Micro-and Nano-space Explorations of Health and Disease

健康与疾病的微纳空间探索

• 批准号: 7902315
• 负责人: Samuel Monroe DUBOISE
• 金额: $ 19.93万
• 依托单位: UNIVERSITY OF SOUTHERN MAINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-31 至 2012-08-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7902315
• 关键词: Micro; Nano; space; Explorations; Health

DESCRIPTION (provided by applicant): The unseen world, both living and non-living, at the micro-scale and the nano-scale has inordinate importance for health and disease and is only made visible in detail through the appropriate tools of microscopy. In this project University of Southern Maine (USM) faculty and staff with expertise in electron microscopy, microbiology, virology, and immunology team up with elementary and middle school education and outreach specialists and the staff of USM's Southworth Planetarium to reveal vast but usually invisible micro-space/nano-space worlds to grades 3-8 students and K-12 teachers and ultimately to bring these worlds to students across Maine and the nation. Starting with macroscopic and multi-sensory observations, the project staff (during Phase I) will enhance visual perception of program participants by more than five orders of magnitude using USM microscopy resources including a new Tecnai BioTwin fully digital transmission electron microscope (TEM) with advanced tomography capabilities in the USM Virology and TEM Laboratory which the PI directs. Phase I of the project (years 1 to 3) will emphasize collaboration of biomedical sciences faculty and staff, K-12 participants, and the staff of USM's Southworth Planetarium on curriculum materials and production of visual resources for far-reaching educational outreach. Phase II of the project will focus on dissemination of curricula and other products of the project while expanding outreach efforts throughout Maine and integrating the academic year programs for K-12 teachers into the academic offerings of the Department of Applied Medical Sciences.

描述（由申请人提供）：在微观尺度和纳米规模上，看不见的世界和非生活世界对健康和疾病的重要性非常重要，只能通过适当的显微镜工具详细地看到。在该项目中，缅因州大学（USM）的教职员工在电子显微镜，微生物学，病毒学和免疫学方面具有专业知识，与小学和中学教育和外展专家以及USM Southworth Paranetarium的工作人员合作，揭示了广阔但通常是无形的微型微观。 - 为3 - 8年级学生和K-12老师的空间/纳米空间世界，最终将这些世界带给缅因州和国家的学生。从宏观和多感官观察开始，使用USM显微镜资源（包括新的Tecnai Biotwin完全数字传输电子显微镜（TEM）），项目人员（在第一阶段）将通过超过五个数量级来增强对程序参与者的视觉感知。 PI指示的USM病毒学和TEM实验室中的断层扫描功能。该项目的第一阶段（第1至3年）将强调生物医学科学教职员工，K-12参与者以及USM Southworth Paranetarium关于课程材料的工作人员的合作，并为深远的教育外展提供视觉资源。该项目的第二阶段将着重于将课程和项目的其他产品传播，同时扩大整个缅因州的外展工作，并将K-12教师的学年计划整合到应用医学科学系的学术产品中。