Factors Influencing Pediatric Asthma into Adulthood (FIPA2)

影响成年期小儿哮喘的因素 (FIPA2)

• 批准号: 10778115
• 负责人: LYLE G BEST
• 金额: $ 55.17万
• 依托单位: MISSOURI BREAKS RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-25 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10778115
• 关键词: 2019-nCoV; Adult; Affect; Age; American Indians; Area; Asthma; Biological; Biological Markers; Bronchiolitis; COVID-19 pandemic; Case/Control Studies; Cheyenne; Child; Childhood Asthma; Cities; Clinical; Clinical Trials; Communities; Complex; Data; Dedications; Development; Disease; Disparity; Education; Emergency department visit; Enrollment; Environmental Risk Factor; Ethnic Population; Frequencies; Funding; Gender; Goals; Health Policy; High Prevalence; Hospitalization; Household; IgE; Immune; Immune System Diseases; Immune response; Immune system; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; Immunologic Factors; Immunologics; Immunosuppression; Indian reservation; Individual; Industry; Infant; Inflammation; Influenza; Influenza A virus; Influenza B Virus; Intervention; Interview; Knowledge; Life; Link; Lower Respiratory Tract Infection; Measurement; Measures; Missouri; Modification; National Institute on Minority Health and Health Disparities; Not Hispanic or Latino; Outcome; Parents; Participant; Pharmaceutical Preparations; Policies; Population; Predisposition; Prevalence; Prevention strategy; Preventive measure; Process; Questionnaires; Randomized; Recontacts; Research; Reservations; Respiratory Signs and Symptoms; Respiratory Syncytial Virus Infections; Respiratory syncytial virus; Rhinovirus; Risk; Role; Rural; Seasons; Serology; Serum; Severities; Sioux Indians; South Dakota; Stress; Structure; Support System; Surveys; Symptoms; Testing; Teton Sioux Indian; Tobacco smoke; Tribes; Upper Respiratory Infections; Viral; Viral Respiratory Tract Infection; Virus Diseases; Work; adverse childhood events; asthma prevention; asthmatic; atopy; behavior influence; cytokine; design; experience; family support; follow-up; health disparity; infection burden; member; minority communities; neglect; novel strategies; offspring; pathogen; process evaluation; racial population; recruit; referral services; respiratory; respiratory health; response; social; social factors; social influence; social stress; stressor; tribal community; tribal health; tribal member; urban setting; volunteer

Title: FIPA2 M-PI: Best/Erdei/Torgerson Project Summary Pediatric asthma in American Indian (AI) communities of the Northern Plains Region presents a serious health disparity. While many previous works carried out in minority communities – but not in AI children- looked at individual level of influences on pediatric asthma and made parents responsible for asthma control, our study will bring together a more comprehensive and realistic framework. Our novel approach will move the study from the collected data toward Tribal health policy change. The FIPA2 study is designed to leverage the previously NIMHD-funded Factors Influencing Pediatric Asthma study (U54MD008164) which successfully enrolled 324 Cheyenne River Sioux Tribal (CRST) children (age 6-17 years) in 2013-2017. That study also had a randomized educational clinical trial component (NCT 03302962) and we documented results of that work. In the FIPA2 study, we will examine the complex interplay between social, environmental and immunological response to viral respiratory infections an gap in knowledge that remains largely unknown. In this continued AI community-focused pediatric asthma study, we will test the hypothesis that AI children with asthma have alterations in immunological response to several viral respiratory infections as compared to those without asthma. We will also investigate whether social and environmental factors (SEF) significantly contribute to this disparity through stressed-induced modification of immune state. We will explore the role of viral respiratory infections (RSV, rhinovirus C, and influenza A and B) and SEF on asthma severity, including frequency of exacerbations, ER visits/hospitalizations, and use of asthma medications. Aim 1 will identify social and environmental factors (SEF) that contribute to asthma susceptibility, severity and long-term respiratory health. Participants will be enrolled at our Missouri Breaks Industries Research Inc. main office by working with Reservation communities. To achieve enrollment goals, we will also enroll in Rapid City, SD, an urban setting where AIs also located (12.4% of the city’s population). In Aim 2, we will examine the role of SEF on immunological and clinical response to viral respiratory infections (VRIs) in AI children with and without asthma. We will test our hypothesis that interactions with detailed survey measures of SEF with immunological and clinical outcomes of VRIs, including seasonality of viral responses in participants with and without asthma are the strongest and most significant predictors in our AI participants. Aim 3 will bring a comprehensive and vivid community input to this study and will benefit from our local community advisory board (CAB) that supports the study. We will rely on our own, experienced CBPR-based and bidirectional process evaluation. We will create a feasible and community-driven asthma prevention framework that will be effective and can be applied in other AI communities as well.

标题：FIPA2 M-PI：最佳/Erdei/Torgerson 项目摘要 北平原地区美洲印第安人（AI）社区的儿科哮喘是严重的 健康差异。虽然许多以前在少数民族社区进行的工作 - 但在AI儿童中没有进行 在个人对小儿哮喘的影响方面，父母对哮喘的控制负责 研究将汇集一个更全面，更现实的框架。我们的新方法将移动 从收集的数据到部落卫生政策变化的研究。 FIPA2研究旨在利用 以前由NIMHD资助的因素影响小儿哮喘研究（U54MD008164） 2013 - 2017年招募了324个Cheyenne River Sioux Tribal（CRST）儿童（6-17岁）。该研究也有 随机教育临床试验部分（NCT 03302962），我们记录了这项工作的结果。在 FIPA2研究，我们将研究社会，环境和免疫学之间的复杂相互作用 对病毒呼吸道感染的反应差距在很大程度上未知。在此继续AI中 以社区为重点的儿科哮喘研究，我们将检验以下假设 与没有 哮喘。我们还将调查社会和环境因素（SEF）是否对此有所贡献 通过压力引起的免疫状态的修饰差异。我们将探讨病毒呼吸道的作用 感染（RSV，Rhinovirus C和actractza A和b）和SEF在哮喘严重程度上，包括频率 恶化，急诊室就诊/住院以及使用哮喘药物。目标1将确定社会和 有助于哮喘易感性，严重程度和长期呼吸健康的环境因素（SEF）。 参与者将通过与我们的密苏里州Breaks Industries Research Inc.的主办公室一起入学 保留社区。为了实现入学目标，我们还将参加城市环境的Rapid City，SD AIS也位于城市人口的12.4％。在AIM 2中，我们将研究SEF的作用 AI儿童有和没有的AI儿童对病毒呼吸道感染（VRI）的免疫学和临床反应 哮喘。我们将测试我们的假设，即与免疫学的SEF的详细调查指标相互作用 VRI的临床结果，包括患有和没有哮喘的参与者的病毒反应季节性 是我们AI参与者中强大，最重要的预测因素。 AIM 3将带来全面的 生动的社区投入这项研究，将受益于我们当地的社区顾问委员会（CAB） 支持这项研究。我们将依靠自己的，经验丰富的基于CBPR的双向过程评估。 我们将创建一个可行且由社区驱动的预防哮喘框架，这将是有效的，并且可以是 也应用于其他AI社区。