Micro-and Nano-space Explorations of Health and Disease

健康与疾病的微纳空间探索

• 批准号: 7557887
• 负责人: Samuel Monroe DUBOISE
• 金额: $ 26.8万
• 依托单位: UNIVERSITY OF SOUTHERN MAINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-01 至 2013-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7557887
• 关键词: Archaea; Automobile Driving; Bacteria; Biochemistry; Biological; Biological Sciences; Biology; Biomass; Collaborations; Communicable Diseases; Complex; Development; Developmental Biology; Digital Libraries; Disease; Ecology; Ecosystem; Education and Outreach; Educational Curriculum; Electron Microscope; Electron Microscopy; Engineering; Evolution; Faculty; Food Chain; Foundations; General Population; Genetic; Health; Human; Immune; Immunology; Knowledge; Laboratories; Laws; Life; Maine; Medical; Microbe; Microbiology; Microscopy; Molecular; Molecular Biology; Nanotechnology; Organism; Participant; Phase; Physics; Process; Production; Publications; Reagent; Resources; Science; Scientist; Sensory; Space Explorations; Specialist; Students; Trees; Universities; Virus; Visual; Visual Perception; base; digital; microbial; middle school; nano; nanoscale; nutrition; outreach; programs; quantum; science education; skills; teacher; tomography; tool; transmission process; virology; web site

DESCRIPTION (provided by applicant): The unseen world, both living and non-living, at the micro-scale and the nano-scale has inordinate importance for health and disease and is only made visible in detail through the appropriate tools of microscopy. In this project University of Southern Maine (USM) faculty and staff with expertise in electron microscopy, microbiology, virology, and immunology team up with elementary and middle school education and outreach specialists and the staff of USM's Southworth Planetarium to reveal vast but usually invisible micro-space/nano-space worlds to grades 3-8 students and K-12 teachers and ultimately to bring these worlds to students across Maine and the nation. Starting with macroscopic and multi-sensory observations, the project staff (during Phase I) will enhance visual perception of program participants by more than five orders of magnitude using USM microscopy resources including a new Tecnai BioTwin fully digital transmission electron microscope (TEM) with advanced tomography capabilities in the USM Virology and TEM Laboratory which the PI directs. Phase I of the project (years 1 to 3) will emphasize collaboration of biomedical sciences faculty and staff, K-12 participants, and the staff of USM's Southworth Planetarium on curriculum materials and production of visual resources for far-reaching educational outreach. Phase II of the project will focus on dissemination of curricula and other products of the project while expanding outreach efforts throughout Maine and integrating the academic year programs for K-12 teachers into the academic offerings of the Department of Applied Medical Sciences.

描述（由申请人提供）：看不见的世界，无论是生物还是非生物，在微米尺度和纳米尺度上对于健康和疾病具有极其重要的意义，并且只有通过适当的显微镜工具才能详细可见。在这个项目中，拥有电子显微镜、微生物学、病毒学和免疫学专业知识的南缅因大学 (USM) 教职员工与中小学教育和外展专家以及南缅因大学索斯沃斯天文馆的工作人员合作，揭示了巨大但通常看不见的微观微观现象。 -向 3-8 年级学生和 K-12 教师提供太空/纳米太空世界，并最终将这些世界带给缅因州和全国的学生。从宏观和多感官观察开始，项目工作人员（第一阶段）将使用 USM 显微镜资源，包括具有先进技术的新型 Tecnai BioTwin 全数字透射电子显微镜 (TEM)，将项目参与者的视觉感知提高五个数量级以上。 PI 领导的 USM 病毒学和 TEM 实验室具有断层扫描能力。该项目的第一阶段（第一年至第三年）将强调生物医学科学教职员工、K-12 参与者以及 USM 索思沃斯天文馆工作人员在课程材料和视觉资源制作方面的合作，以实现深远的教育推广。该项目的第二阶段将侧重于传播该项目的课程和其他产品，同时扩大缅因州各地的外展工作，并将 K-12 教师的学年计划纳入应用医学科学系的学术课程中。