋巴细胞”或简单的“ T细胞” - 。 ICO有助于控制这些T细胞对炎症的反应。我们发现，ICOS基因的ON/OFF开关中存在遗传差异（具有某些个体具有ICOS代码的DNA）的遗传差异，遗传差异与过敏的倾向有关。主要的假设是人们在ICOS基因上具有遗传差异，这些差异会影响其T细胞所产生的化学物质。 结果，它们倾向于哮喘和过敏。 与没有任何条件的人相比，我们将研究18至54岁的成年人，过敏和哮喘。这项研究中提出的主要问题是1）ICO的ON/OFF开关中的遗传差异如何改变T细胞中这种化学物质的数量，而2）这些遗传差异是否会改变T细胞在过敏和哮喘患者中起作用的方式？