Institutional Career Development Core

机构职业发展核心

• 批准号: 10356822
• 负责人: PAUL R MARANTZ
• 金额: $ 53.94万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-22 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10356822
• 关键词: Award; Biomedical Research; Career Choice; Clinical; Clinical Research; Clinical Sciences; Competence; Complex; Deltastab; Development; Development Plans; Discipline; Doctor of Philosophy; Education; Extramural Activities; Faculty; Foundations; Funding; Goals; Grant; Health; Health Care Research; Healthcare Systems; Hybrids; Incentives; Individual; Institutes; Internet; K-Series Research Career Programs; Learning; Link; Master of Science; Medical Care Team; Mentored Clinical Scientist Development Program; Mentors; Methodology; NCI Scholars Program; National Center for Research Resources; National Research Service Awards; Process; Program Development; Publications; Publishing; Qualifying; Reproducibility; Research; Research Methodology; Research Personnel; Rewards; Scholarship; Science; Source; Stream; Study Section; TNFSF15 gene; Talents; Technology; Time; Training; Training Programs; Training and Education; Translational Research; United States Agency for Healthcare Research and Quality; Workforce Development; career; career development; competitive environment; crosslink; experience; faculty research; flexibility; innovation; instructor; multidisciplinary; novel; novel strategies; professor; programs; research and development; teacher; translational scientist

The Einstein-Montefiore Institute for Clinical and Translational Research (ICTR) has developed and supported a highly integrated core of education and career development programs in clinical and translational research. In this new application, we describe our KL2 program, along with a range of synergistic and complementary career development award (CDA) programs. Along with a menu of didactic offerings, led by our flagship educational program, the MSc-granting Clinical Research Training Program (CRTP), these programs comprise a robust set of options to support the development of early-stage investigators. Our career development programs seek to accomplish the overarching goal: to identify, educate, support, and mentor talented clinical and non-clinical faculty and staff toward their development as impactful and successful clinical/translational scientists through working toward the following aims: 1) to build upon a robust foundation in clinical and translational research educational programs by developing new innovative programmatic initiatives, including methodologically-focused ‘tracks’ within our CRTP and novel applications of distance- and hybrid-learning technologies; 2) to promote team science competencies in our learners, while incentivizing and rewarding team science contributions in our institutional setting; 3) to effectively link research and health improvement through novel approaches to education and career development within a learning healthcare system, harmonizing scholarship and implementation and providing sustainable career pathways for clinician-investigators in research/healthcare teams; 4) to promote and support diversity in the clinical/translational research workforce. Our CTSA-funded CDA (KL2) program is coordinated with institutional and other, non-overlapping, extramural support, providing both leveraging and flexibility to maximize the impact of our efforts. KL2 Scholars are selected through a competitive study-section-type review process from among junior faculty at the Instructor or Assistant Professor level with sufficient background and experience to demonstrate their potential for a career in clinical or translational research. Each Scholar has an individually-tailored career development plan that is overseen by the Program Director, Dr. Paul Marantz. A special requirement of the program is that each applicant identify two mentors with appropriate and complementary experience and expertise, who also cross a “translational divide”. This new application builds on a 15-year track record of multidisciplinary career development efforts at Einstein-Montefiore, beginning in 2002 with an NCRR-funded K12 program. There have been 37 awardees over that time period, excluding the current Scholars. All 37 K Awardees have published since they received the KL2 grant. 95% have at least one first authored publication and 84% have been a senior author on at least one publication. 24 of the 37 awardees have gone on to obtain additional funding, receiving 52 grants in all. The new and expanded approach presented in this application will provide opportunities to a broader range of Scholars who can succeed in an increasingly competitive environment.

爱因斯坦-蒙蒂菲奥里临床和转化研究所 (ICTR) 开发并支持 临床和转化研究方面高度集成的教育和职业发展计划核心。 在这个新应用程序中，我们描述了我们的 KL2 计划，以及一系列协同和互补的计划 职业发展奖 (CDA) 计划以及由我们的旗舰产品主导的一系列教学产品。 教育计划，授予理学硕士学位的临床研究培训计划（CRTP），由这些计划组成 一套强大的选择来支持早期研究人员的职业发展。 计划力求实现总体目标：识别、教育、支持和指导有才华的临床 和非临床教职员工的发展成为有影响力和成功的临床/转化 科学家们通过努力实现以下目标：1）在临床和 通过开发新的创新计划举措来开展转化研究教育计划，包括 我们的 CRTP 中注重方法论的“轨道”以及远程和混合学习的新颖应用 技术；2）提高学习者的团队科学能力，同时激励和奖励团队 我们的机构环境中的科学贡献；3）通过以下方式有效地将研究与健康改善联系起来： 在学习医疗保健系统内进行教育和职业发展的新颖方法，协调 奖学金和实施，并为临床医生研究人员提供可持续的职业道路 研究/医疗保健团队；4) 促进和支持临床/转化研究队伍的多样性。 我们由 CTSA 资助的 CDA (KL2) 计划与机构和其他不重叠的校外项目进行协调 支持，提供杠杆和灵活性，以最大限度地发挥我们的努力的影响。 通过竞争性研究部分类型的审查过程从讲师的初级教师中选出，或 助理教授级别，具有足够的背景和经验来展示其职业潜力 在临床或转化研究领域，每位学者都有一个量身定制的职业发展计划。 由项目总监 Paul Marantz 博士监督 该项目的一个特殊要求是： 申请人确定两名具有适当且互补的经验和专业知识的导师，他们也跨领域 “翻译鸿沟”这一新应用建立在 15 年多学科职业记录的基础上。 Einstein-Montefiore 的开发工作始于 2002 年，由 NCRR 资助的 K12 项目。 在此期间共有 37 名获奖者（不包括当前的所有 37 K 获奖者）已发表文章。 自从获得 KL2 资助以来，95% 的人至少拥有一篇第一作者的出版物，84% 的人是第一作者。 37 名获奖者中，至少有 24 名出版物的资深作者获得了额外资助， 本申请中提出的新的和扩展的方法将总共获得 52 项资助。 为更广泛的学者提供机会，让他们能够在竞争日益激烈的环境中取得成功。

项目成果

Urine Proteomics Link Complement Activation with Interstitial Fibrosis/Tubular Atrophy in Lupus Nephritis Patients.

尿液蛋白质组学将补体激活与狼疮性肾炎患者的间质纤维化/肾小管萎缩联系起来。

• 发表时间: 2023-12
• 影响因子: 5
• 作者: Wang, Shudan;Broder, Anna;Shao, Daming;Kesarwani, Vartika;Boderman, Brianna;Aguilan, Jennifer;Sidoli, Simone;Suzuki, Masako;Greally, John M;Saenger, Yvonne M;Rovin, Brad H;Michelle Kahlenberg, J
• 通讯作者: Michelle Kahlenberg, J

Longitudinal Associations of Social Support and Gait Speed Decline in Aging.

社会支持和步态速度随着衰老而下降的纵向关联。

• 发表时间: 2024-03-01
• 作者: Pollak, Chava;Verghese, Joe;Blumen, Helena M
• 通讯作者: Blumen, Helena M

Factors Influencing the Referral of Patients with Prediabetes to a Diabetes Prevention Program in the Bronx, New York.

影响纽约布朗克斯区糖尿病前期患者转诊至糖尿病预防计划的因素。

• 发表时间: 2023-09-21
• 影响因子: 5.5
• 作者: Stephenson-Hunter C;Pacheco G;Kim RS;Gao Q;Hosgood HD;Chambers EC
• 通讯作者: Chambers EC

Ketone Bodies Rescue Mitochondrial Dysfunction Via Epigenetic Remodeling.

酮体通过表观遗传重塑挽救线粒体功能障碍。

• 发表时间: 2023-09
• 作者: Gambardella, Jessica;Jankauskas, Stanislovas S;Kansakar, Urna;Varzideh, Fahimeh;Avvisato, Roberta;Prevete, Nella;Sidoli, Simone;Mone, Pasquale;Wang, Xujun;Lombardi, Angela;Santulli, Gaetano
• 通讯作者: Santulli, Gaetano

Factors Associated with Worsening Interstitial Fibrosis/Tubular Atrophy in Lupus Nephritis Patients Undergoing Repeat Kidney Biopsy.

与接受重复肾活检的狼疮性肾炎患者间质纤维化/肾小管萎缩恶化相关的因素。

• 发表时间: 2024-01-23
• 作者: Shao, Daming;Jimenez, Alejandra Londoño;Guerrero, Maria Salgado;Wang, Shudan;Broder, Anna
• 通讯作者: Broder, Anna