NRSA Training Core

NRSA 培训核心

• 批准号: 10357765
• 负责人: PAUL R MARANTZ
• 金额: $ 21.12万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-22 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10357765
• 关键词: Award; Biological Sciences; Biomedical Research; Clinical; Clinical Research; Clinical Sciences; Collaborations; Complement; Complex; Deltastab; Discipline; Doctor of Philosophy; Education; Educational Curriculum; Extramural Activities; Funding; Goals; Grant; Growth; Institutes; Internet; Investigation; Knowledge; Laboratories; Link; Medical; Mentors; NCI Scholars Program; National Institute of General Medical Sciences; National Research Service Awards; Population; Population Sciences; Postdoctoral Fellow; Program Development; Reporting; Reproducibility; Research; Research Methodology; Research Personnel; Science; Scientist; Source; Stream; Students; TNFSF15 gene; Talents; Techniques; Time; Training; Training Programs; Training and Education; Translational Research; United States Agency for Healthcare Research and Quality; United States National Institutes of Health; base; career development; clinical investigation; crosslink; education research; faculty research; improved; innovation; novel; novel strategies; pre-doctoral; programs; recruit; skills; teacher mentor; translational scientist

The Einstein-Montefiore Institute for Clinical and Translational Research (ICTR) has developed and supported a highly integrated core of education and career development programs in clinical and translational (C/T) research, accelerated by the funding of our first CTSA grant in 2008. Among our interlinked and coordinated education and career development programs, our innovative PhD in Clinical Investigation (PCI) has developed into a growing and increasingly effective training program; this new application will provide further growth and enhancement. The Specific Aims in our new NRSA Training Core application are: 1) to identify, educate, support, and mentor talented PhD and MD-PhD candidates to become impactful and successful clinical/translational scientists; 2) to encourage and facilitate translational research collaborations through interdisciplinary co-mentoring of trainees and novel approaches to supporting team science; 3) to promote a research culture that approaches all research responsibly, conducts all research rigorously, and reports all research in a manner supporting its reproducibility; 4) to rigorously evaluate and continuously improve our pre- and post-doctoral educational programs. Our students are funded not only by our NRSA training grant and institutional funds, but also (as appropriate) through other extramural sources, including a novel training grant from the Burroughs Wellcome Fund and the Medical Scientist Training Program (MSTP) grant from NIH/NIGMS. We seek to provide our graduates with the knowledge and skills to serve them well in a broad range of settings. The expansion our PhD program, eCLIPSE (education Connecting Laboratory Investigation and Population Science at Einstein), has grown out of our innovative PhD in Clinical Investigation, which began with our first CTSA grant. The overall goal of eCLIPSE is to produce scientists who are cross trained and facile with the techniques and research methods employed by both laboratory-based basic scientists and population-oriented researchers. Our core curriculum includes carefully selected courses from both our biomedical sciences PhD program and our MSc program in Clinical Research, complemented by program-specific seminars and oversight. A cornerstone of eCLIPSE is thoughtful and conscientious co-mentoring from established investigators, with one mentor from the laboratory sciences and one from the population sciences. A new mentor training program, emphasizing co-mentoring, is planned for the next project period, as is a novel recruitment effort to identify candidates from relevant disciplines beyond the biological sciences. Our initial PCI enrollee received her PhD in 2012; since then, 4 additional PhDs were conferred in 2016 (3 PhD, 1 MD/PhD), and there are currently 9 predoctoral students (6 PhD, 3 MD/PhD) working toward their degrees.

爱因斯坦-蒙蒂菲奥里临床和转化研究所 (ICTR) 开发并支持 临床和转化 (C/T) 领域教育和职业发展计划的高度集成核心 2008 年我们第一笔 CTSA 赠款的资助加速了研究的发展。 教育和职业发展计划，我们的临床研究 (PCI) 创新博士学位 发展成为一个不断发展且日益有效的培训计划；这个新的应用程序将提供进一步 成长和增强。我们新的 NRSA 培训核心应用程序的具体目标是：1) 识别、 教育、支持和指导有才华的博士和医学博士候选人，使其变得有影响力和成功 临床/转化科学家； 2) 鼓励和促进转化研究合作 受训者的跨学科共同指导和支持团队科学的新方法； 3）促进 负责任地进行所有研究、严格进行所有研究并报告所有研究的研究文化 以支持其可重复性的方式进行研究； 4) 严格评估并持续改进我们的前期和后期工作 博士后教育计划。我们的学生不仅获得 NRSA 培训补助金的资助， 机构资金，但也（酌情）通过其他外部来源，包括新的培训补助金 来自 Burroughs Wellcome 基金和医学科学家培训计划 (MSTP) 的资助 NIH/NIGMS。我们致力于为毕业生提供知识和技能，以便在广泛的领域为他们提供良好的服务 设置范围。我们的博士项目 eCLIPSE（教育连接实验室调查）的扩展 和爱因斯坦的人口科学），是从我们的临床研究创新博士学位发展而来的，该博士学位始于 获得我们的第一笔 CTSA 资助。 eCLIPSE 的总体目标是培养经过交叉培训且易于掌握的科学家 结合基于实验室的基础科学家和面向人群的技术和研究方法 研究人员。我们的核心课程包括从我们的生物医学领域精心挑选的课程 科学博士课程和临床研究理学硕士课程，并辅以特定课程 研讨会和监督。 eCLIPSE 的基石是深思熟虑、认真负责的共同指导 设立了研究人员，其中一名导师来自实验室科学，一名导师来自人口科学。 计划在下一个项目期间实施新的导师培训计划，强调共同指导，这也是一项新颖的计划 招聘工作，以确定生物科学以外相关学科的候选人。我们最初的 PCI 注册者于 2012 年获得博士学位；此后，2016 年又授予了 4 名博士学位（3 名博士，1 名医学博士/博士）， 目前有 9 名博士前学生（6 名博士，3 名医学博士/博士）正在攻读学位。

项目成果

Implementation of a Standardized Approach to Improve the Pediatric Discharge Medication Process.

实施标准化方法来改进儿科出院用药流程。

• 发表时间: 2021
• 影响因子: 8
• 作者: Philips, Kaitlyn;Zhou, Roy;Lee, Diana S;Marrese, Christine;Nazif, Joanne;Browne, Constance;Sinnett, Mark;Tuckman, Steven;Modi, Anjali;Rinke, Michael L
• 通讯作者: Rinke, Michael L

Implicit Bias Recognition and Management: Tailored Instruction for Faculty.

隐性偏见的识别和管理：为教师量身定制的指导。

• 发表时间: 2021-10
• 影响因子: 3.3
• 作者: Rodriguez, Natalia;Kintzer, Emily;List, Julie;Lypson, Monica;Grochowalski, Joseph H;Marantz, Paul R;Gonzalez, Cristina M
• 通讯作者: Gonzalez, Cristina M

SKP2 knockout in Rb1/p53 deficient mouse models of osteosarcoma induces immune infiltration and drives a transcriptional program with a favorable prognosis.

Rb1/p53 缺陷小鼠骨肉瘤模型中的 SKP2 敲除可诱导免疫浸润并驱动转录程序，从而具有良好的预后。

• DOI: 10.1158/1535-7163.mct-23-0173
• 发表时间: 2023-10-24
• 期刊: Molecular cancer therapeutics
• 影响因子: 5.7
• 作者: A. Ferrena;Jichuan Wang;Ranxin Zhang;Burcu Karadal;Waleed Al;Swapnil Singh;Hasibagan Borjihan;Edward L Schwartz;Hongling Zhao;Maja H Oktay;Rui Yang;David S Geller;Bang H Hoang;D. Zheng
• 通讯作者: D. Zheng

A counterpoint to "training the translational workforce: expanding beyond translational research to include translational science".

与“培训转化劳动力：从转化研究扩展到包括转化科学”相对应。

• 发表时间: 2020-04-06
• 作者: Marantz, Paul R;Keller, Marla J;Meagher, Emma A
• 通讯作者: Meagher, Emma A

Transcription factor MEF2D is required for the maintenance of MLL-rearranged acute myeloid leukemia.

MLL 重排急性髓性白血病的维持需要转录因子 MEF2D。

• 发表时间: 2021-11-23
• 影响因子: 7.5
• 作者: Zhao, Lianzhong;Zhang, Pengcheng;Galbo, Phillip M;Zhou, Xinyue;Aryal, Sajesan;Qiu, Shaowei;Zhang, Hao;Zhou, Yang;Li, Chunliang;Zheng, Deyou;Bhatia, Ravi;Lu, Rui
• 通讯作者: Lu, Rui